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The comparison of functional connectivity in Parkinson’s Disease patients with and without Parkin gene mutations
(Turkish Neuropsychiatric Society, 2025-06-19) Çebi, Merve; Ay, Ulaş; Kıçik, Ani; Erdoğdu, Emel; Tepgeç, Fatih; Uyguner, Zehra Oya; Tüfekçioğlu, Zeynep; Samancı, Bedia; Bilgiç, Başar; Emre, Murat; Demiralp, Tamer; Hanağası, Haşmet Ayhan
Introduction: Mapping the functional connectivity of brain regions became appealing in recent research in neurology. Accordingly, a growing body of evidence shows resting-state functional connectivity (rsFC) changes in neurodegenerative disorders including Parkinson’s Disease (PD). As characterised by extensive and progressive dopaminergic loss in the substantia nigra, PD emerges with serious motor and non-motor dysfunctions. In the literature, the minority of PD cases have been associated with certain genetic mutations. The aim of this study was to investigate the rsFC in a group of PD patients having Parkin gene mutation. Method: Twelve PD patients with Parkin mutation (PP-PD), 12 PD patients without Parkin mutation (PN-PD) and 12 healthy controls (HC) were included in the study. All participants underwent a resting-state functional magnetic resonance imaging as well as a neuropsychological assessment and clinical examination. Results: Results indicated that PP-PD had longer disease duration, a higher rate of dyskinesia and lower scores on complex visual perception tests. The resting state networks showed that all PD (consisting of PP-PD and PN-PD) and PP-PD groups had increased functional connectivity in the frontoparietal network as compared to the HC. In addition, the PP-PD group displayed decreased functional connectivity in the dorsal attention network compared to the PN-PD. Conclusion: In conclusion, our data suggests that PD with Parkin gene mutation might be emerging with distinct resting state functional connectivity changes in the brain.
Investigation of symptom-specific functional connectivity patterns in Parkinson’s disease
(Springer-Verlag Italia S.R.L., 2025-06-14) Kıçik, Ani; Bayram, Ali; Erdoğdu, Emel; Kurt, Elif; Sarıdede, Dilek Betül; Cengiz, Sevim; Bilgiç, Başar; Hanağası, Haşmet; Öztürk Işık, Esin; Gürvit, Hakan; Tüzün, Erdem; Demiralp, Tamer
Parkinson’s disease (PD) is a complex neurodegenerative disease, characterized by pronounced heterogeneity in symptoms. This study investigates the functional connectivity (FC) patterns associated with distinct symptom clusters, aiming to elucidate the heterogeneity in PD and uncover the neural mechanisms underlying its motor and cognitive symptoms. Resting-state functional MRI (rs-fMRI) data from 55 non-demented PD patients and 24 healthy controls (HC) were used to perform seed-to-seed FC analyses. A clustering algorithm was applied to the cognitive and motor scores of all PD patients to generate relatively homogeneous symptomatic subgroups. PD patients exhibited a general decrease in FC within a network comprising the sensorimotor network (SMN) and the visual network (VN) regions. Symptom-based clustering revealed three relatively homogeneous subgroups, exhibiting a gradient pattern: patients with greater motor deficits showed significant disconnection within the SMN, whereas patients with greater visuospatial deficits exhibited reduced FC in an extended subnetwork, with pronounced disconnections between the VN and SMN areas. Our study demonstrated a notable disconnection between the SMN and VN, indicating impaired visual-motor integration in PD. Stronger disconnection within the SMN was associated with greater motor dysfunction, and stronger visual-sensorimotor disconnections were associated with greater visuospatial deficits. These findings suggest that at least two separate routes of functional disconnection may be responsible for the inhomogeneous symptom distribution in PD.
Cognitive reserve and aging: impacts on theory of mind and executive functions
(Routledge, 2025-03) Şandor, Serra; Hıdıroğlu Ongun, Ceren; Yıldırım, Elif
Aim: This study examines the effects of cognitive reserve (CR) on Executive Functions (EF) and Theory of Mind (ToM). While CR is suggested to mitigate age-related cognitive decline, its relationship with social cognition remains limited and inconsistent in the literature. It was hypothesized that the effect of CR on ToM might be indirect, mediated by EF and working memory. Methods: 225 cognitively healthy participants were included. CR was measured with the Cognitive Reserve Index Questionnaire, EF with verbal fluency and the Stroop Test, and WM using digit span tasks. Structural Equation Modeling was used to analyze the relationships among CR, EF, WM, and SC, controlling for age and gender. Results: CR was significantly associated with both RMET and FPRT performances. Mediation analysis revealed the direct effects of CR on RMET performance, while the effects on FPRT performance were mediated by executive functions. WM had a partial mediating effect on EF and ToM, but did not directly influence FPRT. Education was most strongly associated with RMET performance, while leisure activities were linked to FPRT performance. Conclusion: These findings suggest that CR indirectly supports ToM by enhancing EF and highlight the importance of interventions aimed at strengthening executive control to support social cognition in aging.
