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Yayın Integrated ultrasonic imaging systems based on CMUT arrays: Recent progress(IEEE, 2004) Wygant, Ira O.; Zhuang, Xuefeng; Yeh, David T.; Nikoozadeh, Amin; Oralkan, Ömer; Ergün, Arif Sanlı; Karaman, Mustafa; Khuri-Yakub, Butrus ThomasThis paper describes the development of an ultrasonic imaging system based on a two-dimensional capacitive micromachined ultrasonic transducer (CMUT) array. The transducer array and front-end electronics are designed to fit in a 5-mm endoscopic channel. A custom-designed integrated circuit, which comprises the front-end electronics, will be connected with the transducer elements via through-wafer interconnects and flip-chip bonding. FPGA-based signal-processing hardware will provide real-time three-dimensional imaging. The imaging system is being developed to demonstrate a means of integrating the front-end electronics with the transducer array and to provide a clinically useful technology. Integration of the electronics can improve signal-to-noise ratio, reduce the number of cables connecting the imaging probe to a separate processing unit, and provide a means of connecting electronics to large two-dimensional transducer arrays. This paper describes the imaging system architecture and the progress we have made on implementing each of its components: a 16×16 CMUT array, custom-designed integrated circuits, a flip-chip bonding technique, and signal-processing hardware.Yayın Volumetric ultrasound imaging using 2-D CMUT arrays(IEEE-Inst Electrical Electronics Engineers Inc, 2003-11) Oralkan, Ömer; Ergün, Arif Sanlı; Cheng, Ching-Hsiang; Johnson, Jeremy A.; Karaman, Mustafa; H. Lee, Thomas; Khuri-Yakub, Butrus ThomasRecently, capacitive micromachined ultrasonic transducers (CMUTs) have emerged as a candidate to overcome the difficulties in the realization of 2-D arrays for real-time 3-D imaging. In this paper, we present the first volumetric images obtained using a 2-D CMUT array. We have fabricated a 128 x 128-element 2-D CMUT array with through-wafer via interconnects and a 420-mum element pitch. As an experimental prototype, a 32 x 64-element portion of the 128 X 128-element array was diced and flip-chip bonded onto a glass fanout chip. This chip provides individual leads from a central 16 X 16-element portion of the array to surrounding bondpads. An 8 x 16-element poition of the array was used in the experiments along with a 128-channel data acquisition system. For imaging phantoms, we used a 2.37-mm diameter steel sphere located 10 mm from the array center and two 12-mm-thick Plexiglas plates located 20 mm and 60 mm from the array. A 4 X 4 group of elements in the middle of the 8 X 16-element array was used in transmit, and the remaining elements were used to receive the echo signals. The echo signal obtained from the spherical target presented a frequency spectrum centered at 4.37 MHz with a 100% fractional bandwidth, whereas the frequency spectrum for the echo signal from the parallel plate phantom was centered at 3.44 MHz with a 91% fractional bandwidth. The images were reconstructed by using RF beamforming and synthetic phased array approaches and visualized by surface rendering and multiplanar slicing techniques. The image of the spherical target has been used to approximate the point spread function of the system and is compared with theoretical expectations. This study experimentally demonstrates that 2-D CMUT arrays can be fabricated with high yield using silicon IC-fabrication processes, individual electrical connections can be provided using through-wafer vias, and flip-chip bonding can be used to integrate these dense 2-D arrays with electronic circuits for practical 3-D imaging applications.Yayın CMUT-based volumetric ultrasonic imaging array design for forward looking ICE and IVUS applications(SPIE-Int Soc Optical Engineering, 2013) Tekeş, Coşkun; Zahorian, Jaime S.; Xu, Toby; Rashid, Muhammad Wasequr; Satır, Sarp; Gürün, Gökçe; Karaman, Mustafa; Hasler, Jennifer Olson; Değertekin, Fahrettin LeventDesigning a mechanically flexible catheter based volumetric ultrasonic imaging device for intravascular and intracardiac imaging is challenging due to small transducer area and limited number of cables. With a few parallel channels, synthetic phased array processing is necessary to acquire data from a large number of transducer elements. This increases the data collection time and hence reduces frame