A novel approach to non-invasive intracranial pressure wave monitoring: a pilot healthy brain study

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dc.authorid0000-0001-5835-5697
dc.authorid0000-0002-2460-4277
dc.authorid0009-0004-6467-9064
dc.authorid0000-0002-7360-5276
dc.authorid0000-0002-1343-5068
dc.authorid0000-0002-8964-0738
dc.authorid0009-0009-5153-1200
dc.authorid0009-0000-6891-1351
dc.authorid0000-0002-2660-7922
dc.authorid0000-0001-9695-9512
dc.contributor.authorKaraliunas, Andriusen_US
dc.contributor.authorBartusis, Laimonasen_US
dc.contributor.authorKrakauskaite, Solventaen_US
dc.contributor.authorChaleckas, Edvinasen_US
dc.contributor.authorDeimantavicius, Mantasen_US
dc.contributor.authorHamarat, Yasinen_US
dc.contributor.authorPetkus, Vytautasen_US
dc.contributor.authorStulge, Tomaen_US
dc.contributor.authorRatkunas, Vytenisen_US
dc.contributor.authorÇelikkaya, Güvenen_US
dc.contributor.authorJanuleviciene, Ingridaen_US
dc.contributor.authorRagauskas, Arminasen_US
dc.date.accessioned2025-09-16T07:55:06Z
dc.date.available2025-09-16T07:55:06Z
dc.date.issued2025-06-28
dc.departmentIşık Üniversitesi, Sanat, Tasarım ve Mimarlık Fakültesi, Görsel İletişim Tasarımı Bölümüen_US
dc.departmentIşık University, Faculty of Art, Design And Architecture, Department of Visual Communication Designen_US
dc.descriptionThis research was supported by the Research Council of Lithuania under Grant Agreements No. S-PD-24-154 and SV5-40 (S-MIP-23-136).en_US
dc.description.abstractIntracranial pressure (ICP) pulse wave morphology, including the ratios of the three characteristic peaks (P1, P2, and P3), offers valuable insights into intracranial dynamics and brain compliance. Traditional invasive methods for ICP pulse wave monitoring pose significant risks, highlighting the need for non-invasive alternatives. This pilot study investigates a novel non-invasive method for monitoring ICP pulse waves through closed eyelids, using a specially designed, liquid-filled, fully passive sensor system named ‘Archimedes 02’. To our knowledge, this is the first technological approach that enables the non-invasive monitoring of ICP pulse waveforms via closed eyelids. This study involved 10 healthy volunteers, aged 26–39 years, who underwent resting-state non-invasive ICP pulse wave monitoring sessions using the ‘Archimedes 02’ device while in the supine position. The recorded signals were processed to extract pulse waves and evaluate their morphological characteristics. The results indicated successful detection of pressure pulse waves, showing the expected three peaks (P1, P2, and P3) in all subjects. The calculated P2/P1 ratios were 0.762 (SD = ±0.229) for the left eye and 0.808 (SD = ±0.310) for the right eye, suggesting normal intracranial compliance across the cohort, despite variations observed in some individuals. Physiological tests—the Valsalva maneuver and the Queckenstedt test, both performed in the supine position—induced statistically significant increases in the P2/P1 and P3/P1 ratios, supporting the notion that non-invasively recorded pressure pulse waves, measured through closed eyelids, reflect intracranial volume and pressure dynamics. Additionally, a transient hypoemic/hyperemic response test performed in the upright position induced signal changes in pressure recordings from the ‘Archimedes 02’ sensor that were consistent with intact cerebral blood flow autoregulation, aligning with established physiological principles. These findings indicate that ICP pulse waves and their dynamic changes can be monitored non-invasively through closed eyelids, offering a potential method for brain monitoring in patients for whom invasive procedures are not feasible.en_US
dc.description.sponsorshipLietuvos Mokslo Tarybaen_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationKaraliunas, A., Bartusis, L., Krakauskaite, S., Chaleckas, E., Deimantavicius, M., Hamarat, Y., Petkus, V., Stulge, T., Ratkunas, V., Çelikkaya, G., Januleviciene, I. & Ragauskas, A. (2025). A novel approach to non-invasive intracranial pressure wave monitoring: a pilot healthy brain study. Sensors, 25(13), 1-20. doi:en_US
dc.identifier.doi10.3390/s25134042
dc.identifier.endpage20
dc.identifier.issn1424-8220
dc.identifier.issue13
dc.identifier.pmid40648297
dc.identifier.scopus2-s2.0-105010310816
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/11729/6705
dc.identifier.urihttps://doi.org/10.3390/s25134042
dc.identifier.volume25
dc.identifier.wosWOS:001527638500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScience Citation Index Expanded (SCI-EXPANDED)en_US
dc.institutionauthorÇelikkaya, Güvenen_US
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en_US
dc.relation.ispartofSensorsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHealthy volunteer studyen_US
dc.subjectIntracranial complianceen_US
dc.subjectIntracranial pressure wavesen_US
dc.subjectNon-invasive monitoringen_US
dc.subjectPulse wave morphologyen_US
dc.subjectAdulten_US
dc.subjectBrainen_US
dc.subjectFemaleen_US
dc.subjectHealthy volunteersen_US
dc.subjectHumansen_US
dc.subjectIntracranial pressureen_US
dc.subjectMaleen_US
dc.subjectMonitoringen_US
dc.subjectPhysiologicen_US
dc.subjectPilot projectsen_US
dc.subjectPulse wave analysisen_US
dc.subjectBlooden_US
dc.subjectMorphologyen_US
dc.subjectPatient monitoringen_US
dc.subjectSignal processingen_US
dc.subjectPressure pulseen_US
dc.subjectPressure wavesen_US
dc.subjectPulse-waveen_US
dc.subjectNormal humanen_US
dc.subjectPhysiologic monitoringen_US
dc.subjectPhysiologyen_US
dc.subjectPilot studyen_US
dc.subjectProceduresen_US
dc.subjectNoninvasive medical proceduresen_US
dc.titleA novel approach to non-invasive intracranial pressure wave monitoring: a pilot healthy brain studyen_US
dc.typeArticleen_US
dspace.entity.typePublicationen_US

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