Treatment and long-term outcome of mental disorders: The grim picture from a quasi-epidemiological investigation in 54,826 subjects from 40 countries
(Elsevier Ireland Ltd, 2025-06) Fountoulakis, Konstantinos N.; Karakatsoulis, Gregory; Abraham, Seri; Adorjan, Kristina; Uddin Ahmed, Helal; Alarcòn, Renato Daniel; Arai, Kiyomi; Auwal, Sani Salihu; Berk, Michael; Levaj, Sarah; Yılmaz Kafalı, Helin
Introduction: This study registered rates of specific treatment options for mental disorders as well as their long-term outcome. Material and methods: The history of mental disorders was used as a proxy for diagnosis. The data came from the COMET-G study (40 countries; 54,826 subjects, 64.73 % females, 35.45±13.51 years old). The analysis included descriptive statistics, Risk Ratios, t-tests, and ANCOVA's. Results: 24.14 % reported a history of any mental disorder (depression >12 %, non-affective psychosis and Bipolar disorder 1 % each, >20 % self-injury, >10 % had attempted suicide, 7.17 % illegal substance abuse). Most patients were not under any kind of treatment (59.44 %) and most were not receiving treatment as recommended (e.g. 90 % of Bipolar and 2/3 of psychotic patients). No treatment at all and psychotherapy as monotherapy were consistently related to poorer outcomes. In anxiety or depression, only antidepressant monotherapy and benzodiazepines, in Bipolar disorder only antipsychotic monotherapy in males and antidepressant monotherapy in females and in non-affective psychosis antipsychotics and psychotherapy in females only, were related to good outcomes. No treatment modality was related to a good outcome in those with a history of self-harm, suicidal attempts, or illegal substance use. Only depression and treatment with antidepressants were related to metabolic syndrome. Discussion: In the community, the overwhelming majority of mental patients do not receive appropriate treatment or, even worse, no treatment at all. The outcome is unfavourable for the majority and only a few selective treatment options seem to make a difference.
Decision making, emotion recognition and childhood traumatic experiences in murder convicts ımprisoned with aggravated life sentence: a prison study
(Turkish Neuropsychiatric Society, 2025-03) Çıkrıkçılı, Uğur; Yıldırım, Elif; Buker, Seda; Ger, Can; Erözden, Ozan; Gürvit, Hakan; Saydam, Bilgin
Introduction: Decision-making and emotion recognition are two fundamental themes in social cognition. Disorders in these areas can lead to interpersonal, psychosocial, and legal problems for the individual and society. The likelihood of consequent aggression and crime makes them foci of forensic psychiatry over time. In this study, two developmental disorders that have a clear relationship with crime, that are antisocial personality disorder (ASPD), and psychopathy are investigated for their relationship with these social cognitive deficits.Methods: The present study involved 23 male prison inmates who were diagnosed with both antisocial personality disorder and psychopathy, as well as 23 control participants who were matched for age, gender, and level of education. Following the psychiatric interview, Reading the Mind in the Eyes Test (RMET), the Iowa Gambling Test (IGT), Toronto Alexithymia Scale (TAS), Defense Styles Questionnaire (DSQ), Childhood Psychic Trauma Scale (CTQ), Hare Psychopathy Checklist (PCL-R) were administered to all participants. Results: The results of the study showed that ASPD group performed statistically worse than healthy controls in TAS, CTQ, all items of DSQ, PCL-R Factor 1 and 2, and all the IGT scores (p<0.05). There were no statistically significant difference between in the RMET test performancesConclusion: These results suggest that ASPD and psychopathy lead to impaired decision-making behaviors due to the inability to recognize one’s own emotions and impulsivity, and that these characteristics play a critical role in the criminal behavior of individuals. In addition, contrary to expectations, the results of affective theory of mind assessed with the RMET showed similar characteristics in homicide convicts and healthy controls. These data indicate the need for further research in the field of forensic psychiatry.
