Paraoxonase (PON1) L55M and Q192R polymorphisms in major depressive disorder and bipolar disorder

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dc.authorid0000-0002-6965-370X
dc.authorid0009-0001-3125-8288
dc.authorid0000-0003-4266-393X
dc.authorid0000-0001-7599-5821
dc.authorid0000-0002-1322-2716
dc.contributor.authorYıldız, Mesuten_US
dc.contributor.authorÇam Çelikel, Feryalen_US
dc.contributor.authorAteş, Ömeren_US
dc.contributor.authorErdoğan Taycan, Serapen_US
dc.contributor.authorBenli, İsmailen_US
dc.contributor.authorDemir, Osmanen_US
dc.date.accessioned2019-08-01T12:10:23Z
dc.date.accessioned2019-08-05T16:08:59Z
dc.date.available2019-08-01T12:10:23Z
dc.date.available2019-08-05T16:08:59Z
dc.date.issued2017
dc.departmentIşık Üniversitesi, Fen Edebiyat Fakültesi, Psikoloji Bölümüen_US
dc.departmentIşık University, Faculty of Arts and Sciences, Department of Psychologyen_US
dc.description.abstractObjective: Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depressive disorder and bipolar disorder. The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depressive disorder and bipolar disorder. Methods: PON1 L55M and Q192R single nucleotide polymorphisms were analyzed in a group consisted of 100 patients with major depressive disorder, and 100 patients with bipolar disorder and 96 healthy controls. Polymorphisms were analyzed by using polymerase chain reaction. Results: There were no statistically significant differences between groups for the existence of PON1 genotypes. Additionally, there was no association between the PON1 genotypes and disease variables in both depressed and bipolar patients. Conclusions: Evaluating the different stages of patients with mood disorders and examining the connection between PON1 polymorphisms and treatment outcomes will help us to clarify the relationship between PON1 and mood disorders.en_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationYildiz, M., Cam, F.C., Ates, O., Erdogan S.T., Benli, I., Demir, O., (2017). Paraoxonase (PON1) L55M and Q192R Polymorphisms in Major Depressive Disorder and Bipolar Disorder. Journal of Mood Disorders, 7(2), 86-92. doi:10.5455/jmood.20170304070525en_US
dc.identifier.endpage92
dc.identifier.issn2146-1473
dc.identifier.issue2
dc.identifier.startpage86
dc.identifier.urihttps://hdl.handle.net/11729/2137
dc.identifier.urihttp://dx.doi.org/10.5455/jmood.20170304070525
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/253306
dc.identifier.volume7
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorÇam Çelikel, Feryalen_US
dc.institutionauthorid0009-0001-3125-8288
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherPsikofarmakoloji Derneği adına Mesut Çetinen_US
dc.relation.journalJournal of Mood Disordersen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPsikiyatrien_US
dc.subjectAssociation studyen_US
dc.subjectBipolar disorderen_US
dc.subjectDepressionen_US
dc.subjectParaoxonase (PON1)en_US
dc.subjectPolymorphismen_US
dc.titleParaoxonase (PON1) L55M and Q192R polymorphisms in major depressive disorder and bipolar disorderen_US
dc.typeArticleen_US
dspace.entity.typePublication

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