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  • Küçük Resim
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    Effects of childhood trauma and clinical features on determining quality of life in patients with bipolar I disorder
    (Elsevier Science BV, 2014-06-20) Erten, Evrim; Funda Uney, Aslı; Saatçioğlu, İbrahim Ömer; Özdemir, Armağan; Fıstıkçı, Nurhan; Çakmak, Duran
    Background: We explored how childhood trauma (CHT) affects the clinical expression of disorder and quality of life in patients with bipolar I (BP I) disorder.Methods: Euthymic patients (n=116) who subsequently received a diagnosis of BP-I disorder were consecutively included and were interviewed using the following sociodemographic and clinical data forms; Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HDRS), Childhood Abuse and Neglect Questionnaire (CANQ) and the 36 item Medical Outcome Study Short Form Health Survey (SF 36) The quality of life of BP-I patients with and without a history of CHT were examined.Results: The percentage of trauma was 61.2%. Patients who had CHT had higher frequencies of depressive episodes (t = -2.38, p=0.019), total episodes (t = -2.25, p=0.026), attempted suicide more often (chi(2)=18.12, p=0.003) and had lower scores on the pain subscale of Lhe SF 36 (z=-2.817, p=0.005). In patients with mixed or rapid-cycling episodes, SF-36 subscale scores except general health and pain were Found to be lower.Limitations: Our sample may fail to reflect the general BD population; the patients were included consecutively and consisted of a majority of female patients.Conclusions: CHT plays an important role in the clinical expression of BP-I disorder and having mixed/rapid-cycling episodes negatively affects both physical and mental components, as measured by the SF-36. While both males and females reported experiencing sexual abuse, female BP-I patients complained about pain more often. It is suggested that treatment of BP-1 patients with a history of CHT should differ from that provided for patients with no CHT history.
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    Executive functions and thyroid volumes in bipolar patients on lithium treatment
    (In House Publications, 2014-09-30) Fıstıkçı, Nurhan; Cantürk, Gülsüm; Saatçioğlu, İbrahim Ömer; Erten, Evrim; Keyvan, Ali; Turan, Nurten
    Aim: The purpose of this study was to investigate the relationship between executive functions and thyroid ultrasound parameters in remitted bipolar patients who were on lithium treatment. Methods: In the current study, 25 remitted patients with diagnoses of Bipolar I Disorder having blood lithium, and thyroid hormone levels within the normal range were consecutively enrolled. Healthy control group consisted of 25 euthyroid people matched as an age, sex and education level with the patients. Semi-structured sociodemographic and clinical form, the Structured Clinical Interview for DSM-IV Axis I Disorders, the Montreal Cognitive Assessment (MoCA), the Hamilton Depression Scale, Young Mania Rating Scale, thyroid ultrasonography and the Wisconsin Card Sorting Test (WCST) were applied to both groups. Within the patient group, correlation analysis was performed between WCST performance and thyroid volume. Results: In the present study, no significant difference was found between the bipolar and the healthy control groups regarding the executive functions as measured via WCST. In the bipolar patients, there were no statistically significant correlations among WCST scores and thyroid volumes. Conclusion: Thyroid volumes are not appeared to be associated with executive functions in euthymic bipolar patients.
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    Yatarak tedavi görmüş geriyatrik unipolar depresyon ve bipolar bozukluk hastaların klinik ve sosyodemografik özelliklerinin karşılaştırılması
    (Istanbul Universitesi, 2015-12) Cesur, Ender; Fıstıkçı, Nurhan; Dönmezler, Fadime Gizem; Çarpar, Elif; Erten, Evrim; Keyvan, Ali; Saatçioğlu, İbrahim Ömer
    Amaç: Bipolar bozukluk, toplumda %1 oranında görülen kronik bir hastalık olmakla beraber, yaşlılardaki yaygınlık oranı % 0.1 kadar düşüktür. Major depresyonun ise 70-85 yaşından sonra prevalans ve insidansı iki kat artmaktadır. Çalışmanın amacı, yatarak tedavi gören bipolar bozukluk(BB) ve unipolar depresyon(UD) tanılarıyla izlenen geriyatrik hastaların sosyodemografik ve klinik özelliklerinin araştırılmasıdır.Yöntem: Çalışmada Bakırköy Ruh ve Sinir Hastalıkları Hastanesi’nde yatmış olan, 65 yaş ve üzeri BB ve UD hastalarının sosyodemografik ve klinik özellikleri tıbbi kayıtları üzerinden karşılaştırılmıştır. Madde/ilaç, başka bir sağlık durumuna bağlı duygudurum bozukluğu tanısı olanlar ya da demans, deliryum tanısı olan hastalar çalışmaya dahil edilmemiştir. Bulgular: Tüm hastaların yaş ortalaması 69,3’tür. Çalışmaya dahil edilen 93 hastanın 51 tanesinde (%54,8) BB, 42 tanesinde(%45,2) UD tanısı bulunmaktadır. Hastalığın başlangıç yaşı BB için 41,33 iken UD için 59,21 bulunmuştur(p=0,000). UD hasta grubunun yatışındaki intihar fikri oranı %78,6 olup BB hasta grubununki %17,6’dır(p=0,000). UD grubundan 20(%47.6) kişi daha önce en az bir kere intihar girişiminde bulunmuşken bu sayı bipolar hasta grubunda 12(%23.5) olarak saptanmıştır(p=0,03). BB hastalarının ilaç uyumsuzluğu %51,0 iken UD hastalarında (%26,2) anlamlı derecede düşüktür (p=0,000). BB grubunun tedavisinde antipsikotikler (%100), depresyon hastalarına (%76,2) oranla daha sık kullanılmıştır(p=0,000). Sonuçlar: Yatarak tedavi görmüş unipolar ve bipolar geriyatrik hastalarda önemli klinik farklar saptanmıştır.