Emotion dysregulation as a mediator between parental emotional availability and game addiction among Turkish late adolescents
(Routledge, 2025-02) Ülkümen, İpek; Aktan, Zekeriya Deniz
This study aimed to examine how difficulty in emotion regulation mediates the relationship between parental emotional availability and game addiction among Turkish late adolescents. 537 adolescents completed the Lum Emotional Availability of Parents, the Difficulties in Emotion Regulation Scale, Internet Gaming Disorder Short Form, and Sociodemographic Characteristics and Data Form. The results show that difficulty in emotion regulation fully mediates between parental emotional availability scores and adolescents’ game addiction scores. It can be concluded that interventions for the prevention and treatment of game addiction in late adolescents should focus on improving the parents’ emotional support and adolescents’ emotion regulation skills.
Turkish validity and reliability study of the childhood illness attitude scale
(Routledge, 2025-03) Aktan, Zekeriya Deniz; İnci İzmir, Sevim Berrin; Ünlü, Beyza; Yılmaz Kahraman, İpek Su
Severe forms of health anxiety cause serious dysfunction in people’s lives. Childhood Illness Attitude Scales (CIAS) is an assessment tool used to evaluate childhood health anxiety yet has not been validated for use in Turkey. The study aimed to examine the psychometric properties and factor structure of the Turkish version of the CIAS (CIAS-TR). The scale was administered to 306 children aged between 8 and 15 years. In addition to the CIAS-TR, participants were asked to complete the Screen for Child Anxiety-Related Emotional Disorders (SCARED) and the Pediatric Quality of Life Inventory (PedsQL). To measure test-retest reliability, CIAS-TR was completed by participants 15 days later. Results demonstrated good psychometric properties with high internal consistency and test-retest reliability. A positive correlation with SCARED and a negative correlation with PedsQL. Results from Confirmatory Factor Analysis suggested that a four-factor model best fit the data. The findings of the study indicate that the Turkish adaptation of the CIAS is an appropriate tool for assessing health anxiety in children.
Reliability of direct-to-home teleneuropsychological assessment: a within-subject design study
(Routledge, 2025-07-04) Yıldırım, Elif; Soncu Büyükişcan, Ezgi; Akça Kalem, Şükriye; Gürvit, Hakan
Objective: During the COVID-19 pandemic, the need to continue diagnosis and treatment processes, in addition to scientific research, led to a rapid shift towards direct-to-home tele-neuropsychology administrations, the reliability and validity of which had not been clearly established then. This study, therefore, aimed to examine the reliability of direct-to-home tele-neuropsychological assessment (TNP). Method: The sample included 105 cognitively healthy individuals aged between 50–83 years, and 47 patients diagnosed with neurocognitive disorders (mild cognitive impairment and early-stage Alzheimer’s type dementia). All participants underwent both face-to-face and teleneuropsychological assessments in a counterbalanced order. Results: The results revealed that performances across measures of attention, working memory, verbal fluency, verbal and visual memory, and visual perception were comparable across assessment modalities. Intraclass correlation coefficients of the tests ranged from.54 to.92. Conclusions: The findings of the study provide support for direct-to-home teleneuropsychological assessment among patients with neurocognitive disorders. Neuropsychological tests relying on verbal administration and independent of motor performance may represent a reliable alternative for this patient group when administered in settings where external distractions or technological limitations are controlled. For cognitively healthy individuals, on the other hand, the reliability of the TNP application is more questionable for memory and some executive function tests and therefore needs further exploration.
Do emotional demands and exhaustion affect work engagement? the mediating role of mindfulness
(Frontiers Media SA, 2024-1014) Karahan Kaplan, Merve; Bozkurt, Gözde; Aksu, Bumin Çağatay; Bozkurt, Serdar; Günsel, Ayşe; Gencer Çelik, Gülşah
Aim: The current paper seeks to elucidate the interrelationships among emotional demands (ED), emotional exhaustion (EE), mindfulness, and work engagement (WE), with an explanation of the mediating role of mindfulness within indicated relationships. Background: Nurses working in a stress-related environment face some emotional challenges. New methods such as mindfulness should be learned; therefore, positive outcomes occur along with new developments. Method: Responses were received from nurses through a self-report questionnaire using the convenience sample technique. Four hundred and twenty-nine nurses from health institutions in Istanbul participated in the study. The PLS-SEM technique was used to test the research model. Results: ED and mindfulness, EE and mindfulness, and mindfulness and WE relationships were found. While mindfulness was a mediator between EE and WE, it was not a mediator between ED and WE. Conclusion: It has been revealed that nurses cope with job-related challenges by being present at the moment with high awareness. Furthermore, mindful nurses also foster positive outcomes. Implications for nursing management: Precautions should be taken because of the nursing shortage. It is better to provide mindfulness training to nursing students in schools before their professional lives. Implementing and using technologies might be helpful for nurses.
