Associations between cerebral perfusion pressure, hemodynamic parameters, and cognitive test values in normal-tension glaucoma patients, Alzheimer’s disease patients, and healthy controls

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dc.authorid0000-0002-6793-8066
dc.authorid0009-0004-6467-9064
dc.authorid0009-0003-1900-3391
dc.authorid0000-0001-5835-5697
dc.authorid0000-0002-2660-7922
dc.authorid0000-0001-9695-9512
dc.authorid0000-0002-1343-5068
dc.contributor.authorStoskuviene, Akvileen_US
dc.contributor.authorChaleckas, Edvinasen_US
dc.contributor.authorGrusauskiene, Evelinaen_US
dc.contributor.authorBartusis, Laimonasen_US
dc.contributor.authorÇelikkaya, Güvenen_US
dc.contributor.authorJanuleviciene, Ingridaen_US
dc.contributor.authorVaitkus, Antanasen_US
dc.contributor.authorRagauskas, Arminasen_US
dc.contributor.authorHamarat, Yasinen_US
dc.date.accessioned2025-09-12T08:45:51Z
dc.date.available2025-09-12T08:45:51Z
dc.date.issued2025-05-24
dc.departmentIşık Üniversitesi, Sanat, Tasarım ve Mimarlık Fakültesi, Görsel İletişim Tasarımı Bölümüen_US
dc.departmentIşık University, Faculty of Art, Design And Architecture, Department of Visual Communication Designen_US
dc.descriptionThe Research Council of Lithuania supported this research under Grant Agreement No. SV5-40 (S-MIP-23-136). L.B. and I.J. received support. The funders had no role in the design of the study, the collection, analysis, or interpretation of data, the writing of the manuscript, or the decision to publish the results.en_US
dc.description.abstractBackground/Objectives: Glaucoma and Alzheimer’s disease (AD) are neurodegenerative conditions with vascular underpinnings. This study aimed to explore the relationship between blood pressure parameters such as mean arterial pressure (MAP), pulse pressure (PP), and cerebral perfusion pressure (CPP) and cognitive performance in patients with AD, normal-tension glaucoma (NTG), and healthy controls. We hypothesized that NTG patients, like those with mild cognitive impairment (MCI), may experience subtle cognitive changes related to vascular dysregulation. Methods: Ninety-eight participants (35 NTG, 17 AD, 46 controls) were assessed for CPP, MAP, OPP, and cognitive performance. Statistical analyses compared groups and examined correlations. Results: AD patients showed lower CPP and MAP (p < 0.001), indicating systemic vascular dysfunction, while NTG patients had higher ocular perfusion pressure (OPP) (p = 0.008), suggesting compensatory mechanisms. CPP correlated with visuospatial abilities in AD (r = 0.492, p = 0.045). MAP correlated with the Clock drawing test (CDT) scores in the NTG group (r = 0.378, p = 0.025). PP negatively correlated with cognition in AD (r = −0.527, p = 0.016 for CDT scores) and controls (r = −0.440, p = 0.002 for verbal fluency and r = −0.348, p = 0.019 for total ACE scores). Conclusions: The study highlights distinct hemodynamic profiles: systemic dysfunction in AD and localized dysregulation in NTG. These findings emphasize the role of vascular dysregulation in neurodegeneration, with implications for personalized treatment approaches targeting vascular health in neurodegenerative conditions.en_US
dc.description.sponsorshipLietuvos Mokslo Tarybaen_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationStoskuviene, A., Chaleckas, E., Grusauskiene, E., Bartusis, L., Çelikkaya, G., Januleviciene, I., Vaitkus, A., Ragauskas, A. & Hamarat, Y. (2025). Associations between cerebral perfusion pressure, hemodynamic parameters, and cognitive test values in normal-tension glaucoma patients, Alzheimer’s disease patients, and healthy controls. Medicina (Lithuania), 61(6), 1-14. doi:https://doi.org/10.3390/medicina61060972en_US
dc.identifier.doi10.3390/medicina61060972
dc.identifier.endpage14
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue6
dc.identifier.pmid40572660
dc.identifier.scopus2-s2.0-105009147711
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/11729/6697
dc.identifier.urihttps://doi.org/10.3390/medicina61060972
dc.identifier.volume61
dc.identifier.wosWOS:001516234400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScience Citation Index Expanded (SCI-EXPANDED)en_US
dc.institutionauthorÇelikkaya, Güvenen_US
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en_US
dc.relation.ispartofMedicina (Lithuania)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectCerebral perfusion pressureen_US
dc.subjectCognitive testen_US
dc.subjectNormal tension glaucomaen_US
dc.subjectAgeden_US
dc.subject80 and overen_US
dc.subjectBlood pressureen_US
dc.subjectCerebrovascular circulationen_US
dc.subjectCognitionen_US
dc.subjectCognitive dysfunctionen_US
dc.subjectFemaleen_US
dc.subjectHemodynamicsen_US
dc.subjectHumansen_US
dc.subjectLow tension glaucomaen_US
dc.subjectMaleen_US
dc.subjectMiddle ageden_US
dc.subjectNeuropsychological testsen_US
dc.subjectBrain circulationen_US
dc.subjectcognitive Defecten_US
dc.subjectComplicationen_US
dc.subjectNeuropsychological assessmenten_US
dc.subjectPathophysiologyen_US
dc.subjectPhysiologyen_US
dc.subjectPsychologyen_US
dc.subjectVery elderlyen_US
dc.subjectOpen-angle glaucomaen_US
dc.subjectNeurodegenerationen_US
dc.subjectMetaanalysisen_US
dc.subjectPathwaysen_US
dc.subjectStressen_US
dc.subjectRisken_US
dc.titleAssociations between cerebral perfusion pressure, hemodynamic parameters, and cognitive test values in normal-tension glaucoma patients, Alzheimer’s disease patients, and healthy controlsen_US
dc.typeArticleen_US
dspace.entity.typePublicationen_US

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