Monitoring small molecule diffusion into hydrogels at various temperatures by fluorescence technique

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dc.authorid0000-0003-2210-5842
dc.authorid0000-0002-0082-8209
dc.contributor.authorEvingür, Gülşen Akınen_US
dc.contributor.authorKarslı, Kadiren_US
dc.contributor.authorPekcan, Mehmet Önderen_US
dc.date.accessioned2015-01-15T23:00:33Z
dc.date.available2015-01-15T23:00:33Z
dc.date.issued2006-12-01
dc.departmentIşık Üniversitesi, Fen Edebiyat Fakültesi, Fizik Bölümüen_US
dc.departmentIşık University, Faculty of Arts and Sciences, Department of Physicsen_US
dc.description.abstractsteady state fluorescence technique was used to study small molecule diffusion into polyacrylamide (PAAm) gels at various temperatures. Pyranine (P-y), dissolved in water was introduced as a probe and fluorescence emission (I-p) from Py was monitored during diffusion. Scattered light intensities, I-sc from PAAm gel was also monitored to observe structural variations during diffusion process. Increase in I-P intensity was attributed to P-Y diffusion into PAAm get. On the other hand decrease in I-sc intensity was interpreted as the variation of the spatial heterogeneities in the system. Li-Tanaka and Fickian models were used to quantify the swelling and diffusion experiments and diffusion coefficients were produced in both cases. Related activation energies were also calculated from the corresponding physical processes.en_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationEvingür, G. A., Karslı, K. & Pekcan, M. Ö. (2006). Monitoring small molecule diffusion into hydrogels at various temperatures by fluorescence technique. International Journal of Pharmaceutics, 326(1-2), 7-12. doi:10.1016/j.ijpharm.2006.06.043en_US
dc.identifier.doi10.1016/j.ijpharm.2006.06.043
dc.identifier.endpage12
dc.identifier.issn0378-5173
dc.identifier.issn1873-3476
dc.identifier.issue1-2
dc.identifier.pmid16889915
dc.identifier.scopus2-s2.0-33750461231
dc.identifier.scopusqualityQ1
dc.identifier.startpage7
dc.identifier.urihttps://hdl.handle.net/11729/201
dc.identifier.urihttp://dx.doi.org/10.1016/j.ijpharm.2006.06.043
dc.identifier.volume326
dc.identifier.wosWOS:000242257500002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScience Citation Index Expanded (SCI-EXPANDED)en_US
dc.institutionauthorPekcan, Mehmet Önderen_US
dc.institutionauthorid0000-0002-0082-8209
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofInternational Journal of Pharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiffusionen_US
dc.subjectHydrogelen_US
dc.subjectFluorescenceen_US
dc.subjectTemperaturesen_US
dc.subjectPhoton transmission techniqueen_US
dc.subjectPolyacrylamide gelsen_US
dc.subjectPhase-transitionen_US
dc.subjectReal-timeen_US
dc.subjectKineticsen_US
dc.subjectCollapseen_US
dc.subjectReleaseen_US
dc.subjectBiophysicsen_US
dc.subjectChemistry, Pharmaceuticalen_US
dc.subjectGelsen_US
dc.subjectModelsen_US
dc.subjectStatisticalen_US
dc.subjectParticle sizeen_US
dc.subjectSolubilityen_US
dc.subjectSpectrometry, Fluorescenceen_US
dc.subjectWateren_US
dc.subjectDiffusion coefficienten_US
dc.subjectLight scatteringen_US
dc.subjectPriority journalen_US
dc.subjectSteady stateen_US
dc.titleMonitoring small molecule diffusion into hydrogels at various temperatures by fluorescence techniqueen_US
dc.typeArticleen_US
dspace.entity.typePublication

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