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Yayın Neuroimaging findings related to panic disorder: a brief review(Klinik Psikoloji Araştırmaları Derneği, 2022-12-26) Kazancı, Dilara; Saltoğlu, Seren; Erdoğdu, EmelPanic disorder (PD) is defined by recurrent unanticipated panic attacks and anxiety of losing control, which negatively affects the patients’ quality of life. Various neuroimaging techniques allow to assess brain structure or function and therefore represent important tools to understand the mechanisms related to PD pathology. Current studies have highlighted neural differences between PD patients and healthy controls using MRI, PET, SPECT, or EEG. However, there is an urgent need to discuss findings from various investigations simultaneously in order to obtain a multidimensional understanding of PD pathology, which further allows identifying possible target regions for more effective treatment or prevention strategies. Therefore, the present work briefly reviewed PD related neuroimaging studies published between 2012 and 2021. Relevant articles were searched using a combination of keywords relevant to various neuroimaging techniques (e.g., MRI, MRS, PET, EEG, fNIRS) and to PD (e.g., panic, anxiety, panic disorder). Studies involving patients with comorbid conditions other than agoraphobia and participants aged under 18 were excluded. A total of 20 studies fulfilling inclusion criteria were considered in this review. Most of the reviewed studies point to structural and functional neural changes in regions of the proposed fear network mostly including the hippocampi, thalamic nuclei, amygdala, anterior cingulate corti, insulae and other frontal lobe regions. Such neural changes in PD are thought to result in a hypersensitive fear network affecting normal emotional processing. Finally, studies showed that different treatments can partly reverse these changes, which significantly improves the quality of life in PD patients.Yayın Effects of early psychological trauma on limbic system structure and function(Psikiyatride Güncel Yaklaşımlar, 2024-12-25) Kılıç, Bengü Sare Sevda Pelin; Saltoğlu, Seren; Erdoğdu, EmelThis paper aims to review the subtypes of childhood trauma and its effects on brain structures and function, especially the hippocampus and amygdala within the limbic system, in the context of clinical psychology. For this purpose, original articles published between 1996 and 2024 were systematically searched in major databases such as PubMed, PsycArticles, Web of Science, and Google Scholar using keywords such as early childhood trauma, psychological trauma, limbic system, hippocampus, amygdala, and neuroimaging. The articles were initially screened based on their titles, and those meeting the search criteria, including study population, investigated brain regions, and types of traumas, were further assessed for relevance. Ultimately, 136 articles were selected and discussed in this review. Trauma experiences in early life can have a significantly negative influence on a person's psychological health by causing neurodevelopmental impairments, especially in the limbic system. While it is understood that trauma influences how individuals think, behave, and feel, the results of neuroimaging studies reveal variations in the amygdala and hippocampus based on different trauma subtypes. These changes merit deeper investigation in future research to fully understand the reasons behind the diverse findings in existing literature.
