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Yayın Effects of childhood trauma and clinical features on determining quality of life in patients with bipolar I disorder(Elsevier Science BV, 2014-06-20) Erten, Evrim; Funda Uney, Aslı; Saatçioğlu, İbrahim Ömer; Özdemir, Armağan; Fıstıkçı, Nurhan; Çakmak, DuranBackground: We explored how childhood trauma (CHT) affects the clinical expression of disorder and quality of life in patients with bipolar I (BP I) disorder.Methods: Euthymic patients (n=116) who subsequently received a diagnosis of BP-I disorder were consecutively included and were interviewed using the following sociodemographic and clinical data forms; Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HDRS), Childhood Abuse and Neglect Questionnaire (CANQ) and the 36 item Medical Outcome Study Short Form Health Survey (SF 36) The quality of life of BP-I patients with and without a history of CHT were examined.Results: The percentage of trauma was 61.2%. Patients who had CHT had higher frequencies of depressive episodes (t = -2.38, p=0.019), total episodes (t = -2.25, p=0.026), attempted suicide more often (chi(2)=18.12, p=0.003) and had lower scores on the pain subscale of Lhe SF 36 (z=-2.817, p=0.005). In patients with mixed or rapid-cycling episodes, SF-36 subscale scores except general health and pain were Found to be lower.Limitations: Our sample may fail to reflect the general BD population; the patients were included consecutively and consisted of a majority of female patients.Conclusions: CHT plays an important role in the clinical expression of BP-I disorder and having mixed/rapid-cycling episodes negatively affects both physical and mental components, as measured by the SF-36. While both males and females reported experiencing sexual abuse, female BP-I patients complained about pain more often. It is suggested that treatment of BP-1 patients with a history of CHT should differ from that provided for patients with no CHT history.Yayın Executive functions and thyroid volumes in bipolar patients on lithium treatment(In House Publications, 2014-09-30) Fıstıkçı, Nurhan; Cantürk, Gülsüm; Saatçioğlu, İbrahim Ömer; Erten, Evrim; Keyvan, Ali; Turan, NurtenAim: The purpose of this study was to investigate the relationship between executive functions and thyroid ultrasound parameters in remitted bipolar patients who were on lithium treatment. Methods: In the current study, 25 remitted patients with diagnoses of Bipolar I Disorder having blood lithium, and thyroid hormone levels within the normal range were consecutively enrolled. Healthy control group consisted of 25 euthyroid people matched as an age, sex and education level with the patients. Semi-structured sociodemographic and clinical form, the Structured Clinical Interview for DSM-IV Axis I Disorders, the Montreal Cognitive Assessment (MoCA), the Hamilton Depression Scale, Young Mania Rating Scale, thyroid ultrasonography and the Wisconsin Card Sorting Test (WCST) were applied to both groups. Within the patient group, correlation analysis was performed between WCST performance and thyroid volume. Results: In the present study, no significant difference was found between the bipolar and the healthy control groups regarding the executive functions as measured via WCST. In the bipolar patients, there were no statistically significant correlations among WCST scores and thyroid volumes. Conclusion: Thyroid volumes are not appeared to be associated with executive functions in euthymic bipolar patients.Yayın Paraoxonase (PON1) L55M and Q192R polymorphisms in major depressive disorder and bipolar disorder(Psikofarmakoloji Derneği adına Mesut Çetin, 2017) Yıldız, Mesut; Çam Çelikel, Feryal; Ateş, Ömer; Erdoğan Taycan, Serap; Benli, İsmail; Demir, OsmanObjective: Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depressive disorder and bipolar disorder. The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depressive disorder and bipolar disorder. Methods: PON1 L55M and Q192R single nucleotide polymorphisms were analyzed in a group consisted of 100 patients with major depressive disorder, and 100 patients with bipolar disorder and 96 healthy controls. Polymorphisms were analyzed by using polymerase chain reaction. Results: There were no statistically significant differences between groups for the existence of PON1 genotypes. Additionally, there was no association between the PON1 genotypes and disease variables in both depressed and bipolar patients. Conclusions: Evaluating the different stages of patients with mood disorders and examining the connection between PON1 polymorphisms and treatment outcomes will help us to clarify the relationship between PON1 and mood disorders.
