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Yayın The effect of the interaction between autistic traits and psychotic proneness on empathy: a cross-sectional study with a non-clinical sample(Emerald Publishing, 2023-11-08) Yıldırım, ElifPurpose: Recent evidence indicates an improving effect of the co-occurrence of autistic traits and psychotic symptoms on social cognition, but there is no agreement on the effect of the interaction between autistic traits and psychotic proneness on empathy. The aim of this study is to examine the effect of the interaction between autistic traits and positive psychotic experiences on cognitive and affective empathy. Design/methodology/approach: The sample consisted of 420 adults aged between 18 and 60. Assessments were administered anonymously online. Empathic abilities were evaluated by the Interpersonal Reactivity Index (IRI). While Autism Spectrum Quotient (AQ) was applied to measure autistic traits, The Community Assessment of Psychic Experience (CAPE) was used as a measurement of positive psychotic experiences. Findings: A series of regression analyses showed that although AQ and CAPE scores were not correlated with cognitive-IRI, the interaction between these scores predicted cognitive-IRI scores. It was found that the personal distress subscale of IRI was significantly associated with AQ, but this relationship was moderated by CAPE scores. Originality/value: These findings provide a different perspective on understanding social cognitive impairments in autism, which may have potential clinical implications. Findings also contribute to explaining the individual differences in empathic abilities.Yayın Neuropsychiatric outcomes and caregiver distress in primary progressive aphasia(Wiley, 2023-01) Seçkin, Mustafa; Yıldırım, Elif; Demir, İlayda; Orhun, Ömer; Bülbül, Ezgi; Velioğlu, H. Aziz; Öget, Öktem; Yeşilot, Nilüfer; Çoban, Oğuzhan; Gürvit, HakanBackground: In this study, we aimed to outline the neuropsychiatric consequences of primary progressive aphasia (PPA) and to understand how neuropsychiatric symptomatology affects distress in caregivers. Methods: The Neuropsychiatric Inventory (NPI) including the distress index (NPI-Distress) was used. Additional information about the caregiver burden was obtained using Zarit Burden Interview (ZBI). NPI, NPI-Distress, and ZBI data from 17 patients with a clinical diagnosis of PPA were compared with 10 stroke aphasia patients. Neuropsychiatric symptomatology was investigated based on three clusters; Mood, Frontal/Comportmental, and Psychotic/Disruptive. Additionally, the Activities of Daily Living Questionnaire (ADLQ) was used to outline the functional impairment. Twelve healthy controls were included to compare the neurocognitive test scores with PPA and stroke aphasia groups. Results: A greater number of neuropsychiatric symptoms were observed in the PPA group compared to the stroke aphasia group. The number of symptoms in Mood, and Frontal/Comportmental clusters were greater than the number of symptoms in Psychotic/Disruptive clusters in the PPA group, whereas no significant relationship between the number of symptoms and symptom clusters was found in the stroke aphasia group. In the PPA group, a strong correlation was found between the NPI-Frequency × Severity scores and the NPI-Distress scores. Moreover, the NPI-Distress scores in the PPA group strongly correlated with the ZBI scores. Scores for anxiety, irritability/lability, and apathy had a stronger correlation with the NPI-Distress scores compared to the other NPI symptoms. The Communication subscale was the most impaired domain in the PPA group. Travel, and Employment and Recreation subscales showed greater functional impairment in the stroke aphasia group compared to the PPA group. Conclusions: Neuropsychiatric symptoms in PPA in our study were more frequent than previously reported. Furthermore, the distress index of the NPI was not only correlated with the severity of the neuropsychiatric symptoms but also reflected the overall burden on the caregivers in the PPA group.Yayın Identification of metabolic correlates of mild cognitive impairment in Parkinson's disease using magnetic resonance spectroscopic imaging and machine learning(Springer Science and Business Media Deutschland GmbH, 2022-12) Cengiz, Sevim; Arslan, Dilek Betül; Kıçik, Ani; Erdoğdu, Emel; Yıldırım, Muhammed; Hatay, Gökçe Hale; Tüfekçioğlu, Zeynep; Uluğ, Aziz