White-matter changes in early and late stages of mild cognitive impairment

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dc.authorid0000-0003-3649-6063
dc.authorid0000-0003-1956-575X
dc.authorid0000-0003-1849-0055
dc.authorid0000-0002-6588-3479
dc.authorid0000-0003-3445-9197
dc.authorid0000-0003-1305-0560
dc.authorid0000-0001-6032-0856
dc.contributor.authorFemir Gürtuna, Banuen_US
dc.contributor.authorKurt, Elifen_US
dc.contributor.authorUlaşoğlu Yıldız, Çiğdemen_US
dc.contributor.authorBayram, Alien_US
dc.contributor.authorYıldırım, Elifen_US
dc.contributor.authorSoncu Büyükişcan, Ezgien_US
dc.contributor.authorBilgiç, Başaren_US
dc.date.accessioned2020-04-27T09:50:35Z
dc.date.available2020-04-27T09:50:35Z
dc.date.issued2020-08
dc.departmentIşık Üniversitesi, Fen Edebiyat Fakültesi, Psikoloji Bölümüen_US
dc.departmentIşık University, Faculty of Arts and Sciences, Department of Psychologyen_US
dc.description.abstractMild Cognitive Impairment (MCI) is characterized by cognitive deficits that exceed age-related decline, but not interfering with daily living activities. Amnestic type of the disorder (aMCI) is known to have a high risk to progress to Alzheimer's Disease (AD), the most common type of dementia. Identification of very early structural changes in the brain related to the cognitive decline in MCI patients would further contribute to the understanding of the dementias. In the current study, we target to investigate whether the white-matter changes are related to structural changes, as well as the cognitive performance of MCI patients. Forty-nine MCI patients were classified as Early MCI (E-MCI, n = 24) and Late MCI (L-MCI, n = 25) due to their performance on The Free and Cued Selective Reminding Test (FCSRT). Age-Related White-Matter Changes (ARWMC) scale was used to evaluate the white-matter changes in the brain. Volumes of specific brain regions were calculated with the FreeSurfer program. Both group and correlation analyses were conducted to show if there was any association between white-matter hyperintensities (WMHs) and structural changes and cognitive performance. Our results indicate that, L-MCI patients had significantly more WMHs not in all but only in the frontal regions compared to E-MCI patients. Besides, ARWMC scores were not correlated with total hippocampal and white-matter volumes. It can be concluded that WMHs play an important role in MCI and cognitive functions are affected by white-matter changes of MCI patients, especially in the frontal regions.en_US
dc.description.sponsorshipThis work was supported by funds from TUBITAK ARDEB 1003 Program (Grant #: 114E053), Istanbul University Scientific Research Funds (Grant #s: 53037, 1567/42362) and Bogazici University Scientific Research Funds (Grant #: 10520)en_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationYıldırım, E., Soncu Büyükişcan, E., Kurt, E., Bilgiç, B., Bayram, A., Ulaşoğlu Yıldız, Ç. & Femir Gurtuna, B. (2020). White-matter changes in early and late stages of mild cognitive impairment. Journal of Clinical Neuroscience, 78, 181-184. doi:10.1016/j.jocn.2020.04.078en_US
dc.identifier.doi10.1016/j.jocn.2020.04.078
dc.identifier.endpage184
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.pmid32334962
dc.identifier.scopus2-s2.0-85083527579
dc.identifier.scopusqualityQ2
dc.identifier.startpage181
dc.identifier.urihttps://hdl.handle.net/11729/2309
dc.identifier.urihttp://dx.doi.org/10.1016/j.jocn.2020.04.078
dc.identifier.volume78
dc.identifier.wosWOS:000556833000029
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScience Citation Index Expanded (SCI-EXPANDED)en_US
dc.institutionauthorYıldırım, Elifen_US
dc.institutionauthorid0000-0003-3445-9197
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofJournal of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDementiaen_US
dc.subjectEpisodic memoryen_US
dc.subjectHippocampusen_US
dc.subjectMild cognitive impairmenten_US
dc.subjectWhite-matter hyperintensitiesen_US
dc.subjectAlzheimers-diseaseen_US
dc.subjectLesionsen_US
dc.subjectHyperintensitiesen_US
dc.subjectDysfunctionen_US
dc.subjectPredictionen_US
dc.subjectConversionen_US
dc.titleWhite-matter changes in early and late stages of mild cognitive impairmenten_US
dc.typeArticleen_US
dspace.entity.typePublication

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