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Yayın Computational model of the ventricular action potential in adult spontaneously hypertensive rats(2003-09-01) Padmala, Srikanth; Demir, Sıddıka SemahatIntroduction: Cardiac hypertrophy has substantial clinical significance because many hypertrophic cells have markedly prolonged repolarization behavior, which may lead to increased risk for cardiac arrhythmias. Spontaneously hypertensive rat (SHR) is one model of hypertension that is studied extensively and is considered to be the best laboratory model of human hypertension. We extended our previously published model of the rat ventricular myocyte to simulate the effects of hypertrophy in SHR. Methods and Results: In SHR it has been shown that the membrane capacitance is increased, the density of transient outward K+ current is decreased, the sarcoplasmic reticulum Ca 2+ ATPase activity is reduced, and the cell volumes are increased compared to those of the normal rat. We introduced these changes into our previous model of the rat ventricular myocyte and simulated the ventricular action potential of SHR. Our results demonstrated increased action potential duration (APD) and increased peak systolic value of the intracellular calcium transient in SHR. Simulations with reduced extracellular K+ concentration ([K+]o) have shown that there is increased APD shortening in SHR compared to that of the normal rat. Conclusions: Our computational model qualitatively simulated the electrophysiologic changes observed in SHR and provided the plausible mechanistic linkage between the prolonged APD and increased inotropy. Our model results also demonstrated the electrophysiologic changes observed with reduced [K+]o in SHR, a finding that is clinically significant in hypertensive patients with left ventricular hypertrophy undergoing diuretic treatment.Yayın Evolutionary route to diploidy and sex(National Academy of Sciences, 2001-11-20) Tüzel, Erkan; Sevim, Volkan; Erzan, AyşeBy using a bit-string model of evolution, we find a successful route to diploidy and sex in simple organisms. Allowing the sexually reproducing diploid individuals to also perform mitosis, as they do in a haploid-diploid cycle, leads to the complete takeover of the population by sexual diploids. This mechanism is so robust that even the accidental conversion and pairing of only two diploids give rise to a sexual population.Yayın Evcil hayvanlar için eylem tanıma ve izleme sistemi(Institute of Electrical and Electronics Engineers Inc, 2018-07-05) Demir, Güneycan; Tüysüz Erman, AyşegülÜlkemizde dünyada olduğu gibi evcil hayvan sahiplenme oranı gün geçtikçe artmaktadır. Evcil hayvan sahipleri hayvanlarının sağlıklarını takip etmek için çeşitli araçlar ve yöntemler kullanmaktadırlar. Hayvan sağlığının takibi için kullanılan yöntemlerin başında hayvanın hareketlilik seviyesinin gözlemlenmesi gelmektedir. Hareketlik seviyesinde azalma çoğu hayvan hastalığında ilk ve en belirgin semptomlardandır. Bu çalışmada, evcil hayvanların eylemlerinin otomatik olarak tanınması ve takibi için bir Nesnelerin Interneti sistemi geliştirilmiştir. Sistemde evcil hayvanın tasmasına takılan bir sensör düğüm, bu düğümün topladığı verileri bulut mimarisine aktaran bir mobil uygulama ve bulut mimaride verileri otomatik olarak sınıflandıran ve görselleştiren bir yazılım ve arayüz bulunmaktadır. Elde edilen veriler ile evcil hayvanın bir gün içindeki hareketliliği farklı eylem sınıfları (oturma, yürüme, koşma) gösterilerek belirlenmiştir. Çalışmada denek olarak köpek kullanılmıştır.Yayın Animal sound classification using a convolutional neural network(IEEE, 2018-12-06) Şaşmaz, Emre; Tek, Faik BorayIn this paper, we investigate the problem of animal sound classification using deep learning and propose a system based on convolutional neural network architecture. As the input to the network, sound files were preprocessed to extract Mel Frequency Cepstral Coefficients (MFCC) using LibROSA library. To train and test the system we have collected 875 animal sound samples from an online sound source site for 10 different animal types. We report classification confusion matrices and the results obtained by different gradient descent optimizers. The best accuracy of 75% was obtained by Nesterov-accelerated Adaptive Moment Estimation (Nadam).Yayın Effects of laurocerasus officinalis roem (Cherry Laurel) on cognitive function and neurobiochemical pathways in a streptozotocin-induced nontransgenic Alzheimer's disease model(Multidisciplinary Digital Publishing Institute (MDPI), 2026-03-08) Özsoy, Fulya; Yanar, Karolin; Sayılı, Uğurcan; Atukeren, Pınar; Uzun, HafizeBackground: This study investigated the effects of Laurocerasus officinalis Roem (cherry laurel; CL), a traditionally consumed fruit, on cognitive performance and selected neurobiochemical and metabolic pathways in a nontransgenic streptozotocin (STZ)-induced Alzheimer’s disease (i.c.v. STZ) model and an STZ-induced type 2 diabetes mellitus (T2DM; i.p. STZ) model. Method: Fifty-seven adult male Sprague–Dawley rats were allocated to control, T2DM, and Alzheimer (ALZ) model groups, with subgroup interventions including CL supplementation and, in the T2DM model, metformin as a comparator. Spatial learning and memory were assessed using the Morris Water Maze. Serum and brain tissue levels of GSK3-β, glutathione (GSH), interleukin-1 (IL-1), GLUT4, GLP-1, β-amyloid (Aβ), and acetylcholinesterase (AChE) were quantified. Results: Serum GSK3-β levels did not differ significantly between groups, whereas brain tissue GSK3-β showed significant between-group differences. CL increased GSH levels in both models, with significant elevations in serum and brain tissue GSH in the ALZ model following CL administration; in the T2DM model, GSH increased after both CL and metformin. In the ALZ model, CL was associated with decreased serum Aβ and AChE levels and improved Morris Water Maze performance, reflected by reduced escape latencies. Conclusions: CL supplementation was associated with antioxidant enhancement and modulation of amyloid- and cholinergic-related measures, alongside improved spatial learning performance in the STZ-induced nontransgenic ALZ model. In addition, CL reduced blood glucose in the T2DM model. Given the likely contribution of fruit phytochemicals (including total phenolics), further studies are warranted to better define the bioactive composition and mechanisms underlying these effects.
