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Boundary element method for EEG single-dipole localization: a study in patients with OCD
(Institute of Electrical and Electronics Engineers Inc., 2025-08-15) Abdullahi, Fatima I.; Demirer, Rüştü Murat
This study investigates EEG dipole localization in patients diagnosed with obsessive-compulsive disorder (OCD) using the Boundary Element Method (BEM) implemented via Brainstorm and OpenMEEG. EEG signals from 33 OCD patients were analyzed using a realistic, multi-layer head model consisting of scalp, skull, and brain tissues with respective conductivity values. Dipoles were accurately localized for each discrete time instant within the gamma frequency range (20-50 Hz) using a single dipole assumption per time point. EEG potentials measured from 19 standard electrodes were numerically computed by solving the forward EEG problem with the boundary element approach provided by OpenMEEG. Spectral clustering analysis identified distinct neural patterns corresponding to clinically recognized OCD subtypes, facilitating better diagnostic interpretations. Our results address previous methodological limitations by combining realistic head geometry modeling and precise temporal and spatial dipole estimation, offering promising directions for enhanced EEG-based diagnostic tools in psychiatry.