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The mediating effect of self compassion in the relationship between job stress and burnout levels among employees
(SAGE Publications Inc., 2026-02-13) Günay, Ezgi; Ünver, Buket; Yılmaz, Simay
Objective: This study investigates the role of self-compassion as a mediator in the relationship between job stress and burnout among employees. While job stress is widely recognized as a critical factor leading to burnout, it has been suggested that self-compassion may be associated with a reduction in these negative effects. Method: Participants were 429 actively employed adults living in Turkey (50.6% female). The data were gathered using an online administration of standardized psychological scales, that is, Job Stressor Appraisal Scale, Copenhagen Burnout Scale, and Self-Compassion Scale. Four dimensions of work stress “Role and Workload, Role Inadequacy, Organizational Rules & Practices, and Subordinate Relations” are taken into consideration in the volumetric model. Path analysis with bootstrapping (5,000 resamples) was implemented using Mplus statistical software, with gender, economic condition, and way of working during COVID-19 as covariates. Findings: The model fit was acceptable in path analysis. Role and workload and role inadequacy had a significant direct impact on burnout. Self-compassion had a significant mediating impact on the relationship between role and workload and burnout and the relationship between role inadequacy and burnout. Conversely, for organizational rules and practices and subordinate relations, both direct and mediating effects were non-significant. The model accounted for 21% and 52% for variance in self-compassion and burnout, respectively. Conclusion: This study emphasises the mediating role of self-compassion in the effect of job stressors on burnout. These findings suggest that interventions promoting self-compassion in the workplace may be effective in reducing employee burnout.
Witnessing the end, supporting the living: A qualitative study of palliative caregiving in end-of-life patients in Türkiye
(Cambridge University Press, 2026-02-11) Sert Yurdakul, Selin; Erbay Erşen, Merve; Özel, Dilara
Objectives. Palliative care seeks to enhance the quality of life for individuals with serious illnesses and their families by addressing physical, emotional, and psychological needs. This phenomenological study examines the lived experiences of 8 caregivers in palliative care settings in Türkiye, focusing on the challenges they face, the coping mechanisms they employ, and their reflections on the caregiving role. Special emphasis is given to both psychological and somatic signs of stress, along with the possible advantages of body-oriented resilience techniques. Methods. Using a phenomenological qualitative design, semi-structured interviews were conducted with 8 caregivers providing care to relatives in a hospital-based palliative care unit. Data were collected between February and April 2023 and analyzed through conventional content analysis. Results. Four central themes emerged from inductive coding: harmony in healing, navigating difficulties, resilience in palliative care, and reflections on the finite. The findings reveal a dual reality: palliative caregivers derive meaning and satisfaction from compassionate connections, high-quality clinical care, and peer support, yet they also endure significant burdens, including emotional strain, physical exhaustion, disrupted daily routines, and shifting relational dynamics. Anticipatory grief and chronic stress responses were prevalent, frequently manifesting in both psychological and somatic forms (e.g., sleep disturbances, muscle tension, and autonomic arousal). Despite these challenges, palliative caregivers employed spiritual beliefs, peer interactions, and self-care routines as resilience strategies. Significance of results. The mind–body challenges identified in the study emphasize the need for interventions that focus on self-regulation and resilience, including body-oriented approaches that strengthen internal resources, regulate stress responses, and encourage adaptability. Incorporating such approaches into group-based settings may improve mutual support and enhance both individual and relational well-being. The study highlights the importance of comprehensive, caregiver-centered support systems to reduce burden and improve the overall quality of palliative care.
