Computational model of the ventricular action potential in adult spontaneously hypertensive rats
Yükleniyor...
Dosyalar
Tarih
2003-09-01
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Introduction: Cardiac hypertrophy has substantial clinical significance because many hypertrophic cells have markedly prolonged repolarization behavior, which may lead to increased risk for cardiac arrhythmias. Spontaneously hypertensive rat (SHR) is one model of hypertension that is studied extensively and is considered to be the best laboratory model of human hypertension. We extended our previously published model of the rat ventricular myocyte to simulate the effects of hypertrophy in SHR. Methods and Results: In SHR it has been shown that the membrane capacitance is increased, the density of transient outward K+ current is decreased, the sarcoplasmic reticulum Ca 2+ ATPase activity is reduced, and the cell volumes are increased compared to those of the normal rat. We introduced these changes into our previous model of the rat ventricular myocyte and simulated the ventricular action potential of SHR. Our results demonstrated increased action potential duration (APD) and increased peak systolic value of the intracellular calcium transient in SHR. Simulations with reduced extracellular K+ concentration ([K+]o) have shown that there is increased APD shortening in SHR compared to that of the normal rat. Conclusions: Our computational model qualitatively simulated the electrophysiologic changes observed in SHR and provided the plausible mechanistic linkage between the prolonged APD and increased inotropy. Our model results also demonstrated the electrophysiologic changes observed with reduced [K+]o in SHR, a finding that is clinically significant in hypertensive patients with left ventricular hypertrophy undergoing diuretic treatment.
Açıklama
Anahtar Kelimeler
Action potential duration, Action potential, Action potentials, Adenosine triphosphatase (calcium), Adulthood, Animal, Animals, Article, Biological model, Calcium, Calcium cell level, Calcium transient, Calcium transport, Cardiac myocyte, Cell volume, Computational model, Electric capacitance, Enzyme activity, Enzyme assay, Extracellular fluid, Heart electrophysiology, Heart muscle cell, Heart muscle potential, Heart ventricle, Heart ventricle function, Heart ventricle hypertrophy, Heart ventricles, Hypertens, Hypertension, Hypertrophy, Intracellular membrane, Intracellular membranes, Ion channel, Ion channels, Ioninotropism, Kv channel-interacting proteins, Mathematical model, Metabolism, Models, Cardiovascular, Myocytes, Cardiac, Osmolar concentration, Osmolarity, Pathophysiology, Potassium, Potassium channels, Potassium current, Potassium ion, Priority journal, Qualitative analysis, Rat, Rats, Rats, Inbred SHR, Reaction time, Sarcoplasmic reticulum, Simulation, Spontaneously hypertensive rats, Spontaneously hypertensive rat, Systole, Transient outward, Ventricular function, Voltage-gated
Kaynak
Journal of Cardiovascular Electrophysiology
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
14
Sayı
9
Künye
Padmala, S. & Demir, S. S. (2003). Computational model of the ventricular action potential in adult spontaneously hypertensive rats.Journal of Cardiovascular Electrophysiology. 14(9), 990-995. doi:10.1046/j.1540-8167.2003.03086.x
