Investigation of symptom-specific functional connectivity patterns in Parkinson’s disease

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dc.authorid0000-0001-6625-6787
dc.authorid0000-0002-6588-3479
dc.authorid0000-0002-2817-5596
dc.authorid0000-0003-1956-575X
dc.authorid0000-0002-1124-3695
dc.authorid0000-0002-1332-3007
dc.authorid0000-0001-6032-0856
dc.authorid0000-0002-4624-4428
dc.authorid0000-0002-8997-878X
dc.authorid0000-0003-2908-8475
dc.authorid0000-0002-4483-0394
dc.authorid0000-0002-6803-734X
dc.contributor.authorKıçik, Anien_US
dc.contributor.authorBayram, Alien_US
dc.contributor.authorErdoğdu, Emelen_US
dc.contributor.authorKurt, Elifen_US
dc.contributor.authorSarıdede, Dilek Betülen_US
dc.contributor.authorCengiz, Sevimen_US
dc.contributor.authorBilgiç, Başaren_US
dc.contributor.authorHanağası, Haşmeten_US
dc.contributor.authorÖztürk Işık, Esinen_US
dc.contributor.authorGürvit, Hakanen_US
dc.contributor.authorTüzün, Erdemen_US
dc.contributor.authorDemiralp, Tameren_US
dc.date.accessioned2025-09-12T07:34:13Z
dc.date.available2025-09-12T07:34:13Z
dc.date.issued2025-06-14
dc.departmentIşık Üniversitesi, İktisadi, İdari ve Sosyal Bilimler Fakültesi, Psikoloji Bölümüen_US
dc.departmentIşık University, Faculty of Economics, Administrative and Social Sciences, Department of Psychologyen_US
dc.descriptionOpen access funding provided by the Scientific and Technological Research Council of T\u00FCrkiye (T\u00DCB\u0130TAK). This study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) 1001 [Grant #115S219].en_US
dc.description.abstractParkinson’s disease (PD) is a complex neurodegenerative disease, characterized by pronounced heterogeneity in symptoms. This study investigates the functional connectivity (FC) patterns associated with distinct symptom clusters, aiming to elucidate the heterogeneity in PD and uncover the neural mechanisms underlying its motor and cognitive symptoms. Resting-state functional MRI (rs-fMRI) data from 55 non-demented PD patients and 24 healthy controls (HC) were used to perform seed-to-seed FC analyses. A clustering algorithm was applied to the cognitive and motor scores of all PD patients to generate relatively homogeneous symptomatic subgroups. PD patients exhibited a general decrease in FC within a network comprising the sensorimotor network (SMN) and the visual network (VN) regions. Symptom-based clustering revealed three relatively homogeneous subgroups, exhibiting a gradient pattern: patients with greater motor deficits showed significant disconnection within the SMN, whereas patients with greater visuospatial deficits exhibited reduced FC in an extended subnetwork, with pronounced disconnections between the VN and SMN areas. Our study demonstrated a notable disconnection between the SMN and VN, indicating impaired visual-motor integration in PD. Stronger disconnection within the SMN was associated with greater motor dysfunction, and stronger visual-sensorimotor disconnections were associated with greater visuospatial deficits. These findings suggest that at least two separate routes of functional disconnection may be responsible for the inhomogeneous symptom distribution in PD.en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumuen_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationKıçik, A., Bayram, A., Erdoğdu, E., Kurt, E., Sarıdede, D. B., Cengiz, S., Bilgiç, B., Hanağası, H., Öztürk Işık, E., Gürvit, H., Tüzün, E. & Demiralp, T. (2025). Investigation of symptom-specific functional connectivity patterns in Parkinson’s disease. Neurological Sciences, 46(9), 4385-4396. doi:https://doi.org/10.1007/s10072-025-08287-4en_US
dc.identifier.doi10.1007/s10072-025-08287-4
dc.identifier.endpage4396
dc.identifier.issn1590-1874
dc.identifier.issn1590-3478
dc.identifier.issue9
dc.identifier.pmid40514593
dc.identifier.scopus2-s2.0-105007888425
dc.identifier.scopusqualityQ1
dc.identifier.startpage4385
dc.identifier.urihttps://hdl.handle.net/11729/6696
dc.identifier.urihttps://doi.org/10.1007/s10072-025-08287-4
dc.identifier.volume46
dc.identifier.wosWOS:001507798900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScience Citation Index Expanded (SCI-EXPANDED)en_US
dc.institutionauthorErdoğdu, Emelen_US
dc.institutionauthorid0000-0002-2817-5596
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherSpringer-Verlag Italia S.R.L.en_US
dc.relation.ispartofNeurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCognitive impairmenten_US
dc.subjectFunctional connectivityen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectParkinson’s diseaseen_US
dc.subjectVisuospatial functionsen_US
dc.subjectAgeden_US
dc.subjectBrainen_US
dc.subjectBrain Mappingen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMiddle ageden_US
dc.subjectNeural pathwaysen_US
dc.subjectParkinson diseaseen_US
dc.subjectDiagnostic imagingen_US
dc.subjectNerve tracten_US
dc.subjectNuclear magnetic resonance imagingen_US
dc.subjectPathophysiologyen_US
dc.subjectMild cognitive impairmenten_US
dc.subjectResting-stateen_US
dc.subjectNetworksen_US
dc.subjectDysfunctionen_US
dc.subjectDementiaen_US
dc.subjectLevodopaen_US
dc.subjectDeclineen_US
dc.titleInvestigation of symptom-specific functional connectivity patterns in Parkinson’s diseaseen_US
dc.typeArticleen_US
dspace.entity.typePublicationen_US

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