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  • Yayın
    Neuropsychiatric outcomes and caregiver distress in primary progressive aphasia
    (Wiley, 2023-01) Seçkin, Mustafa; Yıldırım, Elif; Demir, İlayda; Orhun, Ömer; Bülbül, Ezgi; Velioğlu, H. Aziz; Öget, Öktem; Yeşilot, Nilüfer; Çoban, Oğuzhan; Gürvit, Hakan
    Background: In this study, we aimed to outline the neuropsychiatric consequences of primary progressive aphasia (PPA) and to understand how neuropsychiatric symptomatology affects distress in caregivers. Methods: The Neuropsychiatric Inventory (NPI) including the distress index (NPI-Distress) was used. Additional information about the caregiver burden was obtained using Zarit Burden Interview (ZBI). NPI, NPI-Distress, and ZBI data from 17 patients with a clinical diagnosis of PPA were compared with 10 stroke aphasia patients. Neuropsychiatric symptomatology was investigated based on three clusters; Mood, Frontal/Comportmental, and Psychotic/Disruptive. Additionally, the Activities of Daily Living Questionnaire (ADLQ) was used to outline the functional impairment. Twelve healthy controls were included to compare the neurocognitive test scores with PPA and stroke aphasia groups. Results: A greater number of neuropsychiatric symptoms were observed in the PPA group compared to the stroke aphasia group. The number of symptoms in Mood, and Frontal/Comportmental clusters were greater than the number of symptoms in Psychotic/Disruptive clusters in the PPA group, whereas no significant relationship between the number of symptoms and symptom clusters was found in the stroke aphasia group. In the PPA group, a strong correlation was found between the NPI-Frequency × Severity scores and the NPI-Distress scores. Moreover, the NPI-Distress scores in the PPA group strongly correlated with the ZBI scores. Scores for anxiety, irritability/lability, and apathy had a stronger correlation with the NPI-Distress scores compared to the other NPI symptoms. The Communication subscale was the most impaired domain in the PPA group. Travel, and Employment and Recreation subscales showed greater functional impairment in the stroke aphasia group compared to the PPA group. Conclusions: Neuropsychiatric symptoms in PPA in our study were more frequent than previously reported. Furthermore, the distress index of the NPI was not only correlated with the severity of the neuropsychiatric symptoms but also reflected the overall burden on the caregivers in the PPA group.
  • Yayın
    Measurement of perceived psychological safety: integration, review and evidences for the scale in the context of Turkiye
    (İstanbul Üniversitesi Yayınevi, 2022-06-22) Bülbül, Seçil; İşiaçık, Serin; Aytaç, Serpil
    Psychological safety can predict many positive individual and organizational outcomes at work, and previous research addressed how psychological safety contributes to positive work attitudes and behaviors. In Turkey, there is quite an amount of research showing the contributing role of psychological safety perception on employees' positive performance behaviors and organizational effectiveness and innovativeness. However, previous research in Turkey does not adequately show the reliability and validity of the psychological safety scale, which was developed by Edmondson (1999). Based on the suggested requirement this study aimed to investigate the psychological safety perceptions of individuals who work in various sectors in Turkey. The adapted version of the psychological safety scale was used to gain evidence for the reliability and validity of the instrument in Turkey. In total, 585 individuals working in various industries and from various occupational groups participated in the research. Both exploratory factor analysis and the confirmatory factor analysis showed that Turkish adapted version of the psychological safety scale was valid and reliable.