Validation and normative data study for the Turkish version of the movie for the assessment of social cognition (MASC-TR)
(Oxford University Press, 2026-02-05) Şandor, Serra; Hıdıroğlu-Ongun, Ceren; Tanfer, Mehmet Can; Gürkaş, Sena; Bora, Emre; Yıldırım, Elif
Objective This study aimed to adapt the Movie for the Assessment of Social Cognition (MASC) into Turkish (MASC-TR), examine its psychometric properties, and establish normative data. Additionally, the study investigated the discriminative validity of the MASC-TR in differentiating individuals with autism spectrum disorder (ASD) from healthy controls. Methods The sample comprised 228 healthy adults and 29 individuals with ASD aged 18–45 years. Participants completed the MASC-TR along with established measures of theory of mind (ToM)—the Reading the Mind in the Eyes Test (RMET) and the Faux Pas Recognition Test (FPRT)—as well as non-social cognitive tasks assessing attention, working memory, and executive functions. Reliability analyses included internal consistency and test–retest reliability. Construct validity was assessed via convergent and discriminant correlations. Group comparisons and receiver operating characteristic analyses were used to evaluate discriminative validity, while multifactorial analysis of variance and regression analyses examined demographic effects. Results The MASC-TR demonstrated acceptable internal consistency (α=0.75) and excellent test–retest reliability (ICC=0.98). Significant positive correlations with RMET and FPRT supported convergent validity. Education level emerged as the only significant demographic predictor of MASC-TR performance. The MASC-TR successfully differentiated individuals with ASD from controls (t=−3.87, p<.001), with an optimal cutoff of 23.5 yielding 97% sensitivity and 52% specificity (area under the curve=0.72). Conclusions The findings indicate that the MASC-TR is a valid and reliable measure of social cognition in Turkish adults. The availability of culturally adapted normative data enhances its clinical and research utility for assessing ToM functioning across populations.
Architects' journeys to Italy and their contribution to architectural culture in postwar-era Turkey
(Cambridge University Press, 2024-12) Hamiloğlu, Ceren; Özsoy, Ahsen
In the twentieth century, the mobility of architects and ideas played an important role in the dissemination of an architecture culture characterised by modernity. Architectural ideas were disseminated through institutions and a variety of visual, verbal, and textual representations as well as physical encounters. Travel, with its associated architectural thinking and representation, became a generative practice through which the dissemination of architecture could be understood. The Grand Tour was one of the most well-studied examples of travel as a rite of passage, and Italy remained a dominant destination long after its peak in the eighteenth century. Italian architectural discourse entered Turkey through travels and publications, mostly in the prewar era. This article aims to show the role of architects’ travels in inducing architectural productions through a variety of representations from sketches to published media, scrutinising Turkish-speaking architects’ journeys to Italy in the postwar era. The study incorporates content analysis of selected media - such as photographs, articles, class notes, books, and memoirs - to review architects’ productions during and after their travels, as they facilitated the dissemination of an architecture culture ‘brought back’ after key experiences.
Energy-based characterization of drilling-induced residual stresses in AA7075-T6
(Multidisciplinary Digital Publishing Institute (MDPI), 2026-01) Tok, Görkem; Dinçer, Ammar Tarık; Bakkal, Mustafa; Kuzu, Ali Taner
This study examines the influence of drilling parameters on thrust force, torque, active work, and axial residual stress formation in hot-forged and T6-treated AA7075, a critical high-strength aluminum alloy. A full factorial design was applied using three spindle speeds (800, 1000, 1200 rpm) and three feed rates (0.05, 0.10, 0.15 mm/rev). Cutting force and torque signals were measured using a dynamometer, and axial residual stresses were determined by X-ray diffraction at two locations along the hole depth, namely, the hole entrance (Point A) and the hole exit (Point B). The results show that feed rate is the dominant factor influencing drilling mechanics and residual stress formation, whereas spindle speed mainly affects the thermal and frictional conditions governing stress relaxation. A consistent asymmetry was observed between the two measurement locations, with the exit side exhibiting stronger stress relaxation behavior associated with breakthrough mechanics. Finally, the relationship between active work and axial residual stress is discussed using a qualitative, energy-based interpretation, highlighting active work as a physically meaningful indicator for drilling-induced residual stress evolution.
Formal thought disorder and familial risk in first-episode psychosis: A study of cortical thickness and neuroimaging-transcriptomic association analysis
(Elsevier Ireland Ltd, 2026-01-16) Çabuk, Tuğçe; Zhang, Yuanchao; Palaniyappan, Lena; Şahin Çevik, Didenur; Avcı, Hanife; Çakmak, Işık Batuhan; Yılmaz Kafalı, Helin; Şenol, Bedirhan; Karlı Oğuz, Kader; Toulopoulou, Timothea
Formal thought disorder (FTD), a prominent feature of schizophrenia, encompasses disruptions in thought, language, and communication. This study examines cortical thickness (CT) alterations in first-episode psychosis (FEP) patients (N = 24), their siblings (SIB) (N = 21), and healthy controls (CON) (N = 21) to explore potential neural correlates of FTD. Using structural MRI, we analyzed whole-brain CT and its relationship with positive and negative FTD measured by Thought and Language Index. Out-of-sample spatial correlations of gene expression with regional CT were also performed using a transcriptomic dataset. FEP had significant CT reductions in right middle frontal gyrus (MFG) compared with SIB and CON and in superior frontal gyrus (SFG) compared to CON; but SIB did not differ from CON. GLM analyses demonstrated that negative FTD exerted a significant main effect on CT in the MFG and SFG. By contrast, positive FTD showed no significant associations with CT. Neuroimaging-transcriptomic association analysis identified key biological pathways linked to cortical morphology. These findings emphasize the specific association between negative FTD and CT alterations in frontal brain regions, confirming prior reports. Future research should examine larger cohorts and investigate additional FTD subtypes to further elucidate neural correlates and potential familial risks of schizophrenia.
