White-matter changes in early and late stages of mild cognitive impairment
Yükleniyor...
Dosyalar
Tarih
2020-08
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Churchill Livingstone
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Mild Cognitive Impairment (MCI) is characterized by cognitive deficits that exceed age-related decline, but not interfering with daily living activities. Amnestic type of the disorder (aMCI) is known to have a high risk to progress to Alzheimer's Disease (AD), the most common type of dementia. Identification of very early structural changes in the brain related to the cognitive decline in MCI patients would further contribute to the understanding of the dementias. In the current study, we target to investigate whether the white-matter changes are related to structural changes, as well as the cognitive performance of MCI patients. Forty-nine MCI patients were classified as Early MCI (E-MCI, n = 24) and Late MCI (L-MCI, n = 25) due to their performance on The Free and Cued Selective Reminding Test (FCSRT). Age-Related White-Matter Changes (ARWMC) scale was used to evaluate the white-matter changes in the brain. Volumes of specific brain regions were calculated with the FreeSurfer program. Both group and correlation analyses were conducted to show if there was any association between white-matter hyperintensities (WMHs) and structural changes and cognitive performance. Our results indicate that, L-MCI patients had significantly more WMHs not in all but only in the frontal regions compared to E-MCI patients. Besides, ARWMC scores were not correlated with total hippocampal and white-matter volumes. It can be concluded that WMHs play an important role in MCI and cognitive functions are affected by white-matter changes of MCI patients, especially in the frontal regions.
Açıklama
Anahtar Kelimeler
Dementia, Episodic memory, Hippocampus, Mild cognitive impairment, White-matter hyperintensities, Alzheimers-disease, Lesions, Hyperintensities, Dysfunction, Prediction, Conversion
Kaynak
Journal of Clinical Neuroscience
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
78
Sayı
Künye
Yıldırım, E., Soncu Büyükişcan, E., Kurt, E., Bilgiç, B., Bayram, A., Ulaşoğlu Yıldız, Ç. & Femir Gurtuna, B. (2020). White-matter changes in early and late stages of mild cognitive impairment. Journal of Clinical Neuroscience, 78, 181-184. doi:10.1016/j.jocn.2020.04.078
