Elevated sTREM2 and NFL levels in patients with sepsis associated encephalopathy

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dc.authorid0000-0003-0173-3604
dc.authorid0000-0003-4419-4903
dc.authorid0000-0002-4809-2966
dc.authorid0000-0002-5599-4917
dc.authorid0000-0002-9593-7394
dc.authorid0000-0003-3445-9197
dc.authorid0000-0003-2908-8475
dc.authorid0000-0001-7986-4984
dc.authorid0000-0002-3942-093X
dc.authorid0000-0002-4749-1471
dc.authorid0000-0002-4483-0394
dc.contributor.authorOrhun, Günselien_US
dc.contributor.authorEsen, Figenen_US
dc.contributor.authorYılmaz, Vuslaten_US
dc.contributor.authorUlusoy, Cananen_US
dc.contributor.authorŞanlı, Elifen_US
dc.contributor.authorYıldırım, Elifen_US
dc.contributor.authorGürvit, İbrahim Hakanen_US
dc.contributor.authorErgin Özcan, Perihanen_US
dc.contributor.authorSencer, Serraen_US
dc.contributor.authorBebek, Nersesen_US
dc.contributor.authorTüzün, Erdemen_US
dc.date.accessioned2021-05-18T10:55:10Z
dc.date.available2021-05-18T10:55:10Z
dc.date.issued2023-03-04
dc.departmentIşık Üniversitesi, Fen Edebiyat Fakültesi, Psikoloji Bölümüen_US
dc.departmentIşık University, Faculty of Arts and Sciences, Department of Psychologyen_US
dc.descriptionThis work was supported by the Scientific Research Projects Coordination Unit of Istanbul University under Grant [35165].en_US
dc.description.abstractPurpose: Sepsis-associated encephalopathy (SAE) is a common manifestation of sepsis that may lead to cognitive decline. Our aim was to investigate whether the neurofilament light chain (NFL) and soluble triggering receptor expressed on myeloid cells 2 (sTREM2) could be utilized as prognostic biomarkers in SAE. Materials and methods: In this prospective observational study, baseline serum levels of sTREM2 and cerebrospinal fluid (CSF) levels of sTREM2 and NFL were measured by ELISA in 11 SAE patients and controls. Patients underwent daily neurological examination. Brain magnetic resonance imaging (MRI) and standard electroencephalography (EEG) were performed. Cognitive dysfunction was longitudinally assessed after discharge in 4 SAE patients using the Mini-Mental State Examination (MMSE) and Addenbrooke’s Cognitive Examination-Revised (ACE-R) tests. Results: SAE patients showed higher CSF sTREM2 and NFL levels than controls. sTREM2 and NFL levels were not correlated with the severity measures of sepsis. Three months after discharge, 2 SAE patients displayed ACE-R scores congruent with mild cognitive impairment (MCI), persisting in one patient 12 months after discharge. SAE patients with MCI showed higher CSF NFL levels, bacteremia, and abnormal brain MRI. Patients with increased serum/CSF sTREM2 levels showed trends towards displaying poorer attention/orientation and visuo-spatial skills. Conclusions: sTREM2 and NFL levels may serve as a prognostic biomarker for cognitive decline in SAE. These results lend further support for the involvement of glial activation and neuroaxonal degeneration in the physiopathology of SAE.en_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationOrhun, G., Esen, F., Yılmaz, V., Ulusoy, C., Şanlı, E., Yıldırım, E., Gürvit, İ. H., Ergin Özcan, P., Sencer, S., Bebek, N. & Tüzün, E. (2023). Elevated sTREM2 and NFL levels in patients with sepsis associated encephalopathy. International Journal of Neuroscience, 133(3), 327-333. doi: 10.1080/00207454.2021.1916489en_US
dc.identifier.doi10.1080/00207454.2021.1916489
dc.identifier.endpage333
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.issue3
dc.identifier.pmid33851572
dc.identifier.scopus2-s2.0-85105363017
dc.identifier.scopusqualityQ2
dc.identifier.startpage327
dc.identifier.urihttps://hdl.handle.net/11729/3145
dc.identifier.urihttp://dx.doi.org/10.1080/00207454.2021.1916489
dc.identifier.volume133
dc.identifier.wosWOS:000647333900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScience Citation Index Expanded (SCI-EXPANDED)en_US
dc.institutionauthorYıldırım, Elifen_US
dc.institutionauthorid0000-0003-3445-9197
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherTaylor & Francisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSepsisen_US
dc.subjectTREM2en_US
dc.subjectCognitiveen_US
dc.subjectEncephalopathyen_US
dc.subjectNeurofilament light chainen_US
dc.subjectBrain-dysfunctionen_US
dc.subjectSeptic shocken_US
dc.subjectCareen_US
dc.subjectReliabilityen_US
dc.subjectActivationen_US
dc.subjectValidityen_US
dc.subjectDeliriumen_US
dc.titleElevated sTREM2 and NFL levels in patients with sepsis associated encephalopathyen_US
dc.typeArticleen_US
dspace.entity.typePublication

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