Effect of magnesium and osteoblast cell presence on hydroxyapatite formation on (Ti,Mg)N thin film coatings

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dc.authorid0000-0001-8170-7929
dc.authorid0000-0002-0318-6037
dc.authorid0000-0003-0997-1404
dc.authorid0000-0002-0878-7288
dc.authorid0000-0002-5093-6013
dc.authorid0000-0003-3549-0049
dc.contributor.authorÖnder, Sakipen_US
dc.contributor.authorÇalıkoğlu Koyuncu, Ayşe Ceren Erenen_US
dc.contributor.authorKöse, Gamze Torunen_US
dc.contributor.authorKazmanlı, Kürşat Muhammeten_US
dc.contributor.authorKök, Fatma Neşeen_US
dc.contributor.authorÜrgen, Mustafaen_US
dc.date.accessioned2016-12-27T08:51:52Z
dc.date.available2016-12-27T08:51:52Z
dc.date.issued2016-07-19
dc.departmentIşık Üniversitesi, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.departmentIşık University, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.description.abstractTiN and (Ti,Mg)N thin film coatings were deposited on Ti substrates by an arc-physical vapor deposition technique. The effect of cell presence on hydroxyapatite (HA) formation was investigated using surfaces with four different Mg contents (0, 8.1, 11.31, and 28.49 at.%). Accelerated corrosion above 10 at.% Mg had a negative effect on the performance in terms of both cell proliferation and mineralization. In the absence of cells, Mg-free TiN coatings and low-Mg (8.1 at.%)-doped (Ti,Mg)N surfaces led to an early HA deposition (after 7 days and 14 days, respectively) in cell culture medium (DMEM), but the crystallinity was low. More crystalline HA structures were obtained in the presence of the cells. HA deposits with an ideal Ca/P ratio were obtained at least a week earlier, at day 14, in TiN and low-Mg (8.1 at.%)-doped (Ti,Mg)N compared with that of high-Mg-containing surfaces (>10 at.%). A thicker mineralized matrix was formed on low-Mg (8.1 at.%)-doped (Ti,Mg)N relative to that of the TiN sample. Low-Mg doping (<10 at.%) into TiN coatings resulted in better cell proliferation and thicker mineralized matrix formation, so it could be a promising alternative for hard tissue applications.en_US
dc.description.sponsorshipThis study was supported by "The Scientific and Research Council of Turkey" (TUBITAK - Project #112M339). The authors gratefully thank the ITU Graduate School of Science, Engineering and Technology for ITU-BAP Graduate Student Project #34525en_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationÖnder, S., Çalıkoğlu Koyuncu, A. C., Torun Köse, G., Kazmanlı, K., Kök, F. N. & Ürgen, M. (2016). Effect of magnesium and osteoblast cell presence on hydroxyapatite formation on (ti,mg)N thin film coatings. JOM, 69(7), 1195-1205. doi:10.1007/s11837-016-2029-4en_US
dc.identifier.doi10.1007/s11837-016-2029-4
dc.identifier.endpage1205
dc.identifier.issn1047-4838
dc.identifier.issn1543-1851
dc.identifier.issue7
dc.identifier.scopus2-s2.0-84978704698
dc.identifier.scopusqualityQ2
dc.identifier.startpage1195
dc.identifier.urihttps://hdl.handle.net/11729/1160
dc.identifier.urihttp://dx.doi.org/10.1007/s11837-016-2029-4
dc.identifier.volume69
dc.identifier.wosWOS:000403643200010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakScience Citation Index Expanded (SCI-EXPANDED)en_US
dc.institutionauthorÖnder, Sakipen_US
dc.institutionauthorid0000-0001-8170-7929
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherSpringeren_US
dc.relation.ispartofJOMen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCell cultureen_US
dc.subjectCell proliferationen_US
dc.subjectCellsen_US
dc.subjectCoatingsen_US
dc.subjectCytologyen_US
dc.subjectDepositionen_US
dc.subjectHard coatingsen_US
dc.subjectHydroxyapatiteen_US
dc.subjectPhysical vapor depositionen_US
dc.subjectSemiconductor dopingen_US
dc.subjectThin filmsen_US
dc.subjectTin depositsen_US
dc.subjectTitanium compoundsen_US
dc.subjectTitanium nitrideen_US
dc.subjectAbsence of cellsen_US
dc.subjectAccelerated corrosionen_US
dc.subjectArc physical vapor depositionen_US
dc.subjectCell culture mediumsen_US
dc.subjectHydroxyapatite formationsen_US
dc.subjectMatrix formationen_US
dc.subjectOsteoblast cellsen_US
dc.subjectThin-film coatingsen_US
dc.subjectVapor depositionen_US
dc.subjectPulsed-laser depositionen_US
dc.subjectCalcium-phosphateen_US
dc.subjectSubstituted hydroxyapatiteen_US
dc.subjectIn-vitroen_US
dc.subjectThermal-stabilityen_US
dc.subjectTitanium surfaceen_US
dc.subjectDental implantsen_US
dc.subjectBoneen_US
dc.subjectAdhesionen_US
dc.subjectBehavioren_US
dc.titleEffect of magnesium and osteoblast cell presence on hydroxyapatite formation on (Ti,Mg)N thin film coatingsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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