rate and causes artifacts due to tissue-transducer motion. Some of these drawbacks can be resolved by different array designs offered by CMUT-on-CMOS approach. We recently implemented a 2.1-mm diameter single chip 10 MHz dual ring CMUT-on-CMOS array for forward looking ICE with 64-transmit and 56-receive elements along with associated electronics. These volumetric arrays have the small element size required by high operating frequencies and achieve sub mm resolution, but the system would be susceptible to motion artifacts. To enable real time imaging with high SNR, we designed novel arrays consisting of multiple defocused annular rings for transmit aperture and a single ring receive array. The annular transmit rings are utilized to act as a high power element by focusing to a virtual ring shaped line behind the aperture. In this case, image reconstruction is performed by only receive beamforming, reducing total required firing steps from 896 to 14 with a trade-off in image resolution. The SNR of system is improved more than 5 dB for the same frequency and frame rate as compared to the dual ring array, which can be utilized to achieve the same resolution by increasing the operating frequency.Yayın Damar içi öne bakan ultrasonik görüntüleme için eşdeğer dizi örnekleme yöntemleri(IEEE, 2009-06-26) Tekeş, Coşkun; Karaman, MustafaDamar içi öne bakan ultrasonik görüntüleme gerçek zamanlı hacimsel (üç boyutlu) görüntülemeye imkan vermesi bakımından yaygın olarak kullanılmaktadır. Damar içi görüntülemede fiziksel boyutların küçük olması nedeniyle alıcı-verici kanal sayısı çok sınırlanmakta ve dolayısıyla yapay evreli dizi teknikleri kullanılmaktadır. Öte yandan, harekete bağlı görüntü bozukluklarını azaltmak için işaret gönderme alma adım sayısının azaltılması gerekmektedir. Bu, eşdeğer dizideki fazlalık frekans bileşenleri azaltılarak sağlanabilir. Bu çalışmada, eşdeğer dizideki fazlalık frekans bileşenlerinin azaltılmasına dayalı farklı örnekleme teknikleri incelenmiştir. Bu tekniklerin görüntü kalitesi 64 elemanlı bir halkasal dizinin asıl ve kontrol eşdeğer dizileri referans alınarak karşılaştırmalı olarak irdelenmiştir. Benzetim sonuçları 64 elemanlı bir halka dizi için 2049 asıl küme, 350 azaltılmış küme 40 dB içinde eşdeğer performans vermektedir.Yayın Coherent array imaging using phased subarrays. Part II: Simulations and experimental results(IEEE-INST Electrical Electronics Engineers Inc, 2005-01) Johnson, Jeremy A.; Oralkan, Ömer; Ergün, Arif Sanlı; Demirci, Utkan; Karaman, Mustafa; Khuri-Yakub, Butrus ThomasThe basic principles and theory of phased subarray (PSA) imaging imaging provides the flexibility of reducing I he number of front-end hardware channels between that of classical synthetic aperture (CSA) imaging-which uses only one element per firing event-and full-phased array (FPA,) imaging-which uses all elements for each firing. The performance of PSA generally ranges between that obtained by CSA and FPA using the same array, and depends on the amount of hardware complexity reduction. For the work described in this paper, we performed FPA, CSA, and PSA imaging of a resolution phantom using both simulated and experimental data from a 3-MHz, 3.2-cm, 128-element capacitive micromachined ultrasound transducer (CMUT) array. The simulated system point responses in the spatial and frequency domains are presented as a means of studying the effects of signal bandwidth, reconstruction filter size, and subsampling rate on the PSA system performance. The PSA and FPA sector-scanned images were reconstructed using the wideband experimental data with 80% fractional bandwidth, with seven 32-element subarrays used for PSA imaging. The measurements on the experimental sector images indicate that, at the transmit focal zone, the PSA method provides a 10% improvement in the 6-dB lateral resolution, and the axial point resolution of PSA imaging is identical to that of FPA imaging. The signal-to-noise ratio (SNR) of PSA image was 58.3 dB, 4.9 dB below that of the FPA image, and the contrast-to-noise ratio (CNR) is reduced by 10%. The simulated and experimental test results presented in this paper validate theoretical expectations and illustrate the flexibility of PSA imaging as a way to exchange SNR and frame rate for simplified front-end hardware.Yayın Minimally redundant 2-D array designs for 3-D medical ultrasound imaging(IEEE-Inst Electrical Electronics Engineers Inc, 2009-07) Karaman, Mustafa; Wygant, Ira