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Yayın The comparison of functional connectivity in Parkinson’s Disease patients with and without Parkin gene mutations(Turkish Neuropsychiatric Society, 2025-06-19) Çebi, Merve; Ay, Ulaş; Kıçik, Ani; Erdoğdu, Emel; Tepgeç, Fatih; Uyguner, Zehra Oya; Tüfekçioğlu, Zeynep; Samancı, Bedia; Bilgiç, Başar; Emre, Murat; Demiralp, Tamer; Hanağası, Haşmet AyhanIntroduction: Mapping the functional connectivity of brain regions became appealing in recent research in neurology. Accordingly, a growing body of evidence shows resting-state functional connectivity (rsFC) changes in neurodegenerative disorders including Parkinson’s Disease (PD). As characterised by extensive and progressive dopaminergic loss in the substantia nigra, PD emerges with serious motor and non-motor dysfunctions. In the literature, the minority of PD cases have been associated with certain genetic mutations. The aim of this study was to investigate the rsFC in a group of PD patients having Parkin gene mutation. Method: Twelve PD patients with Parkin mutation (PP-PD), 12 PD patients without Parkin mutation (PN-PD) and 12 healthy controls (HC) were included in the study. All participants underwent a resting-state functional magnetic resonance imaging as well as a neuropsychological assessment and clinical examination. Results: Results indicated that PP-PD had longer disease duration, a higher rate of dyskinesia and lower scores on complex visual perception tests. The resting state networks showed that all PD (consisting of PP-PD and PN-PD) and PP-PD groups had increased functional connectivity in the frontoparietal network as compared to the HC. In addition, the PP-PD group displayed decreased functional connectivity in the dorsal attention network compared to the PN-PD. Conclusion: In conclusion, our data suggests that PD with Parkin gene mutation might be emerging with distinct resting state functional connectivity changes in the brain.Yayın Decision making, emotion recognition and childhood traumatic experiences in murder convicts ımprisoned with aggravated life sentence: a prison study(Turkish Neuropsychiatric Society, 2025-03) Çıkrıkçılı, Uğur; Yıldırım, Elif; Buker, Seda; Ger, Can; Erözden, Ozan; Gürvit, Hakan; Saydam, BilginIntroduction: Decision-making and emotion recognition are two fundamental themes in social cognition. Disorders in these areas can lead to interpersonal, psychosocial, and legal problems for the individual and society. The likelihood of consequent aggression and crime makes them foci of forensic psychiatry over time. In this study, two developmental disorders that have a clear relationship with crime, that are antisocial personality disorder (ASPD), and psychopathy are investigated for their relationship with these social cognitive deficits.Methods: The present study involved 23 male prison inmates who were diagnosed with both antisocial personality disorder and psychopathy, as well as 23 control participants who were matched for age, gender, and level of education. Following the psychiatric interview, Reading the Mind in the Eyes Test (RMET), the Iowa Gambling Test (IGT), Toronto Alexithymia Scale (TAS), Defense Styles Questionnaire (DSQ), Childhood Psychic Trauma Scale (CTQ), Hare Psychopathy Checklist (PCL-R) were administered to all participants. Results: The results of the study showed that ASPD group performed statistically worse than healthy controls in TAS, CTQ, all items of DSQ, PCL-R Factor 1 and 2, and all the IGT scores (p<0.05). There were no statistically significant difference between in the RMET test performancesConclusion: These results suggest that ASPD and psychopathy lead to impaired decision-making behaviors due to the inability to recognize one’s own emotions and impulsivity, and that these characteristics play a critical role in the criminal behavior of individuals. In addition, contrary to expectations, the results of affective theory of mind assessed with the RMET showed similar characteristics in homicide convicts and healthy controls. These data indicate the need for further research in the field of forensic psychiatry.Yayın Efficacy, all-cause discontinuation, and safety of serotonergic psychedelics and MDMA to treat mental disorders: a living systematic review with meta-analysis(Elsevier B.V., 2025-12) Højlund, Mikkel; Yılmaz Kafalı, Helin; Kırmızı, Begüm; Fusar-Poli, Paolo; Correll, Christoph U.; Cortese, Samuele; Sabé, Michel; Fiedorowicz, Jess; Saraf, Gayatri; Zein, Josephine; Berk, Michael; Husain, Muhammad I.; Rosenblat, Joshua D.; Rubaiyat, Ruby; Corace, Kim; Wong, Stanley; Hatcher, Simon; Kaluzienski, Mark; Yatham, Lakshmi N.; Cipriani, Andrea; Gosling, Corentin J.; Carhart-Harris, Robin; Tanuseputro, Peter; Myran, Daniel