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Yayın Elevated sTREM2 and NFL levels in patients with sepsis associated encephalopathy(Taylor & Francis, 2023-03-04) Orhun, Günseli; Esen, Figen; Yılmaz, Vuslat; Ulusoy, Canan; Şanlı, Elif; Yıldırım, Elif; Gürvit, İbrahim Hakan; Ergin Özcan, Perihan; Sencer, Serra; Bebek, Nerses; Tüzün, ErdemPurpose: Sepsis-associated encephalopathy (SAE) is a common manifestation of sepsis that may lead to cognitive decline. Our aim was to investigate whether the neurofilament light chain (NFL) and soluble triggering receptor expressed on myeloid cells 2 (sTREM2) could be utilized as prognostic biomarkers in SAE. Materials and methods: In this prospective observational study, baseline serum levels of sTREM2 and cerebrospinal fluid (CSF) levels of sTREM2 and NFL were measured by ELISA in 11 SAE patients and controls. Patients underwent daily neurological examination. Brain magnetic resonance imaging (MRI) and standard electroencephalography (EEG) were performed. Cognitive dysfunction was longitudinally assessed after discharge in 4 SAE patients using the Mini-Mental State Examination (MMSE) and Addenbrooke’s Cognitive Examination-Revised (ACE-R) tests. Results: SAE patients showed higher CSF sTREM2 and NFL levels than controls. sTREM2 and NFL levels were not correlated with the severity measures of sepsis. Three months after discharge, 2 SAE patients displayed ACE-R scores congruent with mild cognitive impairment (MCI), persisting in one patient 12 months after discharge. SAE patients with MCI showed higher CSF NFL levels, bacteremia, and abnormal brain MRI. Patients with increased serum/CSF sTREM2 levels showed trends towards displaying poorer attention/orientation and visuo-spatial skills. Conclusions: sTREM2 and NFL levels may serve as a prognostic biomarker for cognitive decline in SAE. These results lend further support for the involvement of glial activation and neuroaxonal degeneration in the physiopathology of SAE.Yayın The mediating effect of self compassion in the relationship between job stress and burnout levels among employees(SAGE Publications Inc., 2026-02-13) Günay, Ezgi; Ünver, Buket; Yılmaz, SimayObjective: This study investigates the role of self-compassion as a mediator in the relationship between job stress and burnout among employees. While job stress is widely recognized as a critical factor leading to burnout, it has been suggested that self-compassion may be associated with a reduction in these negative effects. Method: Participants were 429 actively employed adults living in Turkey (50.6% female). The data were gathered using an online administration of standardized psychological scales, that is, Job Stressor Appraisal Scale, Copenhagen Burnout Scale, and Self-Compassion Scale. Four dimensions of work stress “Role and Workload, Role Inadequacy, Organizational Rules & Practices, and Subordinate Relations” are taken into consideration in the volumetric model. Path analysis with bootstrapping (5,000 resamples) was implemented using Mplus statistical software, with gender, economic condition, and way of working during COVID-19 as covariates. Findings: The model fit was acceptable in path analysis. Role and workload and role inadequacy had a significant direct impact on burnout. Self-compassion had a significant mediating impact on the relationship between role and workload and burnout and the relationship between role inadequacy and burnout. Conversely, for organizational rules and practices and subordinate relations, both direct and mediating effects were non-significant. The model accounted for 21% and 52% for variance in self-compassion and burnout, respectively. Conclusion: This study emphasises the mediating role of self-compassion in the effect of job stressors on burnout. These findings suggest that interventions promoting self-compassion in the workplace may be effective in reducing employee burnout.
