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Yayın Monitoring of a laboratory-scale inland-delta formation using a structured-light system(Blackwell Publishing Ltd, 2016-06) Akça, Mehmet Devrim; Seybold, Hansjörg J.A reduced complexity model, which simulates the process of fluvial inland-delta formation, has been developed in a previous study. The results have been compared and validated with a laboratory experiment. This work elaborates the laboratory investigation in which an experimental inland delta is generated and its eroding topography is measured using a structured-light 3D scanner. The least squares 3D (LS3D) co-registration and comparison method is used for alignment as well as for comparing data epochs both spatially and temporally. A spatial precision value of around ±50 ?m (1/20 000) is achieved. A series of high-quality digital elevation models (DEMs) are generated and the space-time evolution of the inland delta is monitored and analysed, in terms of slope and topography dynamics, in the consecutive DEM layers. The combination of high-resolution scanning together with high-precision co-registration techniques allows investigation of the details of the space-time variability of the sedimentation-deposition patterns to be used for geomorphological analysis.Yayın The comparison of functional connectivity in Parkinson’s Disease patients with and without Parkin gene mutations(Turkish Neuropsychiatric Society, 2025-06-19) Çebi, Merve; Ay, Ulaş; Kıçik, Ani; Erdoğdu, Emel; Tepgeç, Fatih; Uyguner, Zehra Oya; Tüfekçioğlu, Zeynep; Samancı, Bedia; Bilgiç, Başar; Emre, Murat; Demiralp, Tamer; Hanağası, Haşmet AyhanIntroduction: Mapping the functional connectivity of brain regions became appealing in recent research in neurology. Accordingly, a growing body of evidence shows resting-state functional connectivity (rsFC) changes in neurodegenerative disorders including Parkinson’s Disease (PD). As characterised by extensive and progressive dopaminergic loss in the substantia nigra, PD emerges with serious motor and non-motor dysfunctions. In the literature, the minority of PD cases have been associated with certain genetic mutations. The aim of this study was to investigate the rsFC in a group of PD patients having Parkin gene mutation. Method: Twelve PD patients with Parkin mutation (PP-PD), 12 PD patients without Parkin mutation (PN-PD) and 12 healthy controls (HC) were included in the study. All participants underwent a resting-state functional magnetic resonance imaging as well as a neuropsychological assessment and clinical examination. Results: Results indicated that PP-PD had longer disease duration, a higher rate of dyskinesia and lower scores on complex visual perception tests. The resting state networks showed that all PD (consisting of PP-PD and PN-PD) and PP-PD groups had increased functional connectivity in the frontoparietal network as compared to the HC. In addition, the PP-PD group displayed decreased functional connectivity in the dorsal attention network compared to the PN-PD. Conclusion: In conclusion, our data suggests that PD with Parkin gene mutation might be emerging with distinct resting state functional connectivity changes in the brain.
