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Yayın Solution of inverse source problem in thermoacoustic imaging(Işık Üniversitesi, 2022-06-14) Elmas, Demet; Uzun, Banu; Işık Üniversitesi, Lisansüstü Eğitim Enstitüsü, Matematik Doktora ProgramıThis study aims to investigate and explore accurate analytical inverse solutions of thermoacoustic wave equation involved in microwave induced thermoacoustic imaging of breast. Using boundary conditions, we aimed to find more realistic solutions. For cross-sectional two-dimensional thermoacoustic imaging of breast, we explored solution of the wave equation using layered tissue model consisting of concentric annular layers on a cylindrical cross-section. To obtain the forward and inverse solutions of the thermoacoustic wave equation, we derived the Green’s function involving Bessel and Hankel functions by employing the geometrical and acoustic parameters (densities and velocities) of layered media together with temporal initial condition, radiation conditions and continuity conditions on boundaries of layers. The image reconstruction based on this approach involves the layers parameters as the a priori information which can be estimated from the acquired thermoacoustic data. To test and compare our layered solution with conventional solution based on homogeneous medium assumption, we performed simulations using numerical test phantoms consisting of sources distributed in the layered structure. After then, we derived more general integral solution for thermoacoustic wave equation in frequency domain for an arbitrary convex domain in R³.