Future circular collider feasibility study report: volume 1 physics, experiments, detectors
(Springer Nature, 2025-12) Benedikt, Michael; Zimmermann, Frank; Auchmann, Bernhard; Bartmann, Wolfgang; Burnet, Jean Paul; Bayındır, Cihan
Volume 1 of the FCC Feasibility Report presents an overview of the physics case, experimental programme, and detector concepts for the Future Circular Collider (FCC). This volume outlines how FCC would address some of the most profound open questions in particle physics, from precision studies of the Higgs and EW bosons and of the top quark, to the exploration of physics beyond the Standard Model. The report reviews the experimental opportunities offered by the staged implementation of FCC, beginning with an electron-positron collider (FCC-ee), operating at several centre-of-mass energies, followed by a hadron collider (FCC-hh). Benchmark examples are given of the expected physics performance, in terms of precision and sensitivity to new phenomena, of each collider stage. Detector requirements and conceptual designs for FCC-ee experiments are discussed, as are the specific demands that the physics programme imposes on the accelerator in the domains of the calibration of the collision energy, and the interface region between the accelerator and the detector. The report also highlights advances in detector, software and computing technologies, as well as the theoretical tools/reconstruction techniques that will enable the precision measurements and discovery potential of the FCC experimental programme. The content and structure of this report are guided by the scope and priorities defined in the mandate of the FCC Feasibility Study. It is therefore not intended to serve as an exhaustive review of the full physics potential of FCC. Several topics, already covered in earlier reports such as the FCC CDR, are not reiterated here or are addressed only briefly, in alignment with the study’s focus. This volume reflects the outcome of a global collaborative effort involving hundreds of scientists and institutions, aided by a dedicated community-building coordination, and provides a targeted assessment of the scientific opportunities and experimental foundations of the FCC programme.
TURSpider veri kümesinde Temsilcilerin Karışımı Tabanlı Text-to-SQL çalışması
(IEEE, 2025) Kanburoğlu, Ali Buğra; Tek, Faik Boray
Bu çalışma, Türkçe Text-to-SQL için geliştirilen TURSpider veri kümesi üzerindeki deneyleri ele almaktadır. TURSpider, çeşitli zorluk seviyelerine sahip SQL sorgularını içeren geniş kapsamlı bir Türkçe veri kümesidir ve bu alandaki araştırmalar için önemli bir kaynak niteliğindedir. Çalışmada, geri bildirim odaklı temsilcilerin karışımı yaklaşımının (ing. feedback driven Mixture-of-Agents - MoAF) başarımı incelenmiştir. MoAF yapısında, birden fazla büyük dil modeli (BDM) iş birligi içinde çalışarak SQL oluşturma başarımını artırmayı hedeflemektedir. Bu yapıda temsilci (ing. agent) işbirliği, modellerin birbirinden ögrenmesini ve geri bildirim mekanizmaları aracılığıyla hataların düzeltilmesini sağlamaktadır. Deney sonuçlarına göre, MoAF yaklaşımı ile %60.63 yürütme doğruluğuna ulaşılmış ve TURSpider veri kümesi üzerindeki en iyi sonuç elde edilmiştir.
