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Yayın Electroencephalography signatures associated with developmental dyslexia identified using principal component analysis(Multidisciplinary Digital Publishing Institute (MDPI), 2025-08-27) Eroğlu, Günet; Harb, Mhd Raja AbouBackground/Objectives: Developmental dyslexia is characterised by neuropsychological processing deficits and marked hemispheric functional asymmetries. To uncover latent neurophysiological features linked to reading impairment, we applied dimensionality reduction and clustering techniques to high-density electroencephalographic (EEG) recordings. We further examined the functional relevance of these features to reading performance under standardised test conditions. Methods: EEG data were collected from 200 children (100 with dyslexia and 100 age- and IQ-matched typically developing controls). Principal Component Analysis (PCA) was applied to high-dimensional EEG spectral power datasets to extract latent neurophysiological components. Twelve principal components, collectively accounting for 84.2% of the variance, were retained. K-means clustering was performed on the PCA-derived components to classify participants. Group differences in spectral power were evaluated, and correlations between principal component scores and reading fluency, measured by the TILLS Reading Fluency Subtest, were computed. Results: K-means clustering trained on PCA-derived features achieved a classification accuracy of 89.5% (silhouette coefficient = 0.67). Dyslexic participants exhibited significantly higher right parietal–occipital alpha (P8) power compared to controls (mean = 3.77 ± 0.61 vs. 2.74 ± 0.56; p < 0.001). Within the dyslexic group, PC1 scores were strongly negatively correlated with reading fluency (r = −0.61, p < 0.001), underscoring the functional relevance of EEG-derived components to behavioural reading performance. Conclusions: PCA-derived EEG patterns can distinguish between dyslexic and typically developing children with high accuracy, revealing spectral power differences consistent with atypical hemispheric specialisation. These results suggest that EEG-derived neurophysiological features hold promise for early dyslexia screening. However, before EEG can be firmly established as a reliable molecular biomarker, further multimodal research integrating EEG with immunological, neurochemical, and genetic measures is warranted.Yayın ANN activation function estimators for homomorphic encrypted inference(Institute of Electrical and Electronics Engineers Inc., 2025-06-13) Harb, Mhd Raja Abou; Çeliktaş, BarışHomomorphic Encryption (HE) enables secure computations on encrypted data, facilitating machine learning inference in sensitive environments such as healthcare and finance. However, efficiently handling non-linear activation functions, specifically Sigmoid and Tanh, remains a significant computational challenge for encrypted inference using Artificial Neural Networks (ANNs). This study introduces a lightweight, ANN-based estimator designed to accurately approximate activation functions under homomorphic encryption. Unlike traditional polynomial and piecewise linear approximations, the proposed ANN estimators achieve superior accuracy with lower computational overhead associated with bootstrapping or high-degree polynomial techniques. These estimators are trained on plaintext data and seamlessly integrated into encrypted inference pipelines, significantly outperforming conventional methods. Experimental evaluations demonstrate notable improvements, with ANN estimators enhancing accuracy by approximately 2% for Sigmoid and up to 73% for Tanh functions, improving F1-scores by approximately 2% for Sigmoid and up to 88% for Tanh, and markedly reducing Mean Square Error (MSE) by up to 96% compared to polynomial approximations. The ANN estimator achieves an accuracy of 97.70% and an AUC of 0.9997 when integrated into a CNN architecture on the MNIST dataset, and an accuracy of 85.25% with an AUC of 0.9459 on the UCI Heart Disease dataset during ciphertext inference. These results underscore the estimator’s practical effectiveness and computational feasibility, making it suitable for secure and efficient ANN inference in encrypted environments.Yayın Electrophysiological signatures of developmental dyslexia: towards EEG-based biomarker identification and neurogenetic correlates(MDPI, 2025-06-30) Eroğlu, Günet; Harb, Mhd Raja AbouDyslexia is a neurodevelopmental disorder characterized by altered hemispheric specialization and disrupted phonological processing. In this study, we applied Principal Component Analysis (PCA) to high-dimensional electroencephalographic (EEG) recordings from 200 children (100 dyslexic, 100 controls) to extract latent neurophysiological features associated with reading impairment. Our findings revealed significant right-hemisphere dominance in dyslexic individuals, particularly in the P8 electrode within the alpha band, consistent with compensatory neural strategies. Despite the absence of clinical comorbidities or medication use, distinct clustering emerged, supporting the utility of PCA for early screening. Future directions include correlating EEG-derived features with known dyslexia-related gene expression profiles (e.g., DCDC2, KIAA0319), neurotransmitter imbalances, and neuroinflammatory markers. These integrative analyses may establish EEG signals as reliable, non-invasive biomarkers for molecular-level screening in developmental learning disorders.
