Monitoring small molecule diffusion into hydrogels at various temperatures by fluorescence technique
Yükleniyor...
Dosyalar
Tarih
2006-12-01
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier B.V.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
steady state fluorescence technique was used to study small molecule diffusion into polyacrylamide (PAAm) gels at various temperatures. Pyranine (P-y), dissolved in water was introduced as a probe and fluorescence emission (I-p) from Py was monitored during diffusion. Scattered light intensities, I-sc from PAAm gel was also monitored to observe structural variations during diffusion process. Increase in I-P intensity was attributed to P-Y diffusion into PAAm get. On the other hand decrease in I-sc intensity was interpreted as the variation of the spatial heterogeneities in the system. Li-Tanaka and Fickian models were used to quantify the swelling and diffusion experiments and diffusion coefficients were produced in both cases. Related activation energies were also calculated from the corresponding physical processes.
Açıklama
Anahtar Kelimeler
Diffusion, Hydrogel, Fluorescence, Temperatures, Photon transmission technique, Polyacrylamide gels, Phase-transition, Real-time, Kinetics, Collapse, Release, Biophysics, Chemistry, Pharmaceutical, Gels, Models, Statistical, Particle size, Solubility, Spectrometry, Fluorescence, Water, Diffusion coefficient, Light scattering, Priority journal, Steady state
Kaynak
International Journal of Pharmaceutics
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
326
Sayı
1-2
Künye
Evingür, G. A., Karslı, K. & Pekcan, M. Ö. (2006). Monitoring small molecule diffusion into hydrogels at various temperatures by fluorescence technique. International Journal of Pharmaceutics, 326(1-2), 7-12. doi:10.1016/j.ijpharm.2006.06.043