T.; Fabiano, Nicholas; Moher, David; Mayo, Leah M.; Nicholls, Stuart G.; White, Tracy; Prisco, Michele De; Radua, Joaquim; Vieta, Eduard; Ladha, Karim S.; Katz, Jay; Veroniki, Areti A.; Solmi, MarcoSerotonergic psychedelics and 3,4-methylendioxtmethamphetamine (MDMA) are promising treatments for mental disorders with a continuously evolving evidence base. We searched Pubmed/Scopus/clinical trial registries up to 08july2025 for double-blind randomized controlled trials (RCTs) testing MDMA or serotonergic psychedelics in patients with mental disorders. Primary outcomes were change in disease-specific symptoms and all-cause discontinuation. Standardized mean differences (SMD) and relative risk (RR) were estimated using random-effects meta-analysis. Risk of bias (RoB) was assessed with Cochrane’s RoB-tool version 2 and certainty of evidence with GRADE. The review is maintained as living systematic review ( https://ebipsyche-database.org/ ). We included 30 RCTs (1480 participants; female=45.8 %; with psychological support=83.3 %; high RoB=83.3 %). In post-traumatic stress disorder (PTSD), MDMA reduced PTSD symptoms compared to any control ( k = 11; SMD=-0.85 [-1.09; -0.60]; I2=0 %; GRADE=low). In major depressive disorder (MDD), psilocybin/ayahuasca/LSD reduced depressive symptoms ( k = 8; SMD=-0.62 [-0.97; -0.28]; I2=55 %; GRADE=very low). In anxiety disorders, both MDMA and serotonergic psychedelics reduced anxiety symptoms (SMDMDMA=-1.18 [-2.04; -0.32]; I2=0 %; k = 2; GRADE=low and SMDserotonergic=-0.88 [-1.70; -0.06]; I2=54 %; k = 5; GRADE=very low). In alcohol use disorder, neither psilocybin nor LSD reduced abstinence rates ( k = 6; RR=1.42 [0.89; 2.26]; I2=7 %; GRADE=very low). In attention-deficit hyperactivity disorder (ADHD), LSD did not reduce ADHD symptoms ( k = 1; SMD=0.22 [-0.32; 0.76]; GRADE=very low). Moderate certainty in evidence was only found for MDMA on PTSD symptoms when compared to placebo. MDMA/serotonergic psychedelics were not associated with higher risk of all-cause discontinuation (RRMDMA=0.74 [0.32; 1.72]; RRserotonergic=0.81 [0.56; 1.15]). Overall, MDMA/serotonergic psychedelics are promising for the treatment of PTSD, MDD, and anxiety disorders with moderate to large effect sizes. Pragmatic trials, long-term, head-to-head trials exploring the role of psychological support, aiming to identify predictors of response, and accounting for expectancy and functional unblinding are needed. Studies addressing these limitations will likely be required for regulatory approval of psychedelic drugs.Yayın Ebeveyn tutumları ve çocuk davranış problemleri arasındaki ilişkide ebeveyn mükemmeliyetçiliğinin aracı rolü(Galenos Publishing House, 2025-11-11) İnce, Merve; Akçınar, Berna; Yılmaz, SimayAmaç: Bu çalışma, annelerin mükemmeliyetçiliğinin, annelerin ebeveynlik stilleri ile çocukların içselleştirme ve dışsallaştırma davranış problemleri arasındaki ilişkide aracılık rolünü incelemeyi amaçlamaktadır. Gereç ve Yöntem: Örneklem, 3-6 yaş arası çocukları olan 271 anneden oluşmaktadır. Katılımcılardan sosyodemografik bilgi formu, Ebeveyn Tutum Ölçeği, Hacettepe Ruhsal Uyum Ölçeği ve Çok Boyutlu Mükemmeliyetçilik Ölçeğini doldurmaları istenmiş ve veriler çevrimiçi olarak toplanmıştır. Bulgular: Çalışmanın ana hipotezini test etmek için yapılan analiz bulgularına göre demokratik ebeveynlik, içselleştirme (b=-0,117, p<0,05) ve dışsallaştırma (b=-0,076, p<0,05) davranış problemlerini negatif yönde yordamıştır. Bu ilişkilerde annenin kendine yönelik mükemmeliyetçiliği (KYM) ve sosyal olarak belirlenen mükemmeliyetçilik (SBM) aracılık etmemiştir. Otoriter ebeveynlik, içselleştirme (b=0,046, p<0,05) ve dışsallaştırma (b=0,049, p<0,05) davranış problemleriyle pozitif yönde ilişkilendirilmiş ve bu problemler üzerindeki etkilerinde KYM ve SBM aracılık rolü üstlenmemiştir. Buna karşın, aşırı korumacı ve izin verici tutumlar bu davranış problemlerini anlamlı bir şekilde yordamamıştır. Ayrıca, annelerin KYM’nin, aşırı korumacı ve izin verici ebeveynlik tutumları ile içselleştirme ve dışsallaştırma davranış problemleri arasındaki ilişkide aracılık etkisi olmadığı bulunmuş; ancak SBM’nin aşırı koruyucu ebeveyn tutumu ile içselleştirme [b=0,017, standart hata (SH)=0,009, güven aralığı (GA): (0,003, 0,038)] ve dışsallaştırma [b=0,012, SH=0,007, GA: (0,001, 0,029)] davranış problemlerinde ve izin verici ebeveyn tutumu ile içselleştirme davranış problemi [b=0,013, SH=0,008, GA: (0,000, 0,033)] arasında aracılık etkisinde bulunduğu görülmüştür. Sonuç: Bu çalışma, ebeveynlik tutumları ve özelliklerinin çocukların ruh sağlığı üzerindeki önemli rolünü vurgulamakta, ebeveynlerin etkili ve olumlu ebeveynlik yaklaşımlarını benimsemeleri için pratik müdahalelerin gerekliliğini belirtmektedir.
