The comparison of functional connectivity in Parkinson’s Disease patients with and without Parkin gene mutations

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dc.authorid0000-0002-2773-0367
dc.authorid0000-0001-7896-3681
dc.authorid0000-0001-6625-6787
dc.authorid0000-0002-2817-5596
dc.authorid0000-0001-8413-6949
dc.authorid0000-0002-2035-4338
dc.authorid0000-0001-6989-8611
dc.authorid0000-0003-0667-2329
dc.authorid0000-0001-6032-0856
dc.authorid0000-0002-6803-734X
dc.authorid0000-0002-4624-4428
dc.contributor.authorÇebi, Merveen_US
dc.contributor.authorAy, Ulaşen_US
dc.contributor.authorKıçik, Anien_US
dc.contributor.authorErdoğdu, Emelen_US
dc.contributor.authorTepgeç, Fatihen_US
dc.contributor.authorUyguner, Zehra Oyaen_US
dc.contributor.authorTüfekçioğlu, Zeynepen_US
dc.contributor.authorSamancı, Bediaen_US
dc.contributor.authorBilgiç, Başaren_US
dc.contributor.authorEmre, Muraten_US
dc.contributor.authorDemiralp, Tameren_US
dc.contributor.authorHanağası, Haşmet Ayhanen_US
dc.date.accessioned2025-09-12T11:29:11Z
dc.date.available2025-09-12T11:29:11Z
dc.date.issued2025-06-19
dc.departmentIşık Üniversitesi, İktisadi, İdari ve Sosyal Bilimler Fakültesi, Psikoloji Bölümüen_US
dc.departmentIşık University, Faculty of Economics, Administrative and Social Sciences, Department of Psychologyen_US
dc.descriptionThis study was supported by Istanbul University Research Projects Unit with project numbers 21534 and TSA-2022-39128.en_US
dc.description.abstractIntroduction: Mapping the functional connectivity of brain regions became appealing in recent research in neurology. Accordingly, a growing body of evidence shows resting-state functional connectivity (rsFC) changes in neurodegenerative disorders including Parkinson’s Disease (PD). As characterised by extensive and progressive dopaminergic loss in the substantia nigra, PD emerges with serious motor and non-motor dysfunctions. In the literature, the minority of PD cases have been associated with certain genetic mutations. The aim of this study was to investigate the rsFC in a group of PD patients having Parkin gene mutation. Method: Twelve PD patients with Parkin mutation (PP-PD), 12 PD patients without Parkin mutation (PN-PD) and 12 healthy controls (HC) were included in the study. All participants underwent a resting-state functional magnetic resonance imaging as well as a neuropsychological assessment and clinical examination. Results: Results indicated that PP-PD had longer disease duration, a higher rate of dyskinesia and lower scores on complex visual perception tests. The resting state networks showed that all PD (consisting of PP-PD and PN-PD) and PP-PD groups had increased functional connectivity in the frontoparietal network as compared to the HC. In addition, the PP-PD group displayed decreased functional connectivity in the dorsal attention network compared to the PN-PD. Conclusion: In conclusion, our data suggests that PD with Parkin gene mutation might be emerging with distinct resting state functional connectivity changes in the brain.en_US
dc.description.sponsorshipİstanbul Üniversitesien_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationÇebi, M., Ay, U., Kıçik, A., Erdoğdu, E., Tepgeç, F., Uyguner, Z. O., Tüfekçioğlu, Z., Samancı, B., Bilgiç, B., Emre, M., Demiralp, T. & Hanağası, H. A. (2025). The comparison of functional connectivity in Parkinson’s Disease patients with and without Parkin gene mutations. Noropsikiyatri Arsivi, 62(2), 131-135. doi:https://doi.org/10.29399/npa.28719en_US