Effects of transcranial direct current stimulation on inhibition-related oscillatory brain activity during an emotional antisaccade task
(Kare Publishing, 2025-12) Sütçübaşı, Bernis; Küçük, Zeynep; Tarman, Güliz Zeynep; Metin, Barış; Sarı, Berna
Objective: Previous studies have shown that transcranial direct current stimulation (tDCS) applied to the dorsolateral prefrontal cortex (dlPFC) can enhance attentional performance and influence emotional processing. However, the neural mechanisms underlying these effects are not fully understood. This study aimed to investigate oscillatory changes following tDCS over the dlPFC, with the hypothesis that anodal stimulation of the right dlPFC would modulate inhibition-related oscillations in the presence of threatening faces compared with left dlPFC stimulation. Method: Thirty-six healthy participants underwent bilateral tDCS to the dlPFC. One group received anodal tDCS to the right dlPFC and cathodal to the left dlPFC, while the second group received the opposite montage. A control group received sham stimulation. Before and after stimulation, behavioral performance and event-related theta oscillations were recorded during an antisaccade task involving neutral and angry faces. Results: Compared to the left-dlPFC group, the right-dlPFC group showed lower theta responses at F3 after anodal stimulation, particularly during antisaccade trials with angry faces, which are known to impose higher inhibitory demands due to threat salience. No group differences were found in saccade latencies. These findings suggest that anodal right dlPFC stimulation modulates oscillatory activity related to inhibitory control under emotionally salient conditions. Conclusion: A decrease in theta oscillations following anodal tDCS over the right dlPFC may indicate enhanced inhibitory control during the processing of threatening stimuli. These results point to a potential role of dlPFC-targeted tDCS in regulating cognitive control and emotional processing, particularly in individuals with difficulties in these domains. However, the directionality and causality of these effects cannot be conclusively established due to limitations of the current study design.
Theta and Beta1 frequency band values predict dyslexia classification
(John Wiley and Sons Ltd, 2025-12-29) Eroğlu, Günet; Harb, Mhd Raja Abou
Dyslexia, impacting children's reading skills, prompts families to seek cost-effective neurofeedback therapy solutions. Utilising machine learning, we identified predictive factors for dyslexia classification. Employing advanced techniques, we gathered 14-channel Quantitative Electroencephalography (QEEG) data from 200 participants, achieving 99.6% dyslexic classification accuracy through cross-validation. During validation, 48% of dyslexic children's sessions were consistently classified as normal, with a 95% confidence interval of 47.31 to 48.68. Focusing on individuals consistently diagnosed with dyslexia during therapy, we found that dyslexic individuals exhibited higher theta values and lower beta1 values compared to typically developing children. This study pioneers machine learning in predicting dyslexia classification factors, offering valuable insights for families considering neurofeedback therapy investment.
Design of voltage-mode and current-mode PID controllers using a single Add-Differentiate IC (AD-IC)
(Birkhauser, 2025-12-22) Minayi, Elham; Göknar, İzzet Cem
In this paper, voltage and current mode proportional–integral–derivative (PID) controller circuits are presented in one topology, utilizing only a single active component, Add-Differentiate Integrated Circuit (AD-IC) along with two passive resistors and two passive capacitors. The effectiveness and performance of the proposed circuits are validated through sensitivity, non-ideality analyses and PSPICE and MatLab simulations.
Effect of modulated anodal stimulation over the dorsolateral prefrontal cortex on working memory: a preliminary study
(Istanbul University, 2025-12-31) Küçük, Zeynep; Erdoğan, Ezgi Tuna; Kurt, Adnan; Karamürsel, Sacit
Objectives: Working memory has two components: temporary storage and manipulation of the information necessary for cognitive behavior through the central executive system. This study aimed to investigate the effects of modulated anodal transcranial direct current stimulation (mtDCS) of the dorsolateral prefrontal cortex on working memory. Materials and Methods: Twelve volunteers without neurological or psychiatric disorders and without drug use participated. Working memory performance was assessed with a visual 3-back task using consonant letters during stimulation. A 20/minute training session was conducted to facilitate learning, and participants who achieved an accuracy rate of 50% or higher proceeded to the main experiment. Four stimulation conditions were applied, each lasting 10 minutes: mtDCS-11 Hz and mtDCS-22 Hz (1.70 mA offset, 0.35 mA peak/to/peak), direct current (DC) (2 mA), and sham. Reaction times and total correct responses were recorded. Results: Statistical analysis of the left dorsolateral prefrontal cortex (DLPFC) stimulation revealed a significant difference in the mean numbers of correct responses among the mtDCS and transcranial direct current stimulation (tDCS) conditions, but not compared with sham. The mean number of correct responses under mtDCS-11Hz and mtDCS-22Hz was significantly lower than under DC stimulation; however the performance decrement under 11 Hz mtDCS was the most pronounced among the active conditions. Conclusion: mtDCS-11Hz and mtDCS-22Hz negated the subtle facilitation of tDCS might have provided.