Effects of o-tDCS and tDCS on maximal grip strength
(Istanbul University Press, 2024-10-14) Şeker, Sercan; Eskicioğlu, Gaye; Küçük, Zeynep; Karamürsel, Sacit
Objective: The aim of the current study was to examine and compare the effects of oscillatory transcranial direct current stimulation (o-tDCS) and transcranial direct current stimulation (tDCS) against sham stimulation on maximal intermittent gripping performance. Materials and Methods: The study included 25 healthy, right-handed male subjects (age range 18-35 years) who were randomly assigned to three separate groups: o-tDCS (n=9), tDCS (n=8) and sham (n=8). The left primary motor cortex was selected as the anodal stimulation region, and a cathode electrode was placed over the right supraorbital area. A hand dynamometer is used to measure the maximum grip values during a maximal intermittent gripping task. Between-group comparisons were made; for each stimulation group, baseline grip values of the participants were compared with those obtained during stimulation. Results: Although the o-tDCS group showed slightly better improvements in maximal and mean strength, there were no statistically significant differences between stimulation groups (p>0.05). Conclusion: The findings of the study suggest neither o-tDCS nor tDCS has a significant facilitative impact on grip strength values in healthy young males, most likely due to a ceiling effect in this population.
Analyzing language ability in first-episode psychosis and their unaffected siblings: a diffusion tensor imaging tract-based spatial statistics analysis study
(Elsevier Ltd, 2024-11) Çabuk, Tuğçe; Şahin Çevik, Didenur; Çakmak, Işık Batuhan; Yılmaz Kafalı, Helin; Şenol, Bedirhan; Avcı, Hanife; Karlı Oğuz, Kader; Toulopoulou, Timothea
Schizophrenia (SZ) is a highly heritable mental disorder, and language dysfunctions play a crucial role in diagnosing it. Although language-related symptoms such as disorganized speech were predicted by the polygenic risk for SZ which emphasized the common genetic liability for the disease, few studies investigated possible white matter integrity abnormalities in the language-related tracts in those at familial high-risk for SZ. Also, their results are not consistent. In this current study, we examined possible aberrations in language-related white matter tracts in patients with first-episode psychosis (FEP, N = 20), their siblings (SIB, N = 20), and healthy controls (CON, N = 20) by applying whole-brain Tract-Based Spatial Statistics and region-of-interest analyses. We also assessed language ability by Thought and Language Index (TLI) using Thematic Apperception Test (TAT) pictures and verbal fluency to see whether the scores of these language tests would predict the differences in these tracts. We found significant alterations in language-related tracts such as inferior longitudinal fasciculus (ILF) and uncinate fasciculus (UF) among three groups and between SIB and CON. We also proved partly their relationship with the language test as indicated by the significant correlation detected between TLI Impoverished thought/language sub-scale and ILF. We could not find any difference between FEP and CON. These results showed that the abnormalities, especially in the ILF and UF, could be important pathophysiological vulnerability indexes of schizophrenia. Further studies are required to understand better the role of language as a possible endophenotype in schizophrenia with larger samples.