Müfit; Bilgiç, Başar; Hanagasi, Haşmet; Demiralp, Tamer; Gürvit, Hakan; Öztürk Işıkk, EsinObjective: To investigate metabolic changes of mild cognitive impairment in Parkinson’s disease (PD-MCI) using proton magnetic resonance spectroscopic imaging (1H-MRSI). Methods: Sixteen healthy controls (HC), 26 cognitively normal Parkinson’s disease (PD-CN) patients, and 34 PD-MCI patients were scanned in this prospective study. Neuropsychological tests were performed, and three-dimensional 1H-MRSI was obtained at 3 T. Metabolic parameters and neuropsychological test scores were compared between PD-MCI, PD-CN, and HC. The correlations between neuropsychological test scores and metabolic intensities were also assessed. Supervised machine learning algorithms were applied to classify HC, PD-CN, and PD-MCI groups based on metabolite levels. Results: PD-MCI had a lower corrected total N-acetylaspartate over total creatine ratio (tNAA/tCr) in the right precentral gyrus, corresponding to the sensorimotor network (p = 0.01), and a lower tNAA over myoinositol ratio (tNAA/mI) at a part of the default mode network, corresponding to the retrosplenial cortex (p = 0.04) than PD-CN. The HC and PD-MCI patients were classified with an accuracy of 86.4% (sensitivity = 72.7% and specificity = 81.8%) using bagged trees. Conclusion: 1H-MRSI revealed metabolic changes in the default mode, ventral attention/salience, and sensorimotor networks of PD-MCI patients, which could be summarized mainly as ‘posterior cortical metabolic changes’ related with cognitive dysfunction.Yayın Measurement of perceived psychological safety: integration, review and evidences for the scale in the context of Turkiye(İstanbul Üniversitesi Yayınevi, 2022-06-22) Bülbül, Seçil; İşiaçık, Serin; Aytaç, SerpilPsychological safety can predict many positive individual and organizational outcomes at work, and previous research addressed how psychological safety contributes to positive work attitudes and behaviors. In Turkey, there is quite an amount of research showing the contributing role of psychological safety perception on employees' positive performance behaviors and organizational effectiveness and innovativeness. However, previous research in Turkey does not adequately show the reliability and validity of the psychological safety scale, which was developed by Edmondson (1999). Based on the suggested requirement this study aimed to investigate the psychological safety perceptions of individuals who work in various sectors in Turkey. The adapted version of the psychological safety scale was used to gain evidence for the reliability and validity of the instrument in Turkey. In total, 585 individuals working in various industries and from various occupational groups participated in the research. Both exploratory factor analysis and the confirmatory factor analysis showed that Turkish adapted version of the psychological safety scale was valid and reliable.Yayın Primary versus secondary psychopathy: Coping styles as a mediator between psychopathy and well-being(Springer, 2022-09) Saltoğlu, Seren; Uysal Irak, DorukThis study investigated the differences in the levels of adaptiveness of primary and secondary psychopathy in the context of psychological well-being (depression, anxiety, stress, and life satisfaction) and the mediating role of three different coping styles (task-focused coping, emotional coping, and avoidance coping) in this relationship. In a non-clinical sample of 297 participants, results indicated that both primary and secondary psychopathy facets were likely to rely on maladaptive coping styles and have poor psychological well-being. Nevertheless, in comparison to secondary psychopathy, primary psychopathy was related to less maladaptive choice of coping styles and to comparatively higher levels of psychological well-being. These findings indicated the need for clinical prevention and intervention programs for teaching sub-clinical psychopaths – particularly people with high levels of secondary psychopathy – effective coping skills and, consequently, ameliorating their psychological well-being and diminishing their negative impact on other people, while taking psychopathy’s multidimensional nature into account.Yayın Ev kadınlarında tükenmişlik ve somatizasyon: depresyonun yordayıcıları(Cyprus Mental Health Institute, 2022-03-09) Karaköse, Selin; Ulusoy, Ayşe NehirÖncül belirtilerinden biri somatik semptomlar olan depresyonun, evli ve çalışmayan kadınlarda daha yaygın görüldüğü