  • Yayın
    Dijital nöropsikoloji: yaşlı bireylerin bilişsel işlevlerinin değerlendirilmesinde kullanılan teknolojik yaklaşımlar
    (İ.Ü. EDEBİYAT FAKÜLTESİ, 2022-04-12) Yıldırım, Elif
    Nüfusun yaşlanması ile paralel olarak demans tanılı kişilerin sayısı artmaktadır. Demans seyrinin iyileştirilmesi için kritik bir öneme sahip olan bilişsel bozuklukların erken saptanmasında nöropsikolojik değerlendirmenin büyük bir rolü olduğu kabul edilmektedir. Sıklıkla klasik kâğıt- kalem testleri ile uygulanan nöropsikolojik değerlendirme, günümüzde gelişen teknoloji ile birlikte dijitalleşmeye başlamıştır. Özellikle de Covid–19 pandemisi ile birlikle bu dijitalleşme ivme kazanmıştır. Bu çalışmada, yaşlı bireylerin nöropsikolojik değerlendirmelerinde kullanılan dijital yaklaşımların incelenmesi amaçlanmaktadır. Bu kapsamda, telenöropsikoloji, bilgisayarlı nöropsikolojik değerlendirme bataryaları, mobil teknoloji ya da web temelli değerlendirme araçları ve sanal gerçeklik, arttırılmış gerçeklik gibi yenilikçi teknolojik yöntemlere dayanan ölçümleri içeren dijital yaklaşımların eleştirel bir değerlendirmesi yapılmıştır. Sıklıkla videokonferans aracılığı ile nöropsikolojik testlerin uzaktan uygulanmasına odaklanan telenöropsikoloji çalışmaları ile ilgili sonuçlar bu yöntemin güvenilir ve geçerli olduğunu belirtmektedir. Bilgisayarlı bataryalar ve mobil teknolojiye dayanan yöntemler, klinik dışı bireysel uygulamaya olanak sağlamakta ve geniş örneklemli takip çalışmaları için altyapı hazırlamaktadır. Sanal gerçeklik gibi yeni teknolojilerin kullanıldığı değerlendirme yöntemler ise henüz emekleme aşamasında olsa da daha hassas ölçümlerin yapılması için büyük potansiyel taşımaktadır. Ulaşılabilirliğin artması ve ölçümlerin standartlaşması gibi avantajlar taşıyan dijital yaklaşımlar içinde sıklıkla kullanılan yöntemlerin büyük bir kısmının klasik kağıt-kalem testleri ve hastaların tanıları ile tutarlı olduğu gösterilmiştir. Fakat dijital yaklaşımların detaylı psikometrik analizlerinin yapılması ve iyi uygulama rehberlerinin geliştirmesi konusunda çeşitli eksiklikler bulunmaktadır. Buna ek olarak, dijital yaklaşımların uzman-hasta ilişkisinde zorluk yaratabileceği ve hastanın test sırasında gözlemlenmesi konusunda kısıtlılıklar taşıdığı belirtilmektedir. Her ne kadar dijital nöropsikoloji uygulamalarının yarattığı kısıtlılıklar mevcut olsa da, dijital yaklaşımlar hastalar, alandaki uzmanlar ve sağlık sistemi açısından önemli faydalar sağlama potansiyeline sahiptir. Bu nedenle, tüm taraflar açısından fayda sağlayacak akademik ve klinik çalışmaların yapılması önem taşımaktadır.
  • Yayın
    Son ergenlik döneminde dissosiyatif bulgular ile ruminasyon arasındaki ilişkide duyguları ifade etmenin rolü
    (Kıbrıs Ruh Sağlığı Enstitüsü, 2023-03-27) Özgönül, Afranur; Aktan, Zekeriya Deniz; Ülkümen, İpek
    Bu araştırmanın temel amacı son ergenlik dönemindeki bireylerin dissosiyatif bulguları ile ruminasyon düzeyleri arasındaki ilişkide duyguları ifade etmenin aracı rolünü incelemektir. Araştırmaya 18-24 yasları arasında olan 502 kişi katılmıştır. Veriler, Sosyodemografik Bilgi Formu, Dissosiyasyon Ölçeği (DIS-Q), Ruminatif Düşünce Biçimi Ölçeği (RDBÖ) ve Duyguları İfade Etme Ölçeği (DİEÖ) aracılığıyla toplanmıştır. Araştırmadan elde edilen bulgulara göre son ergenlik dönemindeki bireylerin ruminasyon düzeyleri arttıkça duyguları ifade etme düzeylerinin azaldığı ve dissosiyasyon düzeylerinin arttığı; duyguları ifade etme düzeyleri azaldıkça dissosiyasyon düzeylerinin arttığı görülmüştür. Son ergenlik dönemindeki bireylerin dissosiyatif bulguları ile ruminasyon düzeyleri arasındaki ilişkide duyguları ifade etmenin kısmi aracı etkisi olduğu saptanmıştır. Araştırmamızın söz konusu değişkenlerin geçmiş araştırmalarda sınırlı sayıda incelenmesi açısından literatüre katkı sağladığı düşünülmektedir.
