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Yayın Çizge evrişim ağı kullanarak patojen-konak ağlarında protein etkileşim tahmini(IEEE, 2021-06-09) Koca, Mehmet Burak; Karadeniz, İlknur; Nourani, Esmaeil; Sevilgen, Fatih ErdoğanProteinler yaşamsal faaliyetlerin gerçekleşmesinde kritik rol oynayan biyolojik moleküllerdir. Konak canlı proteinleri ile patojen proteinleri arasındaki etkileşimler patojenkonak etkileşim (PHI) ağlarını oluşturmaktadır. Bu iki parçalı etkileşim ağları patojenin hangi yaşamsal faaliyetleri etkilediğini belirlemede ve dolayısıyla sebep olabileceği hastalıkların tespitinde büyük öneme sahiptir. Proteinler arası etkileşimlerin laboratuvar ortamında tespiti hem zaman alıcı hem de maliyetlidir. Deneysel olarak saptanabilen etkileşim sayısının kısıtlı olması ve bazı etkileşimlerin gözden kaçması hesaplamalı tahmin yöntemlerinin geliştirilmesine önayak olmaktadır. Bu çalışmada PHI ağlarında protein etkileşim tahmini yapmayı sağlayan çizge evrişim ağı (GCN) tabanlı bir yöntem sunulmaktadır. Gözetimsiz olarak eğitilen GCN modeli (GraphSAGE) topolojik bilginin yanı sıra temel öznitelik olarak amino asit dizilimlerini kullanmaktadır. Bu çalışma bildiğimiz kadarıyla PHI ağlarında GCN tabanlı etkileşim tahmini sağlayan ilk çalışmadır. Deneysel sonuçlar geliştirilen modelin kıyaslama için kullanılan PHI veri seti üzerinde yüksek performanslı algoritmalardan %10 daha iyi performans göstererek %96 oranında doğrulukla etkileşim tahmini yaptığını göstermektedir.Yayın Convolutional attention network for MRI-based Alzheimer's disease classification and its interpretability analysis(IEEE, 2021-09-17) Türkan, Yasemin; Tek, Faik BorayNeuroimaging techniques, such as Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET), help to identify Alzheimer's disease (AD). These techniques generate large-scale, high-dimensional, multimodal neuroimaging data, which is time-consuming and difficult to interpret and classify. Therefore, interest in deep learning approaches for the classification of 3D structural MRI brain scans has grown rapidly. In this research study, we improved the 3D VGG model proposed by Korolev et al. [2]. We increased the filters in the 3D convolutional layers and then added an attention mechanism for better classification. We compared the performance of the proposed approaches for the classification of Alzheimer's disease versus mild cognitive impairments and normal cohorts on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset. We observed that both the accuracy and area under curve results improved with the proposed models. However, deep neural networks are black boxes that produce predictions that require further explanation for medical usage. We compared the 3D-data interpretation capabilities of the proposed models using four different interpretability methods: Occlusion, 3D Ultrametric Contour Map, 3D Gradient-Weighted Class Activation Mapping, and SHapley Additive explanations (SHAP). We observed that explanation results differed in different network models and data classes.Yayın Convolutional neural network (CNN) algorithm based facial emotion recognition (FER) system for FER-2013 dataset(IEEE, 2022-11-18) Ezerceli, Özay; Eskil, Mustafa TanerFacial expression recognition (FER) is the key to understanding human emotions and feelings. It is an active area of research since human thoughts can be collected, processed, and used in customer satisfaction, politics, and medical domains. Automated FER systems had been developed and have been used to recognize humans’ emotions but it has been a quite challenging problem in machine learning due to the high intra-class variation. The first models were using known methods such as Support Vector Machines (SVM), Bayes classifier, Fuzzy Techniques, Feature Selection, Artificial Neural Networks (ANN) in their models but still, some limitations affect the accuracy critically such as subjectivity, occlusion, pose, low resolution, scale, illumination variation, etc. The ability of CNN boosts FER accuracy. Deep learning algorithms have emerged as the greatest way to produce the best results in FER in recent years. Various datasets were used to train, test, and validate the models. FER2013, CK+, JAFFE and FERG are some of the most popular datasets. To improve the accuracy of FER models, one dataset or a mix of datasets has been employed. Every dataset includes limitations and issues that have an impact on the model that is trained for it. As a solution to this problem, our state-of-the-art model based on deep learning architectures, particularly convolutional neural network architectures (CNN) with supportive techniques has been implemented. The proposed model achieved 93.7% accuracy with the combination of FER2013 and CK+ datasets for FER2013.Yayın Subset selection for tuning of hyper-parameters in artificial neural networks(IEEE, 2017) Aki, K.K.Emre; Erkoç, Tuğba; Eskil, Mustafa TanerHyper-parameters of a machine learning architecture define its design. Tuning of hyper-parameters is costly and for large data sets outright impractical, whether it is performed manually or algorithmically. In this study we propose a Neocognitron based method for reducing the training set to a fraction, while keeping the dynamics and complexity of the domain. Our approach does not require processing of the entire training set, making it feasible for larger data sets. In our experiments we could successfully reduce the MNIST training data set to less than 2.5% (1,489 images) by processing less than 10% of the 60K images. We showed that the reduced data set can be used for tuning of number of hidden neurons in a multi-layer perceptron.Yayın Animal sound classification using a convolutional neural network(IEEE, 2018-12-06) Şaşmaz, Emre; Tek, Faik BorayIn this paper, we investigate the problem of animal sound classification using deep learning and propose a system based on convolutional neural network architecture. As the input to the network, sound files were preprocessed to extract Mel Frequency Cepstral Coefficients (MFCC) using LibROSA library. To train and test the system we have collected 875 animal sound samples from an online sound source site for 10 different animal types. We report classification confusion matrices and the results obtained by different gradient descent optimizers. The best accuracy of 75% was obtained by Nesterov-accelerated Adaptive Moment Estimation (Nadam).Yayın Uzaktan algılanan görüntülerde bina yoğunluğu kestirimi için derin öğrenme(Institute of Electrical and Electronics Engineers Inc., 2019-09) Süberk, Nilay Tuğçe; Ateş, Hasan FehmiBu bildiri, derin öğrenme yöntemleri uygulayarak uzaktan algılamalı optik görüntülerde bina yoğunluğunun noktasal olarak kestirilmesi ile ilgilidir. Bu çalışma kapsamında, evrişimsel sinir ağına (ESA) dayalı derin öğrenme yöntemlerine başvurulmuştur. Önceden eğitilmiş, VGG-16 ve FCN-8s derin mimarileri bu probleme uyarlanmış ve ince ayar verilerek eğitilmiştir. Kestirilen değerler yerleşim bölgelerinde bina yoğunluk haritası oluşturmak için kullanılmıştır. Her iki mimarinin karşılaştırmalı benzetim sonuçları, güdümlü eğitim için binaları gösteren detaylı haritalara ihtiyaç duyulmadan hassas yoğunluk kestirimi yapılabileceğini göstermektedir.