Performance outcomes of supply chain management practices: evidence from Pakistan's fan manufacturing SMEs
(University of Novi Sad, 2025-12-01) Akbay, Ümmühan; Hafeez, Muhammad Salman
This study examines the impact of supply chain management practices on the organization’s marketing and financial performance. We present the results of a survey conducted with 100 Pakistani fan manufacturing firms. Statistical analysis reveals that the industry struggles with information sharing and joint operations within the supply chain. PLS-SEM analysis of the survey data shows that supply chain performance is significantly correlated with organizational performance. Both customer and supplier relationship management have positive and significant effects on the performance of the supply chain and the organization. However, the impact of customer relationship management is stronger as its path coefficient is greater. Additionally, although internal supply chain management also impacts both supply chain and organization performance positively, the impact is slightly short of being statistically significant. This study contributes to the supply chain management literature by providing empirical evidence from an understudied manufacturing sector from a developing country.
Healing through art: a systematic review and meta-analysis of art therapy in children and adolescents with chronic illnesses
(Taylor and Francis Ltd., 2025-11) Yıldız, Ecemnur; Akçinar, Berna; İnci Namlı, Nur
Children and adolescents with chronic illnesses face elevated risks of psychological difficulties, including anxiety and reduced quality of life (QoL). Art therapy (AT) has emerged as a promising intervention. This study systematically reviews and analyzes the effectiveness of AT in improving QoL, anxiety, and pain in this population. A comprehensive search identified a total of 12 randomized controlled trials from 2000 to 2024, including 408 participants aged 0–18. Data were analyzed using Hedges’ g and a random-effects model. Quality assessments followed the Cochrane Risk of Bias 2 (RoB2) tool. Subgroup analyses explored potential moderators. QoL was analyzed separately by child and parent reports. AT showed a moderate, significant effect on child-reported QoL (Hedges’ g =.40, 95% CI [0.27; 0.53], p =.001) but a non-significant effect in parent reports (Hedges’ g =.43, 95% CI [−.03; 1.20], p =.21). A significant large effect was found for pain reduction (Hedges’ g = –.63, 95% CI [−1.19; −0.07], p =.03). For anxiety, AT had a large but non-significant effect (Hedges’ g = –.71, 95% CI [−2.24; 0.82], p =.23). Heterogeneity was substantial, but no significant publication bias was detected. AT appears promising for enhancing QoL, reducing pain in children with chronic illnesses. Further studies are needed to strengthen evidence and clarify clinical applications.
Complex rays and applications
(Işık University Press, 2025-12-01) Hasanoğlu, Elman
Complex rays are a fascinating aspect of modern diffraction theory, typically sought as complex solutions to the eikonal equation. Traditionally, these solutions are obtained by analytically continuing real rays into the complex domain. However, this approach demands the analyticity of initial data, significantly limiting its applicability to many practical problems. Additionally, unlike real rays, complex rays cannot be visualized in space, presenting another drawback. In this paper, we present an alternative interpretation of complex rays, as introduced in [1], and describe a novel approach to two model diffraction problems and Gaussian beams.
Büyük Dil Modelleri için TR-MMLU Benchmark’ı: performans değerlendirmesi, zorluklar ve iyileştirme fırsatları
(Cornell Univ, 2025-08-18) Bayram, M. Ali; Fincan, Ali Arda; Gümüş, Ahmet Semih; Diri, Banu; Yıldırım, Savaş; Aytaş, Öner
Dil modelleri, insan dilini anlama ve üretme konularında önemli ilerlemeler kaydetmiş, birçok uygulamada dikkat çekici başarılar elde etmiştir. Ancak, özellikle Türkçe gibi kaynak açısından sınırlı dillere yönelik değerlendirme çalışmaları önemli bir zorluk oluşturmaktadır. Bu sorunu ele almak amacıyla, büyük dil modellerinin (LLM) Türkçe dilindeki dilsel ve kavramsal yeteneklerini değerlendirmek için kapsamlı bir değerlendirme çerçevesi olan Türkçe MMLU (TR-MMLU) benchmark’ını tanıttık. TR-MMLU, Türk eğitim sisteminden 62 bölümdeki 6.200 çoktan seçmeli soruyu içeren, özenle hazırlanmış bir veri setine dayanmaktadır. Bu benchmark, Türkçe doğal dil işleme (NLP) araştırmalarına standart bir çerçeve sunmakta ve büyük dil modellerinin Türkçe metinleri işleme yeteneklerini detaylı bir şekilde analiz etmeyi sağlamaktadır. Çalışmamızda, TR-MMLU üzerinde en güncel büyük dil modellerini değerlendirdik ve model tasarımında iyileştirme gerektiren alanları vurguladık. TRMMLU, Türkçe NLP araştırmalarını ilerletmek ve gelecekteki yeniliklere ilham vermek için yeni bir standart oluşturmaktadır.