O.; Oralkan, Ömer; Khuri-Yakub, Butrus ThomasIn real-time ultrasonic 3-D imaging, in addition to difficulties in fabricating and interconnecting 2-D transducer arrays with hundreds of elements, there are also challenges in acquiring and processing data from a large number of ultrasound channels. The coarray (spatial convolution of the transmit and receive arrays) can be used to find efficient array designs that capture all of the spatial frequency content (a transmit-receive element combination corresponds to a spatial frequency) with a reduced number of active channels and firing events. Eliminating the redundancies in the transmit-receive element combinations and firing events reduces the overall system complexity and improves the frame rate. Here we explore four reduced redundancy 2-D array configurations for miniature 3-D ultrasonic imaging systems. Our approach is based on 1) coarray design with reduced redundancy using different subsets of linear arrays constituting the 2-D transducer array, and 2) 3-D scanning using fan-beams (narrow in one dimension and broad in the other dimension) generated by the transmit linear arrays. We form the overall array response through coherent summation of the individual responses of each transmit-receive array pairs. We present theoretical and simulated point spread functions of the array configurations along with quantitative comparison in terms of the front-end complexity and image quality.Yayın Thermoacoustic image reconstruction based on layered tissue model(SPIE-Int Soc Optical Engineering, 2017) Bayıntır, Hazel; İdemen, Mehmet Mithat; Ünalmış Uzun, Banu; Karaman, Mustafa; Elmas, DemetWe derived analytical forward and inverse solution of thermoacoustic wave equation for inhomogeneous multi layered planar and cylindrical mediums with the source distribution existing in all layers. These solutions are applicable for imaging of organs such as breast and brain, whose structures are suitable for multi-layer modelling. For qualitative testing and comparison of the point-spread-functions associated with the homogeneous and layered solutions, we performed numerical simulations. Our simulation results show that the conventional inverse solution based on homogeneous medium assumption, as expected, produces incorrect locations of point sources and significantly increased side lobes, whereas our inverse solution involving the multi-layered medium produces point sources at the correct locations with lower side lobes.Yayın Cross-sectional thermoacoustic imaging using multi-layer cylindrical media(IEEE, 2017-11-10) Elmas, Demet; Ünalmış Uzun, Banu; İdemen, Mehmet Mithat; Karaman, MustafaFor cross-sectional two-dimensional thermoacustic imaging of breast and brain, we explored solution of the wave equation using layered tissue model consisting of concentric annular layers on a cylindrical cross-section. To obtain the forward and inverse solutions of the thermoacoustic wave equation, we derived the Green's function involving Bessel and Hankel functions by employing the geometrical and acoustic parameters (densities and velocities) of layered media together with temporal initial condition, radiation conditions and continuity conditions on the layers' boundaries. The image reconstruction based on this approach involves the layer parameters as the apriori information which can be estimated from the acquired thermoacoustic data. To test and compare our layered solution with conventional solution based on homogeneous medium assumption, we performed simulations using numerical test phantoms consisting of sources distributed in the layered structure.Yayın Çok katmanlı silindirik yapılar için termoakustik dalga denkleminin ters çözümü(IEEE, 2017-06-27) Elmas, Demet; Ünalmış Uzun, Banu; İdemen, Mehmet Mithat; Karaman, MustafaTermoakustik görüntüleme, elektromanyetik enerji uyarımı ile ultrason dalgaları oluşumunu sağlayan yeni bir yöntemdir. Bu sistemin görüntüleme işlemi termoakustik dalga denkleminin ters çözümüne dayanmaktadır. Ters çözümde görüntülenecek dokunun homojen yapıda olduğu varsayımı, görüntü kalitesinin azalmasına neden olur. Bu çalışmada, meme ve beyinin görüntülemesinde uygulanabilecek üç boyutlu eş merkezli silindirik çok katmanlı yapılar için termoakustik dalga denkleminin analitik ters çözümü elde edilmiştir. Çözümü sayısal olarak test etmek için, noktasal kaynaklar içeren üç katmanlı fantom kullanılarak numerik simulasyonlar elde edilmiştir.