bilinmektedir. Ev kadınlarında depresyon araştırmacıların sıklıkla üzerinde çalıştığı bir konu olsa da, alan yazına son yıllarda kazandırılan ve depresyonun yordayıcılarından biri olan tükenmişlik kavramı, somatizasyon ile birlikte henüz ev kadınlarında araştırılmamıştır. Bu çalışmanın amacı ev kadınlarında tükenmişlik ve somatizasyonun depresyon üzerindekini rolünü araştırmaktır. Kesitsel ve ilişkisel araştırma modeli ile yürütülen bu çalışmaya Türkiye’de yaşayan, evli ve çalışmayan, 20-65 yaş arasında (Ort. =41.74, SS=11.09) 388 kadın katılmıştır. Sosyo-Demografik Bilgi ve Veri Formuna ek olarak, Ev Hanımlarında Tükenmişlik Ölçeği (EHTÖ), Kısa Semptom Envanteri-Somatizasyon alt boyutu (SCL-90-SOMA) ve Depresyon Anksiyete Stres Ölçeği (DASS-21)- Depresyon alt boyutunu içeren anket bataryası katılımcılara çevrimiçi olaraksunulmuştur. Hiyerarşik çoklu regresyon analizi sonuçlarına göre, yaş, çocuk sayısı ve psikiyatrik tanı kontrol edildiğinde,tükenmişlik ve somatizasyon depresyonu pozitif yönde yordamaktadır. Elde edilen bu bulgular dahilinde, ev kadınlarında tükenmişliğe yönelik müdahale çalışmaları yapılmasının ve somatik belirtilerin depresyonun öncül sinyalleri olarak değerlendirilmesinin depresyonun klinik tablosu ile mücadelede yol göstereceği olacağı düşünülmektedir.Yayın Assessing the mediating relationships between psychological factors in children with attention deficit hyperactivity disorder and cognitive disengagement syndrome(Routledge Journals, Taylor & Francis Ltd, 2024-04) İnci İzmir, Sevim Berrin; Aktan, Zekeriya Deniz; Ercan, Eyüp SabriThis study aims to investigate the predictive and mediating relationships between emotion dysregulation, internalizing disorders, family functionality, loneliness preference, and executive functions (EF) in children with attention deficit hyperactivity disorder and cognitive disengagement syndrome (ADHD + CDS). This study included 176 children and adolescents (92 boys, 84 girls) who were diagnosed with ADHD + CDS according to the Diagnostic and Statistical Manual of Mental Disorders, the Fifth Edition criteria by a fellowship-trained child and adolescent psychiatrist, between ages 8 -12 (M = 10, SD = 1.52) with a convenience sampling method. The solitude scale for children, difficulties in emotion dysregulation scale, Child Behavior Checklist, Barkley Sluggish Cognitive Tempo Scale, Family assessment device, and CNS Vital Signs test were used. The results showed that difficulty in emotion regulation, preference for loneliness, internalizing disorders and CDS symptom severity did not have a mediating effect between family functionality and EF. Still, emotion dysregulation mediates the relationship between EF and internalizing disorders by itself and through loneliness preference. Also, preference for loneliness and emotion dysregulation had a mediating effect between family functionality and internalizing disorders. Finally, it was found that the effect of emotion regulation difficulty, loneliness preference, and internalizing disorders had a mediating role between CDS symptom severity and family functionality. In conclusion, the information obtained from this study on the etiology of CDS may guide future studies.Yayın The effect of SARS-CoV-2 virus on resting-state functional connectivity during adolescence: Investigating brain correlates of psychotic-like experiences and SARS-CoV-2 related inflammation response(Elsevier Ireland Ltd, 2023-12) Yılmaz Kafalı, Helin; Daşgın, Hacer; Şahin Çevik, Didenur; Sozan, Sara Sinem; Oğuz, Kader K.; Mutlu, Müge; Özkaya Parlakay, Aslınur; Toulopoulou, TimotheaWe first aimed to investigate resting-state functional connectivity (rs-FC) differences between adolescents exposed to SARS-CoV-2 and healthy controls. Secondly, the moderator effect of PLEs on group differences in rs-FC was examined. Thirdly, brain correlates of inflammation response during acute SARS-CoV-2 infection were investigated. Eighty-two participants aged between 14 and 24 years (SARS-CoV-2 (n = 35), controls (n = 47)) were examined using rs-fMRI. Seed-based rs-FC analysis was performed. The positive subscale of Community Assessment of Psychotic Experiences-42 (CAPE-Pos) was used to measure PLEs. The SARS-CoV-2 group had a lesser rs-FC within sensorimotor network (SMN), central executive network (CEN) and language network (LN), but an increased rs-FC within visual network (VN) compared to controls. No significant differences were detected between the groups