The comparison of psychological factors and executive functions of children with Attention Deficit Hyperactivity Disorder and Cognitive Disengagement Syndrome to ADHD and ADHD comorbid with Oppositional Defiant Disorder
(SAGE Publications Inc., 2024-10) İnci İzmir, Sevim Berrin; Aktan, Zekeriya Deniz; Ercan, Eyüp Sabri
Objective: The study aims to examine family functionality, emotion regulation difficulties, preference for loneliness, social exclusion, internalizing and externalizing disorders, and executive functions in children with Attention Deficit Hyperactivity Disorder (ADHD) and Cognitive Disengagement Syndrome (CDS) and compare with ADHD, and ADHD+ Oppositional Defiant Disorder (ODD). Method: This study included 842 children aged 8–12 years. The subjects were categorized according to DSM-V as ADHD (n = 246), ADHD + ODD (n = 212), ADHD + CDS (n = 176), and Control group (n = 207). The solitude and social exclusion, difficulties in emotion dysregulation and Barkley SCT scales, Child Behavior Checklist, family assessment device, and Central Vital Signs (CNSVS) test were used. Results: According to the study, children with ADHD + CDS had higher rates of internalizing disorders. They also preferred being alone and experienced more difficulty communicating with their parents and solving problems within the family. Additionally, these children had difficulty recognizing and understanding the emotional reactions of others. The ADHD + ODD group presented a poorer performance on CNSVS domain tests except for the psychomotor speed test than other groups. Also, ADHD + CDS children had the lowest psychomotor speed scores and lower scores on reaction time and cognitive flexibility than pure ADHD children. Conclusion: This study will contribute to the etiology, treatment, and clinical discrimination of ADHD + CDS.
Benliğin ayrımlaşması ve bilişsel esnekliğin nevrotizm ile genel erteleme davranışı arasındaki sıralı aracılık etkisi: kesitsel bir çalışma
(Türkiye Klinikleri Yayınevi, 2024-09-18) Ünver, Buket; Anlar, Aslıhan
Amaç: Bu çalışmanın amacı, nevrotizmin genel erteleme davranışı ile ilişkisinde benliğin ayrımlaşması ve bilişsel esnekliğin sıralı aracılık etkisinin incelenmesidir. Gereç ve Yöntemler: Araştırma toplum örnekleminden 18-60 yaş arası (ortalama=31,6; standart sapma=11,2), 590 katılımcıdan (241 kadın, 348 erkek) oluşmaktadır. Araştırmada, kartopu ve uygun örnekleme yöntemleri kullanılmıştır. Veriler, Sosyodemografik Bilgi Formu, İş Stresi Bataryası-Nevrotizm Ölçeği, Erteleme Eğilimleri Ölçeği, Benliğin Ayrımlaşması Ölçeği, Bilişsel Esneklik Envanteri aracılığıyla çevrim içi olarak toplanmıştır. Araştırmada veri analizi için Pearson korelasyon analizi, bağımsız örneklem t-testi, varyans analizi ve sıralı aracılık etki analizleri kullanılmıştır. Bulgular: Araştırma sonuçları erteleme davranışı puanlarının erkeklerde kadınlara; bekârlarda evli olanlara ve çocuk sahibi olmayanların olanlara göre daha fazla olduğunu göstermektedir. Ayrıca 18-25 yaş aralığındaki bireylerin 26-39 yaş ve 40-60 yaş aralığındakilere göre daha fazla erteleme davranışları gösterdikleri bulgulanmıştır. Yapılan korelasyon analizinde, erteleme davranışı ile nevrotizm arasında pozitif yönde ilişki bulunmuştur. Benliğin ayrımlaşması ve bilişsel esneklik ile hem nevrotizm hem de erteleme arasında negatif yönde ilişki olduğu saptanmıştır. Aracı etki analiz sonuçlarında ise nevrotizmin ertelemeyi hem doğrudan hem de dolaylı olarak benliğin ayrımlaşması ile bilişsel esnekliğin sıralı aracılığında yordadığı görülmüştür. Sıralı aracılık analizi, erteleme davranışı söz konusu olduğunda benliğin ayrımlaşmasının ve duygusal düzenlemenin, bilişsel süreçlerin sağlıklı bir şekilde işleyebilmesi için bir ön koşul olduğunu ortaya koymaktadır. Sonuç: Bu çalışmanın bulguları, erteleme davranışına zemin hazırlayan duygusal ve bilişsel faktörlerin anlaşılmasına katkı sağlamaktadır. Bu bulgular, erteleme davranışıyla mücadele eden bireyler için psikoterapi çalışmalarında nevrotizm kişilik özelliklerinin, benliğin ayrımlaşması ve bilişsel esnekliğin ele alınmasının kritik bir öneme sahip olabileceğini ortaya koymaktadır.
