The effect of SARS-CoV-2 virus on resting-state functional connectivity during adolescence: Investigating brain correlates of psychotic-like experiences and SARS-CoV-2 related inflammation response
Yükleniyor...
Tarih
2023-12
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We first aimed to investigate resting-state functional connectivity (rs-FC) differences between adolescents exposed to SARS-CoV-2 and healthy controls. Secondly, the moderator effect of PLEs on group differences in rs-FC was examined. Thirdly, brain correlates of inflammation response during acute SARS-CoV-2 infection were investigated. Eighty-two participants aged between 14 and 24 years (SARS-CoV-2 (n = 35), controls (n = 47)) were examined using rs-fMRI. Seed-based rs-FC analysis was performed. The positive subscale of Community Assessment of Psychotic Experiences-42 (CAPE-Pos) was used to measure PLEs. The SARS-CoV-2 group had a lesser rs-FC within sensorimotor network (SMN), central executive network (CEN) and language network (LN), but an increased rs-FC within visual network (VN) compared to controls. No significant differences were detected between the groups regarding CAPE-Pos-score. However, including CAPE-Pos as a covariate, we found increased rs-FC within CEN and SN in SARS-CoV-2 compared to controls. Among the SARS-CoV-2 group, neutrophil/lymphocyte and thrombocyte*neutrophil/lymphocyte ratio was correlated with decreased/increased FC within DMN and SN, and increased FC within CEN. Our results showed rs-FC alterations within the SMN, CEN, LN, and VN among adolescents exposed to SARS-CoV-2. Moreover, changes in rs-FC associated with PLEs existed in these adolescents despite the absence of clinical changes. Furthermore, inflammation response was correlated with alterations in FC within the triple network system.
Açıklama
This work was supported by The Scientific and Technological Research Council of Turkey (TÜBİTAK) (Grant Number: 120K729 ) to TT.
Anahtar Kelimeler
Adolescent, Brain networks, COVID-19, Functional connectivity, Inflammation markers, Neuroimaging, Psychosis proneness
Kaynak
Psychiatry Research - Neuroimaging
WoS Q Değeri
Q3
Q3
Q3
Scopus Q Değeri
Q1
Cilt
336
Sayı
Künye
Yılmaz Kafalı, H., Daşgın, H., Şahin Çevik, D., Sozan, S. S., Oğuz, K. K., Mutlu, M., Özkaya Parlakay, A. & Toulopoulou, T. (2023). The effect of SARS-CoV-2 virus on resting-state functional connectivity during adolescence: Investigating brain correlates of psychotic-like experiences and SARS-CoV-2 related inflammation response. Psychiatry Research - Neuroimaging, 336, 1-8. doi:10.1016/j.pscychresns.2023.111746
