Yılmaz Kafalı, HelinDaşgın, HacerŞahin Çevik, DidenurSozan, Sara SinemOğuz, Kader K.Mutlu, MügeÖzkaya Parlakay, AslınurToulopoulou, Timothea2023-12-072023-12-072023-12Yılmaz Kafalı, H., Daşgın, H., Şahin Çevik, D., Sozan, S. S., Oğuz, K. K., Mutlu, M., Özkaya Parlakay, A. & Toulopoulou, T. (2023). The effect of SARS-CoV-2 virus on resting-state functional connectivity during adolescence: Investigating brain correlates of psychotic-like experiences and SARS-CoV-2 related inflammation response. Psychiatry Research - Neuroimaging, 336, 1-8. doi:10.1016/j.pscychresns.2023.1117460925-4927https://hdl.handle.net/11729/5805http://dx.doi.org/10.1016/j.pscychresns.2023.111746This work was supported by The Scientific and Technological Research Council of Turkey (TÜBİTAK) (Grant Number: 120K729 ) to TT.We first aimed to investigate resting-state functional connectivity (rs-FC) differences between adolescents exposed to SARS-CoV-2 and healthy controls. Secondly, the moderator effect of PLEs on group differences in rs-FC was examined. Thirdly, brain correlates of inflammation response during acute SARS-CoV-2 infection were investigated. Eighty-two participants aged between 14 and 24 years (SARS-CoV-2 (n = 35), controls (n = 47)) were examined using rs-fMRI. Seed-based rs-FC analysis was performed. The positive subscale of Community Assessment of Psychotic Experiences-42 (CAPE-Pos) was used to measure PLEs. The SARS-CoV-2 group had a lesser rs-FC within sensorimotor network (SMN), central executive network (CEN) and language network (LN), but an increased rs-FC within visual network (VN) compared to controls. No significant differences were detected between the groups regarding CAPE-Pos-score. However, including CAPE-Pos as a covariate, we found increased rs-FC within CEN and SN in SARS-CoV-2 compared to controls. Among the SARS-CoV-2 group, neutrophil/lymphocyte and thrombocyte*neutrophil/lymphocyte ratio was correlated with decreased/increased FC within DMN and SN, and increased FC within CEN. Our results showed rs-FC alterations within the SMN, CEN, LN, and VN among adolescents exposed to SARS-CoV-2. Moreover, changes in rs-FC associated with PLEs existed in these adolescents despite the absence of clinical changes. Furthermore, inflammation response was correlated with alterations in FC within the triple network system.eninfo:eu-repo/semantics/closedAccessAdolescentBrain networksCOVID-19Functional connectivityInflammation markersNeuroimagingPsychosis pronenessArticle33618Q3Q3WOS:001150025800001WOS:001150025800001PMID:37979347379793472-s2.0-8517797663510.1016/j.pscychresns.2023.111746Q1