  • Yayın
    Evaluation of post-swallow residue with visual analysis of swallowing efficiency and safety in patients with idiopathic Parkinson's disease
    (Sage Publications Inc, 2023-12) Doruk, Can; Çaytemel, Berkay; Şahin, Erdi; Kara, Hakan; Samancı, Bedia; Abay, Sevinç Nisa; Bilgiç, Başar; Hanağası, Haşmet; Başaran, Bora; Enver, Necati; Rameau, Anais
    Objectives: Dysphagia is common in idiopathic Parkinson's disease (IPD) and is associated with impairments in both swallowing safety and swallowing efficiency. The goals of this study were to define post-swallow residue patterns in people with IPD and describe pathophysiological endoscopic findings affecting residue accumulation. Methods: This was a prospective single-blinded cross-sectional cohort study of patients with the diagnosis of IPD recruited from a Movement Disorder Clinic. Clinical variables included patient age, cognitive function, and measures of disease severity, and laryngoscopic examinations with a flexible endoscopic evaluation of swallowing (FEES) were completed for each patient. Visual Analysis of Swallowing Efficiency and Safety (VASES) was used to analyze FEES. Post-swallow residue outcomes and non-residue endoscopic outcomes including the Bowing index, Penetration Aspiration Scale (PAS) score, premature leakage, and build-up phenomenon were evaluated. Multiple regression models were used to evaluate factors affecting the residue at different anatomic levels. Results: Overall 53 patients completed the study. The multiple regression analyses showed a relation between (1) the presence of residue at the level of oropharynx and epiglottis with premature leakage, (2) the presence of residue at the level of the laryngeal vestibule and vocal folds with build-up phenomenon, and (3) the presence of residue at the level of the hypopharynx, laryngeal vestibule, and subglottis with airway invasion. Conclusion: Residue pattern during FEES is associated with specific swallow dysfunctions in IPD. Using residue localization and quantification may be a helpful tool in assessing the impact of targeted swallowing interventions in patients with IPD and dysphagia.
  • Yayın
    Mindfulness in the relationship between perceived stress and quality of life in pediatric asthma
    (İstanbul Üniversitesi, 2023-03-27) Ayhan, Ayşe Sena; Aktan, Zekeriya Deniz; Ülker Tamay, Zeynep
    Objective: The purpose of this study is to analyze the possible mediatör effect of mindfulness in the relationship between perceived stress and quality of life in pediatric asthma. Material and Method: The sample of this study consisted of 100 asthmatic children aged between 9-12 years who applied to the outpatient clinic of Istanbul University, Istanbul Faculty of Medicine, Division of Pediatric Allergy. Sociodemographic information forms, Perceived Stress Scale in Children (8-11 years), Child and Adolescent Mindfulness Measure (CAMM), and Pediatric Asthma Quality of Life Questionnaire (PAQLQ) were used as data collection tools. Linear hierarchical regression analysis was used during the process of analyzing data. Results: It has been identified that mindfulness has a partial mediatör effect on the relationship between perceived stress and quality of life (p = 0.000). The presence of a partial mediator effect of mindfulness has been determined in the relationship between perceived stress and symptoms which is the subscale of quality of life (p = 0.000). Finally, it has been demonstrated that mindfulness has a partial mediator effect on the relationship between perceived stress and emotional function which is another subscale of quality of life (p = 0.000). The mediating role of mindfulness in the relationship between perceived stress and activity limitations could not be analyzed due to the lack of a significant correlation between activity limitations which is the subscale of quality of life and mindfulness (p=0.178). Conclusion: It can be helpful to add psychotherapy interventions involving mindfulness practices to asthma treatment for better control of the disease in children.
  • Yayın
    The relationships of neuropsychological factors and loneliness preference in children with attention deficit hyperactivity disorder and cognitive disengagement syndrome
    (Routledge Journals, Taylor & Francis Ltd, 2025-04-03) İzmir, Sevim Berrin İnci; Aktan, Zekeriya Deniz; Ercan, Eyüp Sabri
    This study aimed to examine emotion dysregulation and internalizing disorders mediating the relationship between selective and sustained attention and loneliness preference in children diagnosed with attention deficit hyperactivity disorder (ADHD) and Cognitive Disengagement Syndrome (CDS). This study included 176 children and adolescents between ages 8 and 12. The solitude scale for children, Difficulties in Emotion Regulation Scale, Child Behavior Checklist, Barkley Sluggish Cognitive Tempo Scale, and CNS Vital Signs test were used. The results suggest that difficulties in emotion regulation and having an internalizing disorder had a mediating effect between difficulties in selective attention and preference for the loneliness of children with ADHD + CDS. Also, it was likely that the association between sustained attention and preference for loneliness is mediated by internalizing disorders. The results suggest that the social problems commonly exhibited by children with ADHD + CDS may be related to deficits in sustained and selective attention.
