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Yayın A new method for the source localization in sectionally homogeneous bounded domains involving finitely many inner interfaces of arbitrary shapes(Pergamon-Elsevier Science, 2001-05) İdemen, Mehmet Mithat; Alkumru, AliA new method to localize a static point source buried in a nonhomogeneous bounded domain composed of finitely many homogeneous parts separated by interfaces of arbitrary shapes was established. The source can be a simple point charge or current or a dipole of them. The method requires only the knowledge of the potential function Phi (x, y, z) at five or six points on the outermost interface depending on whether the source is simple or dipole. The new and basic feature of the method consists of determining the potential function Phi (0)(x, y, z) which would be observed if the whole space was filled with a homogeneous material. Then, in the case of a simple source, the position P-0 as well as the strengths can be determined, in general, by solving a system of three linear algebraic equations. When the source consists of a dipole, its position P-0 and moment (p) over right arrow can be found by solving a system of six nonlinear algebraic equations. The determination of Phi (0) P-0 and s (or (p) over right arrow) is achieved iteratively by solving the above-mentioned algebraic equations along with a singular integral equation satisfied by Phi (0) Some illustrative examples show the applicability and accuracy of the method. The method can have effective applications in heat conduction, matter diffusion, electrostatics, steady-state current flow, electroencephalography, electrocardiography, etc.Yayın Effects of laurocerasus officinalis roem (Cherry Laurel) on cognitive function and neurobiochemical pathways in a streptozotocin-induced nontransgenic Alzheimer's disease model(Multidisciplinary Digital Publishing Institute (MDPI), 2026-03-08) Özsoy, Fulya; Yanar, Karolin; Sayılı, Uğurcan; Atukeren, Pınar; Uzun, HafizeBackground: This study investigated the effects of Laurocerasus officinalis Roem (cherry laurel; CL), a traditionally consumed fruit, on cognitive performance and selected neurobiochemical and metabolic pathways in a nontransgenic streptozotocin (STZ)-induced Alzheimer’s disease (i.c.v. STZ) model and an STZ-induced type 2 diabetes mellitus (T2DM; i.p. STZ) model. Method: Fifty-seven adult male Sprague–Dawley rats were allocated to control, T2DM, and Alzheimer (ALZ) model groups, with subgroup interventions including CL supplementation and, in the T2DM model, metformin as a comparator. Spatial learning and memory were assessed using the Morris Water Maze. Serum and brain tissue levels of GSK3-β, glutathione (GSH), interleukin-1 (IL-1), GLUT4, GLP-1, β-amyloid (Aβ), and acetylcholinesterase (AChE) were quantified. Results: Serum GSK3-β levels did not differ significantly between groups, whereas brain tissue GSK3-β showed significant between-group differences. CL increased GSH levels in both models, with significant elevations in serum and brain tissue GSH in the ALZ model following CL administration; in the T2DM model, GSH increased after both CL and metformin. In the ALZ model, CL was associated with decreased serum Aβ and AChE levels and improved Morris Water Maze performance, reflected by reduced escape latencies. Conclusions: CL supplementation was associated with antioxidant enhancement and modulation of amyloid- and cholinergic-related measures, alongside improved spatial learning performance in the STZ-induced nontransgenic ALZ model. In addition, CL reduced blood glucose in the T2DM model. Given the likely contribution of fruit phytochemicals (including total phenolics), further studies are warranted to better define the bioactive composition and mechanisms underlying these effects.
