Eco-friendly bacterial cellulose/castor oil hydrogels: physicochemical behavior and biocompatibility

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dc.authorid0000-0002-2636-1467
dc.authorid0000-0001-9133-3502
dc.authorid0000-0002-7511-3355
dc.authorid0000-0002-3395-5642
dc.authorid0000-0002-0764-8876
dc.authorid0000-0002-3806-7118
dc.contributor.authorIşıkçı Koca, Elifen_US
dc.contributor.authorPınar, Orkunen_US
dc.contributor.authorYalçın Çapan, Özlemen_US
dc.contributor.authorÇaylı, Gökhanen_US
dc.contributor.authorKazan, Dileken_US
dc.contributor.authorÇakır Hatır, Pınaren_US
dc.date.accessioned2025-10-30T07:13:09Z
dc.date.available2025-10-30T07:13:09Z
dc.date.issued2025-10-27
dc.departmentIşık Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Elektrik-Elektronik Mühendisliği Bölümüen_US
dc.departmentIşık University, Faculty of Engineering and Natural Sciences, Department of Electrical-Electronics Engineeringen_US
dc.description.abstractIn the present work, novel thermoresponsive hydrogels were developed from renewable resources, and the influence of bacterial cellulose molar ratio on their chemical structure, thermal properties, swelling behavior, morphology, and biocompatibility was systematically investigated. The hydrogels were fabricated using castor oil, 4,4'-diphenylmethane diisocyanate, bacterial cellulose, Nisopropylacrylamide, and N,N'-Methylenebisacrylamide. Structural and physicochemical characterizations were performed by Fourier-transform infrared spectroscopy, scanning electron microscopy, differential scanning calorimetry, and thermogravimetric analysis. The highest equilibrated swelling degree was achieved as 592.6% at the maximum bacterial cellulose content. SEM images revealed that the formation of spongy architecture is caused by the increase in the bacterial cellulose content. In vitro biocompatibility studies revealed that the hydrogel with the highest bacterial cellulose content exhibited the greatest cytocompatibility, with an IC50 value of 11.16 mg/ml. Overall, the findings demonstrate the successful fabrication of a novel bio-based thermoresponsive hydrogel through an eco-friendly approach, highlighting its potential for diverse biomedical applications.en_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationIşıkçı Koca, E., Pınar, O., Yalçın Çapan, Ö., Çaylı, G., Kazan, D. & Çakır Hatır, P. (2025). Eco-friendly Bacterial Cellulose/Castor Oil Hydrogels: Physicochemical Behavior and Biocompatibility. Sakarya University Journal of Science, 29(5), 498-509. https://doi.org/10.16984/saufenbilder.1702047en_US
dc.identifier.doi10.16984/saufenbilder.1702047
dc.identifier.endpage509
dc.identifier.issn2147-835X
dc.identifier.issn1301-4048
dc.identifier.issue5
dc.identifier.scopus2-s2.0-105022451324
dc.identifier.scopusqualityQ3
dc.identifier.startpage498
dc.identifier.urihttps://hdl.handle.net/11729/6771
dc.identifier.urihttps://doi.org/10.16984/saufenbilder.1702047
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1356040
dc.identifier.volume29
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorIşıkçı Koca, Elifen_US
dc.institutionauthorid0000-0002-2636-1467
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherSakarya Universityen_US
dc.relation.ispartofSakarya University Journal of Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBacterial celluloseen_US
dc.subjectCastor oilen_US
dc.subjectHydrogelsen_US
dc.subjectBiocompatibilityen_US
dc.subjectEco-friendly processesen_US
dc.titleEco-friendly bacterial cellulose/castor oil hydrogels: physicochemical behavior and biocompatibilityen_US
dc.typeArticleen_US
dspace.entity.typePublicationen_US

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