Geopolitical parallax: beyond Walter Lippmann just after large language models
(Cornell Univ, 2025-08-27) Yavuz, Mehmet Can; Kabir, Humza Gohar; Özkan, Aylin
Objectivity in journalism has long been contested, oscillating between ideals of neutral, fact-based reporting and the inevitability of subjective framing. With the advent of large language models (LLMs), these tensions are now mediated by algorithmic systems whose training data and design choices may themselves embed cultural or ideological biases. This study investigates geopolitical parallax—systematic divergence in news quality and subjectivity assessments—by comparing articlelevel embeddings from Chinese-origin (Qwen, BGE, Jina) and Western-origin (Snowflake, Granite) model families. We evaluate both on a human-annotated news quality benchmark spanning fifteen stylistic, informational, and affective dimensions, and on parallel corpora covering politically sensitive topics, including Palestine and reciprocal China–United States coverage. Using logistic regression probes and matched-topic evaluation, we quantify per-metric differences in predicted positive-class probabilities between model families. Our findings reveal consistent, nonrandom divergences aligned with model origin. In Palestinerelated coverage, Western models assign higher subjectivity and positive emotion scores, while Chinese models emphasize novelty and descriptiveness. Cross-topic analysis shows asymmetries in structural quality metrics—Chinese-on-US scoring notably lower in fluency, conciseness, technicality, and overall quality—contrasted by higher negative emotion scores. These patterns align with media bias theory and our distinction between semantic, emotional, and relational subjectivity, and extend LLM bias literature by showing that geopolitical framing effects persist in downstream quality assessment tasks. We conclude that LLMbased media evaluation pipelines require cultural calibration to avoid conflating content differences with model-induced bias.
Efficacy, all-cause discontinuation, and safety of serotonergic psychedelics and MDMA to treat mental disorders: a living systematic review with meta-analysis
(Elsevier B.V., 2025-12) Højlund, Mikkel; Yılmaz Kafalı, Helin; Kırmızı, Begüm; Fusar-Poli, Paolo; Correll, Christoph U.; Cortese, Samuele; Sabé, Michel; Fiedorowicz, Jess; Saraf, Gayatri; Zein, Josephine; Berk, Michael; Husain, Muhammad I.; Rosenblat, Joshua D.; Rubaiyat, Ruby; Corace, Kim; Wong, Stanley; Hatcher, Simon; Kaluzienski, Mark; Yatham, Lakshmi N.; Cipriani, Andrea; Gosling, Corentin J.; Carhart-Harris, Robin; Tanuseputro, Peter; Myran, Daniel T.; Fabiano, Nicholas; Moher, David; Mayo, Leah M.; Nicholls, Stuart G.; White, Tracy; Prisco, Michele De; Radua, Joaquim; Vieta, Eduard; Ladha, Karim S.; Katz, Jay; Veroniki, Areti A.; Solmi, Marco
Serotonergic psychedelics and 3,4-methylendioxtmethamphetamine (MDMA) are promising treatments for mental disorders with a continuously evolving evidence base. We searched Pubmed/Scopus/clinical trial registries up to 08july2025 for double-blind randomized controlled trials (RCTs) testing MDMA or serotonergic psychedelics in patients with mental disorders. Primary outcomes were change in disease-specific symptoms and all-cause discontinuation. Standardized mean differences (SMD) and relative risk (RR) were estimated using random-effects meta-analysis. Risk of bias (RoB) was assessed with Cochrane’s RoB-tool version 2 and certainty of evidence with GRADE. The review is maintained as living systematic review ( https://ebipsyche-database.org/ ). We included 30 RCTs (1480 participants; female=45.8 %; with psychological support=83.3 %; high RoB=83.3 %). In post-traumatic stress disorder (PTSD), MDMA reduced PTSD symptoms compared to any control ( k = 11; SMD=-0.85 [-1.09; -0.60]; I2=0 %; GRADE=low). In major depressive disorder (MDD), psilocybin/ayahuasca/LSD reduced depressive symptoms ( k = 8; SMD=-0.62 [-0.97; -0.28]; I2=55 %; GRADE=very low). In anxiety disorders, both MDMA and serotonergic psychedelics reduced anxiety symptoms (SMDMDMA=-1.18 [-2.04; -0.32]; I2=0 %; k = 2; GRADE=low and SMDserotonergic=-0.88 [-1.70; -0.06]; I2=54 %; k = 5; GRADE=very low). In alcohol