The cerebral blood flow deficits in Parkinson’s disease with mild cognitive impairment using arterial spin labeling MRI
Yükleniyor...
Dosyalar
Tarih
2020-09
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Parkinson's disease (PD) with mild cognitive impairment (PD-MCI) is currently diagnosed based on an arbitrarily predefined standard deviation of neuropsychological test scores, and more objective biomarkers for PD-MCI diagnosis are needed. The purpose of this study was to define possible brain perfusion-based biomarkers of not only mild cognitive impairment, but also risky gene carriers in PD using arterial spin labeling magnetic resonance imaging (ASL-MRI). Fifteen healthy controls (HC), 26 cognitively normal PD (PD-CN), and 27 PD-MCI subjects participated in this study. ASL-MRI data were acquired by signal targeting with alternating radio-frequency labeling with Look-Locker sequence at 3 T. Single nucleotide polymorphism genotyping for rs9468 [microtubule-associated protein tau (MAPT) H1/H1 versus H1/H2 haplotype] was performed using a Stratagene Mx3005p real-time polymerase chain-reaction system (Agilent Technologies, USA). There were 15 subjects withMAPTH1/H1 and 11 subjects withMAPTH1/H2 within PD-MCI, and 33 subjects withMAPTH1/H1 and 19 subjects withMAPTH1/H2 within all PD. Voxel-wise differences of cerebral blood flow (CBF) values between HC, PD-CN and PD-MCI were assessed by one-way analysis of variance followed by pairwise post hoc comparisons. Further, the subgroup of PD patients carrying the riskyMAPTH1/H1 haplotype was compared with noncarriers (MAPTH1/H2 haplotype) in terms of CBF by a two-samplettest. A pattern that could be summarized as "posterior hypoperfusion" (PH) differentiated the PD-MCI group from the HC group with an accuracy of 92.6% (sensitivity = 93%, specificity = 93%). Additionally, the PD patients withMAPTH1/H1 haplotype had decreased perfusion than the ones with H1/H2 haplotype at the posterior areas of the visual network (VN), default mode network (DMN), and dorsal attention network (DAN). The PH-type pattern in ASL-MRI could be employed as a biomarker of both current cognitive impairment and future cognitive decline in PD.
Açıklama
Anahtar Kelimeler
Arterial spin labeling MRI, Cerebral blood flow, Parkinson's disease, Mild cognitive impairment, Microtubule-associated protein tau (MAPT), Functional connectivity, Cortical hypoperfusion, Diagnostic-criteria, Perfusion, Dementia, Organization, Network, Progression, Pattern, State
Kaynak
Journal of Neural Transmission
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
127
Sayı
9
Künye
Arslan, D. B., Gürvit, İ. H., Genç, O., Kıçik, A., Eryürek, K., Cengiz, S., Erdoğdu, E., Yıldırım, Z., Tüfekçioğlu, Z., Uluğ, A. M., Bilgiç, B., Hanağası, H., Tüzün, E., Demiralp, T. & Öztürk Işık, E. (2020). The cerebral blood flow deficits in Parkinson’s disease with mild cognitive impairment using arterial spin labeling MRI. Journal of Neural Transmission, 127(9),1285-1294. doi:10.1007/s00702-020-02227-6