Uzaktan nöropsikolojik değerlendirme: telenöropsikoloji
(BAYT Yayıncılık, 2024-05-25) Yıldırım, Elif; Soncu Büyükişcan, Ezgi; Akça Kalem, Şükriye; Gürvit, İ. Hakan
Amaç: Nöropsikolojik testlerin hastalara uzaktan, telefon ve videokonferans aracılığı ile yapılan uygulamalarını içeren telenöropsikoloji, uzakta yaşayan ya da hareket kısıtlılığı bulunan hastaların sağlık hizmetlerine ulaşım imkânını genişletebilmektedir. Covid-19 pandemisinin ortaya çıkması ile kognitif değerlendirmelerde telenöropsikoloji kullanımı önemli bir artış göstermiştir. Bu derlemede telenöropsikoloji ile ilgili yapılan çalışmaların sonuçlarının ve telenöropsikolojik değerlendirme ile ilgili temel esasların eleştirel bir şekilde gözden geçirilmesi amaçlanmıştır. Buna ek olarak, bu derlemede Türkiye uygulamaları için geliştirilmiş “ev temelli telenöropsikoloji uygulama rehberi” genel hatları ile paylaşılmıştır. Yöntem: Web of Science ve Pubmed veri tabanları kullanılarak konu ile ilgili erişilebilen tüm makale türlerini kapsayan bir şekilde literatür taraması yapılmıştır. Bulgular: Klinik temelli ve ev temelli telenöropsikolojik değerlendirme ile ilgili çalışmaların sonuçları dikkat, bellek, yürütücü işlevler ve dil gibi kognitif işlevleri değerlendiren ve özellikle sözel uygulamaya dayanan nöropsikolojik testlerin telenöropsikolojik değerlendirmede güvenilir bir şekilde uygulanabileceğini göstermektedir. Fakat telenöropsikolojik değerlendirmeye alınacak hastaların yönlendirilmesinde, değerlendirmede kullanılacak testlerin seçiminde ve etik konularda dikkat edilmesi gereken unsurlar bulunmaktadır. Buna ek olarak, telenöropsikolojik değerlendirmenin etkili bir şekilde yürütülmesi için görüşme öncesinde ve sırasında hem klinisyenin hem de hasta ve/veya hasta yakınının uygulanması önerilen adımların takip edilmesi önemlidir. Sonuç: Her ne kadar klinik nöropsikoloji pratiğinde hasta ile doğrudan temas kurmak önemli bir unsur olsa da gerekli durumlarda ve yetkin uzmanlar tarafından uygun uygulama prosedürleri takip edilerek yapılan telenöropsikolojik değerlendirmeler yüz yüze değerlendirmeler için iyi bir alternatif olabilir.
Psikolojik istismar ve sağlık davranışları arasında duygusal özerkliğin ve öz-şefkatin aracı rolü
(Erciyes Üniversitesi, 2024-12-27) Canbaz, Cansu; Ünver, Buket
Araştırmanın amacı ergenlerin ebeveynlerinden algıladıkları psikolojik istismar ve sağlıklı yaşam biçimi davranışları arasındaki ilişkide duygusal özerkliğin ve öz şefkatin aracı rolünü incelemektir. Çalışma kartopu ve uygun örnekleme yöntemleriyle 14-18 yaş aralığındaki 217 ergen ile gerçekleştirilmiştir. Çalışmanın veri toplama araçları sırasıyla; araştırmacılar tarafından hazırlanan Sosyodemografik Bilgi Formu, Psikolojik İstismar Ölçeği, Adolesan Yaşam Biçimi Ölçeği, Duygusal Özerklik Ölçeği ve Öz Şefkat Ölçeği Kısa Formu şeklindedir. Yapılan Spearman korelasyon analizi sonuçlarına göre mevcut çalışmanın tüm değişkenleri arasında anlamlı ilişkiler bulunmuştur. Yapılan aracı değişken analiz sonucuna göre ise duygusal özerkliğin ve öz şefkatin algılanan psikolojik istismar ve sağlıklı yaşam biçimi davranışları arasındaki ilişkide tam aracı bir etkiye sahip olduğu saptanmıştır. Bu çalışma, psikolojik istismarın olumsuz etkileriyle mücadelede duygusal özerklik ve öz şefkatin koruyucu rollerini ortaya koyarak, bu özelliklerin ergenlerin olumlu sağlık davranışlarına yönelmelerine olanak tanıdığını vurgulamaktadır. Sonuç olarak, bu çalışma ergenlerde psikolojik istismarın bireyin sağlıklı gelişimine yönelik etkilerini anlamada katkı sağlamakta ve koruyucu, önleyici müdahale programları için önemli ipuçları sunmaktadır.