regarding CAPE-Pos-score. However, including CAPE-Pos as a covariate, we found increased rs-FC within CEN and SN in SARS-CoV-2 compared to controls. Among the SARS-CoV-2 group, neutrophil/lymphocyte and thrombocyte*neutrophil/lymphocyte ratio was correlated with decreased/increased FC within DMN and SN, and increased FC within CEN. Our results showed rs-FC alterations within the SMN, CEN, LN, and VN among adolescents exposed to SARS-CoV-2. Moreover, changes in rs-FC associated with PLEs existed in these adolescents despite the absence of clinical changes. Furthermore, inflammation response was correlated with alterations in FC within the triple network system.Yayın The relationship between marital satisfaction and depression: The mediation effect of housewife burn(Wiley, 2023-12) Ulusoy, Ayşe Nehir; Karaköse, Selin[No abstract available]Yayın Attitudes of psychiatrists towards people with mental illness: a cross-sectional, multicentre study of stigma in 32 European countries(Elsevier Ltd, 2023-12) Őri, Dorottya; Szocsics, Péter; Molnár, Tamás; Bankovska Motlova, Lucie; Kazakova, Olga; Mörkl, Sabrina; Wallies, Michael; Abdulhakim, Mohamed; Boivin, Sylvie; Bruna, Krista; Cabaços, Carolina; Carbone, Elvira Anna; Dashi, Elona; Grech, Giovanni; Greguras, Stjepan; Ivanovic, Iva; Guevara, Kaloyan; Kakar, Selay; Kotsis, Konstantinos; Ingeholm Klinkby, Ida Maria; Maslak, Jovana; Matheiken, Shevonne; Mirkovic, Ana; Nechepurenko, Nikita; Panayi, Angelis; Pereira, Ana Telma Fernandes; Pomarol-Clotet, Edith; Raaj, Shaeraine; Prelog, Polona Rus; Soler-Vidal, Joan; Strumila, Robertas; Schuster, Florian; Kisand, Helena; Reim, Ann; Ahmadova, Gumru; Vircik, Matus; Yılmaz Kafalı, Helin; Grinko, Natalia; Győrffy, Zsuzsa; Rózsa,SándorBackground Mental health-related stigma occurs among the public and professionals alike. The lived experience of mental illness has been linked to less stigmatising attitudes. However, data on psychiatrists and the relationship between stigmatising attitudes and psychotherapeutic activity or case discussion groups remains scarce.Methods A cross-sectional multicentre study was performed in 32 European countries to investigate the lived experiences and attitudes of psychiatrists toward patients with mental illness as well as the relationship between stigma, psychosocial and professional factors. The self-reported, anonymous, internet-based Opening Minds Stigma Scale for Health Care Providers was used to measure the stigmatising attitudes. The survey was translated into the local language of each participating country. All participants were practising specialists and trainees in general adult or child and adolescent psychiatry. The study took place between 2nd October, 2019 and 9th July, 2021 and was preregistered at ClinicalTrial.gov (NCT04644978).Findings A total of 4245 psychiatrists completed the survey. The majority, 2797 (66%), had completed training in psychiatry, and 3320 (78%) worked in adult psychiatry. The final regression model showed that across European countries more favourable attitudes toward people with mental illness were statistically significantly associated with the lived experience of participants (including seeking help for their own mental health conditions (d = -0.92, 95% confidence interval (CI) = -1.68 to -0.15, p = 0.019), receiving medical treatment for a mental illness (d = -0.88, 95% CI = -1.71 to -0.04, p = 0.040), as well as having a friend or a family member similarly affected (d = -0.68, 95% CI = -1.14 to -0.22, p = 0.004)), being surrounded by colleagues who are less stigmatising (d = -0.98, 95% CI = -1.26 to -0.70, p < 0.001), providing psychotherapy to patients (d = -1.14, 95% CI = -1.63 to -0.65 p < 0.001), and being open to (d = -1.69, 95% CI = -2.53 to -0.85, p < 0.001) and actively participating in (d = -0.94, 95% CI = -1.45 to -0.42, p < 0.001) case discussion, supervision, or Balint groups.Interpretation Our study highlights the importance of psychotherapy training, supervision, case discussions and Balint groups in reducing the stigmatising attitudes of psychiatrists toward patients. As the findings represent cross -national predictors, Europe-wide policy interventions, national psychiatric education systems and the management of psychiatric institutions should take these findings into consideration.Funding National Youth Talent Award (Ministry of Human Resources, Hungary, (NTP-NFTo-20-B-0134). All authors received no funding for their contribution.
