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2024 - 20252
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Yazar: Işıkçı Koca, Elif ×

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  • Küçük Resim
    Yayın
    Eco-friendly bacterial cellulose/castor oil hydrogels: physicochemical behavior and biocompatibility
    (Sakarya University, 2025-10-27) Işıkçı Koca, Elif; Pınar, Orkun; Yalçın Çapan, Özlem; Çaylı, Gökhan; Kazan, Dilek; Çakır Hatır, Pınar
    In the present work, novel thermoresponsive hydrogels were developed from renewable resources, and the influence of bacterial cellulose molar ratio on their chemical structure, thermal properties, swelling behavior, morphology, and biocompatibility was systematically investigated. The hydrogels were fabricated using castor oil, 4,4'-diphenylmethane diisocyanate, bacterial cellulose, Nisopropylacrylamide, and N,N'-Methylenebisacrylamide. Structural and physicochemical characterizations were performed by Fourier-transform infrared spectroscopy, scanning electron microscopy, differential scanning calorimetry, and thermogravimetric analysis. The highest equilibrated swelling degree was achieved as 592.6% at the maximum bacterial cellulose content. SEM images revealed that the formation of spongy architecture is caused by the increase in the bacterial cellulose content. In vitro biocompatibility studies revealed that the hydrogel with the highest bacterial cellulose content exhibited the greatest cytocompatibility, with an IC50 value of 11.16 mg/ml. Overall, the findings demonstrate the successful fabrication of a novel bio-based thermoresponsive hydrogel through an eco-friendly approach, highlighting its potential for diverse biomedical applications.
  • Küçük Resim
    Yayın
    Heart rate variability in athletes during a virtual reality-based working memory experience
    (Altınbaş University, 2024-12-31) Özgün, İrem; Işıkçı Koca, Elif; Scharfen, Hansi; Özbilgen, Eda; Yerlikaya, Deniz; Duru, Adil Deniz
    The study explores the link between cognitive performance and heart rate variability (HRV) using a virtual reality (VR) cognitive assessment system by Neo Auvra® Digital Health and Bionics Technologies Inc. All participants underwent varying levels of mental workload in the VR environment, with metrics like Verbal Working Memory Capacity Item Number (VeWMCIN), Visuospatial Working Memory Capacity Item Number (ViWMCIN), Working Memory Efficiency Task Switching Speed (WMETSS), and Visual Attention Accuracy (VAA). Heart Rate Variability (HRV) data was collected during VR session from two groups: athletes and sedentary individuals. Multivariate analysis of variance (MANOVA) was employed. When analyzing the results of the study, it was concluded that HRV parameters did not differ significantly (according to p-value) or significantly (according to 95% Cis and effect sizes) between different levels (cognitive load), HRV parameters showed significant (according to p-value) and significant (according to 95% Cis and effect sizes) differences between different groups, while athletes had better values in all HRV parameters except HF%, LF%, IF%.