Effects of early psychological trauma on limbic system structure and function
(Psikiyatride Güncel Yaklaşımlar, 2024-12-25) Kılıç, Bengü Sare Sevda Pelin; Saltoğlu, Seren; Erdoğdu, Emel
This paper aims to review the subtypes of childhood trauma and its effects on brain structures and function, especially the hippocampus and amygdala within the limbic system, in the context of clinical psychology. For this purpose, original articles published between 1996 and 2024 were systematically searched in major databases such as PubMed, PsycArticles, Web of Science, and Google Scholar using keywords such as early childhood trauma, psychological trauma, limbic system, hippocampus, amygdala, and neuroimaging. The articles were initially screened based on their titles, and those meeting the search criteria, including study population, investigated brain regions, and types of traumas, were further assessed for relevance. Ultimately, 136 articles were selected and discussed in this review. Trauma experiences in early life can have a significantly negative influence on a person's psychological health by causing neurodevelopmental impairments, especially in the limbic system. While it is understood that trauma influences how individuals think, behave, and feel, the results of neuroimaging studies reveal variations in the amygdala and hippocampus based on different trauma subtypes. These changes merit deeper investigation in future research to fully understand the reasons behind the diverse findings in existing literature.
Obsesif kompulsif bozuklukta göz-izleme teknolojisi kullanımı
(Işık Üniversitesi Yayınları, 2024-10-31) Okandan, Buse; Erdoğdu, Emel
Obsesif-kompulsif bozukluk (OKB), bireylerin iş, sosyal ve aile yaşantılarında ciddi problemlere yol açan, işlevselliklerini sınırlayan obsesyonlar ve kompulsiyonlarla karakterize edilen bir bozukluktur. OKB, psikolojik ve bedensel semptomlara ek olarak bilişsel işlevlerde de bozulmalara neden olabilmektedir. Bu bozuklukların temel nedenlerini anlamak ve uygun tedavi yöntemleri geliştirmek amacıyla kullanılan araştırma yöntemleri, teknolojinin ilerlemesiyle birlikte çeşitlenmektedir. Son yıllarda bilişsel işlevleri (dikkat, tepki ketleme, görsel-uzamsal yetenekler gibi ) incelemede etkili bir araç olarak görülen göz-izleme teknolojisi bu alanda giderek yaygınlaşmaktadır. Göz-izleme teknolojisi, göz konumu, hareketleri ve göz bebeği değişimlerini ölçme yeteneğine sahiptir. Bu çalışma, OKB’de göz-izleme yönteminin kullanımını ele alan güncel literatürdeki araştırmaları incelemektedir. 2010 ve Eylül 2024 tarihleri arasında yayınlanmış çalışmalara erişmek için Google Akademik, Pubmed, EBSCO EDS, Cambridge Journals gibi veri tabanlarında, Obsesif-Kompulsif Bozukluk, Eye-Tracking, Gözİzleme gibi terimler kullanılarak arama yapılmıştır. Derleme, göz izleme cihazları kullanarak OKB'de çeşitli bilişsel işlevleri ölçen 14 makaleyi içermektedir. Sonuçlar, göz-izleme teknolojisinin OKB’nin heterojen yapısına bağlı araştırma zorluklarını aşmada etkili olabileceğini, daha objektif veriler sağladığını ve geleneksel nöropsikolojik testlerle elde edilen bulguları desteklediğini göstermektedir.