use disorder, neither psilocybin nor LSD reduced abstinence rates ( k = 6; RR=1.42 [0.89; 2.26]; I2=7 %; GRADE=very low). In attention-deficit hyperactivity disorder (ADHD), LSD did not reduce ADHD symptoms ( k = 1; SMD=0.22 [-0.32; 0.76]; GRADE=very low). Moderate certainty in evidence was only found for MDMA on PTSD symptoms when compared to placebo. MDMA/serotonergic psychedelics were not associated with higher risk of all-cause discontinuation (RRMDMA=0.74 [0.32; 1.72]; RRserotonergic=0.81 [0.56; 1.15]). Overall, MDMA/serotonergic psychedelics are promising for the treatment of PTSD, MDD, and anxiety disorders with moderate to large effect sizes. Pragmatic trials, long-term, head-to-head trials exploring the role of psychological support, aiming to identify predictors of response, and accounting for expectancy and functional unblinding are needed. Studies addressing these limitations will likely be required for regulatory approval of psychedelic drugs.
Designing a scalable agricultural information system for pest detection and decision support in hazelnut cultivation
(World Scientific Publishing Company, 2025-11-12) Aydın, Şahin
This study presents a microservices-based, multi-tiered information system to detect, monitör and manage pest species that cause yield losses in hazelnut production. The system integrates a deep learning model for classifying pest images submitted by field users, the generation of pest density maps and location-based early warning mechanisms for growers. Delivered through mobile, web and desktop platforms, the system enables data sharing among farmers, researchers and decision-makers, supporting agricultural decisions. Experimental findings show that the DNN+ResNet50 architecture achieved the highest accuracy (91.88%) among all tested CNN models. Performance evaluations indicated that the Authentication and Heatmap services sustained high stability under loads of up to 1000 requests, while the Bug Classification Service was reliable up to 750 requests before reaching a critical resource threshold. The usability test resulted in an overall score of 38 out of 50, with sub-scores of Appropriateness Recognizability (0.73, Acceptable), Learnability (0.71, Acceptable), Operability (0.65, Questionable), User Error Protection (0.86, Good), User Interface Aesthetics (0.83, Good) and Accessibility (0.74, Acceptable). With its robust technical architecture and practical implementation, the proposed system can generate economic, social and commercial outcomes. This study provides a software engineering-oriented approach to the digitalization of agricultural production and the sustainable management of pests.
Predictive modelling of surface roughness and residual stress induced by milling of hot forged and heat treated AA7075
(Springer Nature, 2025-11-03) Tok, Görkem; Dinçer, Ammar Tarık; Kuzu, Ali Taner; Bakkal, Mustafa
This study investigates the influence of cutting parameters on residual stress and surface roughness during the milling of hot-forged and T6 heat-treated AA7075 components. Using Taguchi L9 and full-factorial experimental designs and regression modelling, the research highlights important relationships between cutting parameters (cutting speed, feed rate, and depth of cut), residual stress and surface roughness. Higher cutting speeds (350 m/min) and lower feed rates (0.1 mm/tooth) significantly minimized residual stresses, with hoop stress values decreasing from 108.7 MPa at lower speeds (150 m/min) to approximately 73.4 MPa at higher speeds, and axial stress values ranging from 45.9 MPa to 88.5 MPa. Surface roughness (Ra) was most influenced by feed rate, with measurement values varying between 0.25 mu m and 0.92 mu m. Support Vector Regression (SVR) demonstrated better accuracy for predicting residual stress (MAPE: 11.5%) and surface roughness (MAPE: 7%), outperforming Lasso and Ridge regression models. These findings provide a consistent framework for optimizing cutting parameters and enhancing residual stress and surface roughness in AA7075 machining processes, offering practical implications for improving component performance and manufacturing efficiency.

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