Paraoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder

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dc.contributor.authorYıldız, Mesuten_US
dc.contributor.authorÇam Çelikel, Feryalen_US
dc.contributor.authorAteş, Ömeren_US
dc.contributor.authorErdoğan Taycan, Serapen_US
dc.contributor.authorBenli, İsmailen_US
dc.contributor.authorDemir, Osmanen_US
dc.date.accessioned2019-03-25T23:24:39Z
dc.date.available2019-03-25T23:24:39Z
dc.date.issued2017-05/06
dc.departmentIşık Üniversitesi, Fen Edebiyat Fakültesi, Psikoloji Bölümüen_US
dc.departmentIşık University, Faculty of Arts and Sciences, Department of Psychologyen_US
dc.description.abstractBackground: Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depression and bipolar disorder. Objective: The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depression and bipolar affective disorder. Methods: PON1 L55M and Q192R single nucleotide polymorphisms were analyzed in a group consisted of 100 patients with major depression, and 100 patients with bipolar affective disorder and 96 healthy controls. Polymorphisms were analyzed by using polymerase chain reaction. Results: Our findings reported no association between Q192R and L55M polymorphisms of PON1 and major depression and bipolar disorder. Additionally, there was no association between the PON1 genotypes and disease variables in both depressed and bipolar patients. Discussion: Evaluating the different stages of patients with affective disorders and and investigating the connection between PON1 polymorphisms and treatment outcomes will help us to clarify the relationship between PON1 and mood disorders.en_US
dc.description.sponsorshipThis study was supported by the Gaziosmanpasa University (project no: 2015/28). The authors would like to thank the patients and the controls for their participationen_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationYildiz, M., Celikel, F., Ates, O., Taycan, S., Benli, I., & Demir, O. (2017). Paraoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder. Archives of Clinical Psychiatry, 44(3), 73-76. doi:10.1590/0101-60830000000123en_US
dc.identifier.doi10.1590/0101-60830000000123
dc.identifier.endpage76
dc.identifier.issn0101-6083en_US
dc.identifier.issn1806-938Xen_US
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85026478189en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage73
dc.identifier.urihttps://hdl.handle.net/11729/1496
dc.identifier.urihttp://dx.doi.org/10.1590/0101-60830000000123
dc.identifier.volume44
dc.identifier.wosWOS:000405461800005en_US
dc.identifier.wosqualityQ4
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakScience Citation Index Expanded (SCI-EXPANDED)en_US
dc.institutionauthorÇam Çelikel, Feryalen_US
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherUniv Sao Pauloen_US
dc.relation.ispartofArchives of Clinical Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMajor depressionen_US
dc.subjectBipolar affective disorderen_US
dc.subjectParaoxonase (PON1)en_US
dc.subjectPolymorphismen_US
dc.subjectAssociation studyen_US
dc.subjectGenome-wide associationen_US
dc.subjectSerum paraoxonaseen_US
dc.subject(Pon)1 activityen_US
dc.subjectArylesteraseen_US
dc.subjectGeneen_US
dc.subjectPopulationen_US
dc.subjectStressen_US
dc.subjectHealthen_US
dc.subjectRisken_US
dc.titleParaoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorderen_US
dc.typeArticleen_US
dspace.entity.typePublication

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