Kişilerarası duygu düzenlemenin ve algılanan romantik ilişki kalitesinin psikolojik sıkıntı üzerindeki etkisi
(Manisa Celal Bayar Üniversitesi, 2025-03-26) Yılmaz, Simay; Yazıcı, Sena; Akçinar, Berna
Mevcut çalışmanın amacı, kişilerarası duygu düzenleme stratejilerinden yatıştırılma alt boyutunun ve algılanan romantik ilişki kalitesinin psikolojik sıkıntı üzerindeki etkilerini incelemektir. Araştırmaya, uygun örnekleme yöntemiyle seçilen 18-65 yaş arası, romantik ilişki içinde olan 230 yetişkin katılmıştır. Araştırmada “Kişilerarası Duygu Düzenleme Ölçeği”, “Algılanan Romantik İlişki Kalitesi Ölçeği” ve “Depresyon, Anksiyete ve Stres Ölçeği” kullanılmıştır. Çalışmanın sonuçlarına göre yatıştırılma stratejisinin kullanım düzeyi psikolojik sıkıntı düzeyini anlamlı ve pozitif yönde [F(1, 229) = 5.49, ß= .15, p<.05]; algılanan romantik ilişki kalitesi düzeyi psikolojik sıkıntı düzeyini anlamlı ve negatif yönde (F(1, 229) = 14.60, ß= -.25, p<.001) yordamaktadır; yatıştırılma düzeyi, algılanan romantik ilişki kalitesi düzeyini istatistiksel olarak anlamlı şekilde yordamamaktadır [F(1, 229) = 0.55, ß= .05, p = .461]. Aracılık analizi sonuçları, algılanan romantik ilişki kalitesinin yatıştırılma ile psikolojik sıkıntı arasındaki ilişkide anlamlı bir aracılık etkisi olmadığını göstermektedir (b= -.0124, SH=.0191, %95 GA[-.0536, .0228]). Çalışmanın bulgularının terapistlere bireylerin duygu düzenleme stratejilerini iyileştirme ve psikolojik sıkıntısını azaltma konusunda yol gösterebileceği düşünülmektedir.
Healthy lifestyle behaviors of university students: the role of sense of coherence and family health climate
(Dokuz Eylul University, 2025-01-31) Cerrahoğlu, Ece; Ünver, Buket; Ülkümen, İpek
Purpose: This study aims to examine the predictive role of individual sense of coherence, family sense of coherence and family health climate variables on university students' healthy lifestyle behaviors. Material and Methods: The sample of the study consisted of 371 university students aged 18-25. Sociodemographic Information Form, Healthy Lifestyle Behaviors Scale, Sense of Coherence Scale, Family Sense of Coherence Scale, Family Health Climate Scale were applied to the participants in order to collect the research data. Correlation analysis, independent two-sample t-test, one-way ANOVA test and multiple linear regression analysis were used to analyze the data. Results: According to the results of correlation analysis, a positive relationship was found between healthy lifestyle behaviors and individual sense of coherence, family sense of coherence and family health climate (p<.05). As a result of the multiple linear hierarchical regression analysis, after controlling for the sex variable, individual sense of coherence and family health climate variables significantly predicted healthy lifestyle behaviors (p<.05), while family sense of coherence had no significant predictive role on healthy lifestyle behaviors (p>.05). Conclusion: The findings show that individual sense of coherence, family sense of coherence and family health climate variables are essential on university students' healthy lifestyle behaviors. The sense of coherence provides significant protection in adopting health behaviors that will determine future health and well-being. Similarly, increasing healthy living practices within the family is of great importance for young people to adopt healthy lifestyle behaviors.
Assessing the mediating relationships between psychological factors in children with attention deficit hyperactivity disorder and cognitive disengagement syndrome
(Routledge Journals, Taylor & Francis Ltd, 2024-04) İnci İzmir, Sevim Berrin; Aktan, Zekeriya Deniz; Ercan, Eyüp Sabri
This study aims to investigate the predictive and mediating relationships between emotion dysregulation, internalizing disorders, family functionality, loneliness preference, and executive functions (EF) in children with attention deficit hyperactivity disorder and cognitive disengagement syndrome (ADHD + CDS). This study included 176 children and adolescents (92 boys, 84 girls) who were diagnosed with ADHD + CDS according to the Diagnostic and Statistical Manual of Mental Disorders, the Fifth Edition criteria by a fellowship-trained child and adolescent psychiatrist, between ages 8 -12 (M = 10, SD = 1.52) with a convenience sampling method. The solitude scale for children, difficulties in emotion dysregulation scale, Child Behavior Checklist, Barkley Sluggish Cognitive Tempo Scale, Family assessment device, and CNS Vital Signs test were used. The results showed that difficulty in emotion regulation, preference for loneliness, internalizing disorders and CDS symptom severity did not have a mediating effect between family functionality and EF. Still, emotion dysregulation mediates the relationship between EF and internalizing disorders by itself and through loneliness preference. Also, preference for loneliness and emotion dysregulation had a mediating effect between family functionality and internalizing disorders. Finally, it was found that the effect of emotion regulation difficulty, loneliness preference, and internalizing disorders had a mediating role between CDS symptom severity and family functionality. In conclusion, the information obtained from this study on the etiology of CDS may guide future studies.

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