dc.identifier.doi10.29399/npa.28719
dc.identifier.endpage135
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue2
dc.identifier.pmid40583943
dc.identifier.scopus2-s2.0-105009358105
dc.identifier.scopusqualityQ3
dc.identifier.startpage131
dc.identifier.urihttps://hdl.handle.net/11729/6698
dc.identifier.urihttps://doi.org/10.29399/npa.28719
dc.identifier.volume62
dc.identifier.wosWOS:001530458000006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScience Citation Index Expanded (SCI-EXPANDED)en_US
dc.institutionauthorErdoğdu, Emelen_US
dc.institutionauthorid0000-0002-2817-5596
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherTurkish Neuropsychiatric Societyen_US
dc.relation.ispartofNoropsikiyatri Arsivien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFunctional connectivityen_US
dc.subjectFunctional magnetic resonance imagingen_US
dc.subjectIndependent component analysisen_US
dc.subjectParkinen_US
dc.subjectParkinson’s Diseaseen_US
dc.subjectAlpha synucleinen_US
dc.subjectChromosome proteinen_US
dc.subjectCyclin G associated kinaseen_US
dc.subjectGlucosylceramidaseen_US
dc.subjectLeucine rich repeat kinase 2en_US
dc.subjectLysosome associated membrane protein 1en_US
dc.subjectParkinson disease associated proteinen_US
dc.subjectPhosphatidylinositol 3en_US
dc.subject4en_US
dc.subject5 trisphosphate 3 phosphataseen_US
dc.subjectProtein deglycase DJ-1en_US
dc.subjectTau proteinen_US
dc.subjectUbiquitin carboxyl terminal hydrolase CYLDen_US
dc.subjectUnclassified drugen_US
dc.subjectAddenbrooke cognitive examination reviseden_US
dc.subjectAdulten_US
dc.subjectArticleen_US
dc.subjectBlood samplingen_US
dc.subjectBrain sizeen_US
dc.subjectClinical articleen_US
dc.subjectClinical examinationen_US
dc.subjectCognitionen_US
dc.subjectCognitive defecten_US
dc.subjectComparative studyen_US
dc.subjectDisease durationen_US
dc.subjectDisease severityen_US
dc.subjectFemaleen_US
dc.subjectFollow upen_US
dc.subjectFrontoparietal networken_US
dc.subjectGene mutationen_US
dc.subjectGenetic susceptibilityen_US
dc.subjectHamilton depression rating scaleen_US
dc.subjectHigh throughput sequencingen_US
dc.subjectHumanen_US
dc.subjectJudgement line orientation testen_US
dc.subjectMaleen_US
dc.subjectMethylation-specific multiplex ligation-dependent probe amplificationen_US
dc.subjectMiddle ageden_US
dc.subjectMini mental state examinationen_US
dc.subjectMovement perceptionen_US
dc.subjectNeuroimagingen_US
dc.subjectNeuropsychological assessmenten_US
dc.subjectNuclear magnetic resonance imagingen_US
dc.subjectParkinson diseaseen_US
dc.subjectParkinsonismen_US
dc.subjectPrincipal component analysisen_US
dc.subjectRepetition timeen_US
dc.subjectStroop interference timeen_US
dc.subjectSymbol digit modalities testen_US
dc.subjectT1 weighted imagingen_US
dc.subjectTremoren_US
dc.subjectUnified Parkinson disease rating scaleen_US
dc.subjectVisual perception testen_US
dc.subjectWisconsin card sorting testen_US
dc.subjectRobusten_US
dc.subjectOptimizationen_US
dc.subjectRegistrationen_US
dc.subjectNetworksen_US
dc.subjectCarriersen_US
dc.titleThe comparison of functional connectivity in Parkinson’s Disease patients with and without Parkin gene mutationsen_US
dc.title.alternativeParkin gen mutasyonu olan ve olmayan Parkinson hastalarında fonksiyonel bağlantısallığın karşılaştırılmasıen_US
dc.typeArticleen_US
dspace.entity.typePublicationen_US

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