Analyzing language ability in first-episode psychosis and their unaffected siblings: a diffusion tensor imaging tract-based spatial statistics analysis study

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dc.authorid0000-0001-9377-3560
dc.authorid0000-0003-2779-3947
dc.authorid0000-0002-6009-1085
dc.authorid0000-0002-0611-1858
dc.authorid0000-0002-1405-9754
dc.authorid0000-0002-3385-4665
dc.authorid0000-0002-9062-8314
dc.contributor.authorÇabuk, Tuğçeen_US
dc.contributor.authorŞahin Çevik, Didenuren_US
dc.contributor.authorÇakmak, Işık Batuhanen_US
dc.contributor.authorYılmaz Kafalı, Helinen_US
dc.contributor.authorŞenol, Bedirhanen_US
dc.contributor.authorAvcı, Hanifeen_US
dc.contributor.authorKarlı Oğuz, Kaderen_US
dc.contributor.authorToulopoulou, Timotheaen_US
dc.date.accessioned2025-08-20T06:57:57Z
dc.date.available2025-08-20T06:57:57Z
dc.date.issued2024-11
dc.departmentIşık Üniversitesi, İktisadi, İdari ve Sosyal Bilimler Fakültesi, Psikoloji Bölümüen_US
dc.departmentIşık University, Faculty of Economics, Administrative and Social Sciences, Department of Psychologyen_US
dc.descriptionThis work was supported by The Scientific and Technological Research Council of Turkey (T\u00DCB\u0130TAK) (Grant Number: 119K410 and 120K729) to TT.en_US
dc.description.abstractSchizophrenia (SZ) is a highly heritable mental disorder, and language dysfunctions play a crucial role in diagnosing it. Although language-related symptoms such as disorganized speech were predicted by the polygenic risk for SZ which emphasized the common genetic liability for the disease, few studies investigated possible white matter integrity abnormalities in the language-related tracts in those at familial high-risk for SZ. Also, their results are not consistent. In this current study, we examined possible aberrations in language-related white matter tracts in patients with first-episode psychosis (FEP, N = 20), their siblings (SIB, N = 20), and healthy controls (CON, N = 20) by applying whole-brain Tract-Based Spatial Statistics and region-of-interest analyses. We also assessed language ability by Thought and Language Index (TLI) using Thematic Apperception Test (TAT) pictures and verbal fluency to see whether the scores of these language tests would predict the differences in these tracts. We found significant alterations in language-related tracts such as inferior longitudinal fasciculus (ILF) and uncinate fasciculus (UF) among three groups and between SIB and CON. We also proved partly their relationship with the language test as indicated by the significant correlation detected between TLI Impoverished thought/language sub-scale and ILF. We could not find any difference between FEP and CON. These results showed that the abnormalities, especially in the ILF and UF, could be important pathophysiological vulnerability indexes of schizophrenia. Further studies are required to understand better the role of language as a possible endophenotype in schizophrenia with larger samples.en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumuen_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationÇabuk, T., Şahin Çevik, D., Çakmak, I. B., Yılmaz Kafalı, H., Şenol, B., Avcı, H., Karlı Oğuz, K. & Toulopoulou, T. (2024). Analyzing language ability in first-episode psychosis and their unaffected siblings: a diffusion tensor imaging tract-based spatial statistics analysis study. Journal of Psychiatric Research, 179, 229-237. doi:10.1016/j.jpsychires.2024.09.021en_US
dc.identifier.doi10.1016/j.jpsychires.2024.09.021
dc.identifier.endpage237
dc.identifier.issn0022-3956
dc.identifier.issn1879-1379
dc.identifier.pmid39321521
dc.identifier.scopus2-s2.0-85204476320
dc.identifier.scopusqualityQ1
dc.identifier.startpage229
dc.identifier.urihttps://hdl.handle.net/11729/6629
dc.identifier.urihttps://doi.org/10.1016/j.jpsychires.2024.09.021
dc.identifier.volume179
dc.identifier.wosWOS:001324574100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScience Citation Index Expanded (SCI-EXPANDED)en_US
dc.indekslendigikaynakSocial Sciences Citation Index (SSCI)en_US
dc.institutionauthorYılmaz Kafalı, Helinen_US
dc.institutionauthorid0000-0002-6009-1085
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofJournal of Psychiatric Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiffusion tensor imagingen_US
dc.subjectFirst-episode psychosisen_US
dc.subjectFormal thought disorderen_US
dc.subjectLanguageen_US
dc.subjectSchizophreniaen_US
dc.subjectSiblingen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectBrainen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectLanguage disordersen_US
dc.subjectMaleen_US
dc.subjectPsychotic disordersen_US
dc.subjectWhite matteren_US
dc.subjectYoung adulten_US
dc.subjectAgeen_US
dc.subjectArticleen_US
dc.subjectBrain analysisen_US
dc.subjectClinical articleen_US
dc.subjectClinical featureen_US
dc.subjectComparative studyen_US
dc.subjectControlled studyen_US
dc.subjectDemographicsen_US
dc.subjectEducational statusen_US
dc.subjectInferior longitudinal fasciculusen_US
dc.subjectLanguage abilityen_US
dc.subjectPersonality assessmenten_US
dc.subjectPsychosisen_US
dc.subjectThematic apperception testen_US
dc.subjectThought and language indexen_US
dc.subjectUncinate fasciculusen_US
dc.subjectDiagnostic imagingen_US
dc.subjectEtiologyen_US
dc.subjectLanguage disabilityen_US
dc.subjectPathologyen_US
dc.subjectPathophysiologyen_US
dc.titleAnalyzing language ability in first-episode psychosis and their unaffected siblings: a diffusion tensor imaging tract-based spatial statistics analysis studyen_US
dc.typeArticleen_US
dspace.entity.typePublicationen_US

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