Decision-making and impulse-control disorders in parkinson’s disease: Influence of dopaminergic treatment

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dc.authorid0000-0003-3445-9197
dc.authorid0000-0002-1126-0532
dc.authorid0000-0002-0194-7779
dc.contributor.authorYıldırım, Elifen_US
dc.contributor.authorAltınayar, Sibelen_US
dc.contributor.authorÇakmur, Raifen_US
dc.date.accessioned2020-05-27T06:23:58Z
dc.date.available2020-05-27T06:23:58Z
dc.date.issued2020-05-08
dc.departmentIşık Üniversitesi, Fen Edebiyat Fakültesi, Psikoloji Bölümüen_US
dc.departmentIşık University, Faculty of Arts and Sciences, Department of Psychologyen_US
dc.description.abstractObjective: Dopaminergic treatment is proved to ameliorate motor deficits in Parkinson’s disease (PD); however, it could have negative effects on behavior and cognition, including impulse controlling and decision-making. We aimed (1) to investigate the decision-making and impulse-control disorders (ICDs) of PD patients and their correlations with sociodemographical and clinical variables, dopaminergic treatment in particular, and (2) to determine the relation of decision-making with ICDs. Methods: The sample of 39 patients with PD and 37 healthy controls underwent cognitive tests and the task which analyzed decision-making (Iowa Gambling Task [IGT]). Besides assessing motor and nonmotor symptoms of patients with PD, ICDs were also scanned using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease. Results: Although patients with PD performed similarly to healthy controls on IGT, decision-making profile in PD related to clinical variables: dopaminergic treatment and duration of illness. In addition to this younger age of onset, higher dose of dopamine agonists, longer duration of illness, and impaired decision-making were together accounted for a substantial amount of variance in impulsive behaviors. Conclusions: Dopaminergic medication likely contributes to the impairment in decision-making, which may be the underlying mechanism of ICDs. Further studies will be necessary to understand the potential implications of this finding.en_US
dc.description.versionPublisher's Versionen_US
dc.identifier.citationYıldırım, E., Altınayar, S. & Çakmur, R. (2020). Decision-making and impulse-control disorders in parkinson’s disease: Influence of dopaminergic treatment. Neurological Sciences and Neurophysiology, 37(1), 11-17. doi:10.4103/NSN.NSN_12_20en_US
dc.identifier.doi10.4103/NSN.NSN_12_20
dc.identifier.endpage17
dc.identifier.issn2636-865X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85084739668
dc.identifier.scopusqualityQ4
dc.identifier.startpage11
dc.identifier.urihttps://hdl.handle.net/11729/2337
dc.identifier.urihttp://dx.doi.org/10.4103/NSN.NSN_12_20
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/424243
dc.identifier.volume37
dc.identifier.wosWOS:000538041000003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakScience Citation Index Expanded (SCI-EXPANDED)en_US
dc.institutionauthorYıldırım, Elifen_US
dc.institutionauthorid0000-0003-3445-9197
dc.language.isoenen_US
dc.peerreviewedYesen_US
dc.publicationstatusPublisheden_US
dc.publisherAVESen_US
dc.relation.ispartofNeurological Sciences and Neurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDecision-makingen_US
dc.subjectDopamineen_US
dc.subjectImpulse-control disordersen_US
dc.subjectParkinson’s diseaseen_US
dc.subjectIowa gambling tasken_US
dc.subjectAgonistsen_US
dc.subjectRewarden_US
dc.subjectRisken_US
dc.subjectMedicationen_US
dc.subjectStimulationen_US
dc.subjectBrainen_US
dc.titleDecision-making and impulse-control disorders in parkinson’s disease: Influence of dopaminergic treatmenten_US
dc.typeArticleen_US
dspace.entity.typePublication

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