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Yayın Electroencephalography signatures associated with developmental dyslexia identified using principal component analysis(Multidisciplinary Digital Publishing Institute (MDPI), 2025-08-27) Eroğlu, Günet; Harb, Mhd Raja AbouBackground/Objectives: Developmental dyslexia is characterised by neuropsychological processing deficits and marked hemispheric functional asymmetries. To uncover latent neurophysiological features linked to reading impairment, we applied dimensionality reduction and clustering techniques to high-density electroencephalographic (EEG) recordings. We further examined the functional relevance of these features to reading performance under standardised test conditions. Methods: EEG data were collected from 200 children (100 with dyslexia and 100 age- and IQ-matched typically developing controls). Principal Component Analysis (PCA) was applied to high-dimensional EEG spectral power datasets to extract latent neurophysiological components. Twelve principal components, collectively accounting for 84.2% of the variance, were retained. K-means clustering was performed on the PCA-derived components to classify participants. Group differences in spectral power were evaluated, and correlations between principal component scores and reading fluency, measured by the TILLS Reading Fluency Subtest, were computed. Results: K-means clustering trained on PCA-derived features achieved a classification accuracy of 89.5% (silhouette coefficient = 0.67). Dyslexic participants exhibited significantly higher right parietal–occipital alpha (P8) power compared to controls (mean = 3.77 ± 0.61 vs. 2.74 ± 0.56; p < 0.001). Within the dyslexic group, PC1 scores were strongly negatively correlated with reading fluency (r = −0.61, p < 0.001), underscoring the functional relevance of EEG-derived components to behavioural reading performance. Conclusions: PCA-derived EEG patterns can distinguish between dyslexic and typically developing children with high accuracy, revealing spectral power differences consistent with atypical hemispheric specialisation. These results suggest that EEG-derived neurophysiological features hold promise for early dyslexia screening. However, before EEG can be firmly established as a reliable molecular biomarker, further multimodal research integrating EEG with immunological, neurochemical, and genetic measures is warranted.Yayın Assessing ChatGPT's accuracy in dyslexia inquiry(Institute of Electrical and Electronics Engineers Inc., 2024) Eroğlu, Günet; Harb, Mhd Raja AbouDyslexia poses challenges in accessing reliable information, crucial for affected individuals and their families. Leveraging chatbot technology offers promise in this regard. This study evaluates the OpenAI Assistant's precision in addressing dyslexia-related inquiries. Three hundred questions commonly posed by parents were categorized and presented to the Assistant. Expert evaluation of responses, graded on accuracy and completeness, yielded consistently high scores (median=5). Descriptive questions scored higher (average=4.9568) than yes/no questions (average=4.8957), indicating potential response challenges. Statistical analysis highlighted the significance of question specificity in response quality. Despite occasional difficulties, the Assistant demonstrated adaptability and reliability in providing accurate dyslexia-related information.Yayın “Can we use a biomarker detection algorithm to measure the effectiveness of 14-channel neurofeedback in dyslexia?”(Routledge, 2025-10-01) Eroğlu, Günet; Harb, Raja AbouDyslexia, one of children’s most common neurological diversities, primarily manifests as a reduced reading ability. Genetic factors contribute to dyslexia, with contemporary theories attributing it to a delay in left hemispheric lateralization that reduces effective reading and writing skills. To assist dyslexic children, smartphone application, Auto Train Brain, has been developed to enhance reading comprehension and speed. Previously, the efficacy of the mobile application’s training program was assessed using psychometric tests; however, our study employed a biomarker detection software to evaluate the neurofeedback’s impact. Machine learning (ML) techniques have recently gained traction in differentiating between dyslexia and typically developing children (TDC). The dataset of this study consists of 100 sessions of 2-minute resting-state eyes-open 14-channel Quantitative Electroencephalography (QEEG) data from 100 children with dyslexia and 100 TDC. Therefore, the dyslexia biomarker detection software assessed the efficacy of the 14-channel neurofeedback administered via Auto Train Brain. Results showed significant improvement in electrophysiological normalization, increasing from 30% in the first 20 sessions to 61% by the end of the training. A two-proportion Z-test confirmed this improvement was statistically significant (Z = −3.96, p = 0.00007), particularly between the 1–20 and 1–60 session intervals (Z = −2.66, p = 0.0079).Yayın Electrophysiological signatures of developmental dyslexia: towards EEG-based biomarker identification and neurogenetic correlates(MDPI, 2025-06-30) Eroğlu, Günet; Harb, Mhd Raja AbouDyslexia is a neurodevelopmental disorder characterized by altered hemispheric specialization and disrupted phonological processing. In this study, we applied Principal Component Analysis (PCA) to high-dimensional electroencephalographic (EEG) recordings from 200 children (100 dyslexic, 100 controls) to extract latent neurophysiological features associated with reading impairment. Our findings revealed significant right-hemisphere dominance in dyslexic individuals, particularly in the P8 electrode within the alpha band, consistent with compensatory neural strategies. Despite the absence of clinical comorbidities or medication use, distinct clustering emerged, supporting the utility of PCA for early screening. Future directions include correlating EEG-derived features with known dyslexia-related gene expression profiles (e.g., DCDC2, KIAA0319), neurotransmitter imbalances, and neuroinflammatory markers. These integrative analyses may establish EEG signals as reliable, non-invasive biomarkers for molecular-level screening in developmental learning disorders.Yayın Theta and Beta1 frequency band values predict dyslexia classification(John Wiley and Sons Ltd, 2025-12-29) Eroğlu, Günet; Harb, Mhd Raja AbouDyslexia, impacting children's reading skills, prompts families to seek cost-effective neurofeedback therapy solutions. Utilising machine learning, we identified predictive factors for dyslexia classification. Employing advanced techniques, we gathered 14-channel Quantitative Electroencephalography (QEEG) data from 200 participants, achieving 99.6% dyslexic classification accuracy through cross-validation. During validation, 48% of dyslexic children's sessions were consistently classified as normal, with a 95% confidence interval of 47.31 to 48.68. Focusing on individuals consistently diagnosed with dyslexia during therapy, we found that dyslexic individuals exhibited higher theta values and lower beta1 values compared to typically developing children. This study pioneers machine learning in predicting dyslexia classification factors, offering valuable insights for families considering neurofeedback therapy investment.Yayın Secure and interpretable dyslexia detection using homomorphic encryption and SHAP-based explanations(Institute of Electrical and Electronics Engineers Inc., 2025-10-25) Harb, Mhd Raja Abou; Çeliktaş, Barış; Eroğlu, GünetProtecting sensitive healthcare data during machine learning inference is critical, particularly in cloud-based environments. This study addresses the privacy and interpretability challenges in dyslexia detection using Quantitative EEG (QEEG) data. We propose a privacy-preserving framework utilizing Homomorphic Encryption (HE) to securely perform inference with an Artificial Neural Network (ANN). Due to the incompatibility of non-linear activation functions with encrypted arithmetic, we employ a dedicated approximation strategy. To ensure model interpretability without compromising privacy, SHapley Additive exPlanations (SHAP) are computed homomorphically and decrypted client-side. Experimental evaluations demonstrate that the encrypted inference achieves an accuracy of 90.03% and an AUC of 0.8218, reflecting only minor performance degradation compared to plaintext inference. SHAP value comparisons (Spearman correlation = 0.59) validate the reliability of the encrypted explanations. These results confirm that integrating privacy-preserving and explainable AI approaches is feasible for secure, ethical, and compliant healthcare deployments.