  • Yayın
    Healthy lifestyle behaviors of university students: the role of sense of coherence and family health climate
    (Dokuz Eylul University, 2025-01-31) Cerrahoğlu, Ece; Ünver, Buket; Ülkümen, İpek
    Purpose: This study aims to examine the predictive role of individual sense of coherence, family sense of coherence and family health climate variables on university students' healthy lifestyle behaviors. Material and Methods: The sample of the study consisted of 371 university students aged 18-25. Sociodemographic Information Form, Healthy Lifestyle Behaviors Scale, Sense of Coherence Scale, Family Sense of Coherence Scale, Family Health Climate Scale were applied to the participants in order to collect the research data. Correlation analysis, independent two-sample t-test, one-way ANOVA test and multiple linear regression analysis were used to analyze the data. Results: According to the results of correlation analysis, a positive relationship was found between healthy lifestyle behaviors and individual sense of coherence, family sense of coherence and family health climate (p<.05). As a result of the multiple linear hierarchical regression analysis, after controlling for the sex variable, individual sense of coherence and family health climate variables significantly predicted healthy lifestyle behaviors (p<.05), while family sense of coherence had no significant predictive role on healthy lifestyle behaviors (p>.05). Conclusion: The findings show that individual sense of coherence, family sense of coherence and family health climate variables are essential on university students' healthy lifestyle behaviors. The sense of coherence provides significant protection in adopting health behaviors that will determine future health and well-being. Similarly, increasing healthy living practices within the family is of great importance for young people to adopt healthy lifestyle behaviors.
  • Yayın
    Effects of o-tDCS and tDCS on maximal grip strength
    (Istanbul University Press, 2024-10-14) Şeker, Sercan; Eskicioğlu, Gaye; Küçük, Zeynep; Karamürsel, Sacit
    Objective: The aim of the current study was to examine and compare the effects of oscillatory transcranial direct current stimulation (o-tDCS) and transcranial direct current stimulation (tDCS) against sham stimulation on maximal intermittent gripping performance. Materials and Methods: The study included 25 healthy, right-handed male subjects (age range 18-35 years) who were randomly assigned to three separate groups: o-tDCS (n=9), tDCS (n=8) and sham (n=8). The left primary motor cortex was selected as the anodal stimulation region, and a cathode electrode was placed over the right supraorbital area. A hand dynamometer is used to measure the maximum grip values during a maximal intermittent gripping task. Between-group comparisons were made; for each stimulation group, baseline grip values of the participants were compared with those obtained during stimulation. Results: Although the o-tDCS group showed slightly better improvements in maximal and mean strength, there were no statistically significant differences between stimulation groups (p>0.05). Conclusion: The findings of the study suggest neither o-tDCS nor tDCS has a significant facilitative impact on grip strength values in healthy young males, most likely due to a ceiling effect in this population.
  • Yayın
    Turkish validity and reliability study of the childhood illness attitude scale
    (Routledge, 2025-03) Aktan, Zekeriya Deniz; İnci İzmir, Sevim Berrin; Ünlü, Beyza; Yılmaz Kahraman, İpek Su
    Severe forms of health anxiety cause serious dysfunction in people’s lives. Childhood Illness Attitude Scales (CIAS) is an assessment tool used to evaluate childhood health anxiety yet has not been validated for use in Turkey. The study aimed to examine the psychometric properties and factor structure of the Turkish version of the CIAS (CIAS-TR). The scale was administered to 306 children aged between 8 and 15 years. In addition to the CIAS-TR, participants were asked to complete the Screen for Child Anxiety-Related Emotional Disorders (SCARED) and the Pediatric Quality of Life Inventory (PedsQL). To measure test-retest reliability, CIAS-TR was completed by participants 15 days later. Results demonstrated good psychometric properties with high internal consistency and test-retest reliability. A positive correlation with SCARED and a negative correlation with PedsQL. Results from Confirmatory Factor Analysis suggested that a four-factor model best fit the data. The findings of the study indicate that the Turkish adaptation of the CIAS is an appropriate tool for assessing health anxiety in children.