Aesculus hippocastanum alleviates diabetic neuropathy by reducing MMP-9 and MMP-10 levels

Basit Öğe Kaydı
dc.contributor.authorGönüllü, Edipen_US
dc.contributor.authorDağıstan, Gözdeen_US
dc.contributor.authorÖzsezer, Yakupen_US
dc.contributor.authorErdoğan, Mümin Alperen_US
dc.contributor.authorErbaş, Oytunen_US
dc.date.accessioned2024-03-15T18:44:58Z
dc.date.available2024-03-15T18:44:58Z
dc.date.issued2023
dc.departmentIşık Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.departmentIşık University, Faculty of Engineering and Natural Sciences, Department of Biomedical Engineeringen_US
dc.description.abstractBackground and Objective: Diabetic neuropathy (DN) is a prevalent complication of diabetes, characterized by neuropathic pain and motor dysfunction. The role of oxidative stress and inflammation in DN pathophysiology is well-documented. This study aims to evaluate the therapeutic potential of Aesculus hippocastanum (AH) in mitigating DN symptoms, focusing on its antioxidant and anti-inflammatory properties. Materials and Methods: The study utilized 40 adult male Wistar rats, divided into four groups: Control, diabetic and two AH-treated groups (receiving 10 mg kgG1 and 20 mg kgG1 AH, respectively). Diabetes was induced using streptozotocin (STZ) injections. Evaluations included lipid peroxidation (via malondialdehyde levels), matrix metalloproteinases (MMP-9 and MMP-10) levels, electrophysiological records (assessing compound muscle action potential), histopathological examination of the sciatic nerve and motor function tests (using an inclined plane). Results: The AH-treated groups exhibited a significant reduction in MDA levels, indicating decreased lipid peroxidation. Plasma MMP-9 and MMP-10 levels were also lower in these groups, suggesting reduced inflammation. Electrophysiological records showed increased CMAP amplitudes and decreased distal latency in AH-treated rats, indicative of improved nerve conduction. Histopathological examination revealed reduced perineural thickness in the sciatic nerve of AH-treated rats, suggesting less fibrosis. In motor function tests, AH-treated rats demonstrated enhanced performance, implying improved muscle strength and motor capacity. Conclusion: The findings indicate that AH treatment effectively reduces oxidative stress and inflammation in a rat model of diabetic neuropathy, leading to improved neuropathic symptoms. These results suggest that AH could be a promising therapeutic agent for managing DN, warranting further investigation for its potential clinical application.en_US
dc.description.versionPubLİsher's Versionen_US
dc.identifier.citationGönüllü, E., Dağıstan, G., Özsezer, Y., Erdoğan, M. A. & Erbaş, O. (2023). Aesculus hippocastanum alleviates diabetic neuropathy by reducing MMP-9 and MMP-10 levels. International Journal of Pharmacology, 19(7), 862-871. doi:10.3923/ijp.2023.862.871en_US
dc.identifier.endpage871
dc.identifier.issn1811-7775en_US
dc.identifier.issn1812-5700en_US
dc.identifier.issue7
dc.identifier.startpage862
dc.identifier.urihttps://hdl.handle.net/11729/5928
dc.identifier.urihttp://dx.doi.org/10.3923/ijp.2023.862.871
dc.identifier.volume19
dc.identifier.wosWOS:001178136500004en_US
dc.identifier.wosqualityQ4
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScience Citation Index Expanded (SCI-EXPANDED)en_US
dc.institutionauthorÖzsezer, Yakupen_US
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherAsian Network Scientific Information-ANSINETen_US
dc.relation.ispartofInternational Journal of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetic neuropathyen_US
dc.subjectAesculus hippocastanumen_US
dc.subjectMMP-9 and MMP-10en_US
dc.subjectOxidative stressen_US
dc.subjectAnti-inflammatory treatmenten_US
dc.subjectNeuropathy managementen_US
dc.subjectPeripheral neuropathyen_US
dc.subjectSystemen_US
dc.subjectNephropathyen_US
dc.subjectPrevalenceen_US
dc.subjectSeedsen_US
dc.subjectEscinen_US
dc.subjectAciden_US
dc.titleAesculus hippocastanum alleviates diabetic neuropathy by reducing MMP-9 and MMP-10 levelsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Aesculus_hippocastanum_alleviates_diabetic_neuropathy_by_reducing_MMP_9_and_MMP_10_levels.pdf
Boyut:
953 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Publisher's Version
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu | Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
WoS İndeksli Yayınlar Koleksiyonu